scholarly journals The Dual Specificity Phosphatase Cdc25C is a Direct Target for Transcriptional Repression by the Tumor Suppressor p53

Cell Cycle ◽  
2006 ◽  
Vol 5 (7) ◽  
pp. 709-713 ◽  
Author(s):  
Selvon St. Clair ◽  
James J. Manfredi
Keyword(s):  
Tumor Suppressor ◽  
Transcriptional Repression ◽  
Tumor Suppressor P53 ◽  
Dual Specificity Phosphatase ◽  
Dual Specificity ◽  
Direct Target

scholarly journals BNIP3 Is an RB/E2F Target Gene Required for Hypoxia-Induced Autophagy

2007 ◽  
Vol 27 (17) ◽  
pp. 6229-6242 ◽  
Author(s):  
Kristin Tracy ◽  
Benjamin C. Dibling ◽  
Benjamin T. Spike ◽  
James R. Knabb ◽  
Paul Schumacker ◽  
...  
Keyword(s):  
Cell Death ◽  
Tumor Suppressor ◽  
Transcriptional Repression ◽  
Fetal Liver ◽  
Hypoxia Inducible Factor ◽  
Nutrient Deprivation ◽  
Primary Mouse ◽  
Direct Target ◽  
Nonapoptotic Cell Death

ABSTRACT Hypoxia and nutrient deprivation are environmental stresses governing the survival and adaptation of tumor cells in vivo. We have identified a novel role for the Rb tumor suppressor in protecting against nonapoptotic cell death in the developing mouse fetal liver, in primary mouse embryonic fibroblasts, and in tumor cell lines. Loss of pRb resulted in derepression of BNip3, a hypoxia-inducible member of the Bcl-2 superfamily of cell death regulators. We identified BNIP3 as a direct target of pRB/E2F-mediated transcriptional repression and showed that pRB attenuates the induction of BNIP3 by hypoxia-inducible factor to prevent autophagic cell death. BNIP3 was essential for hypoxia-induced autophagy, and its ability to promote autophagosome formation was enhanced under conditions of nutrient deprivation. Knockdown of BNIP3 reduced cell death, and remaining deaths were necrotic in nature. These studies identify BNIP3 as a key regulator of hypoxia-induced autophagy and suggest a novel role for the RB tumor suppressor in preventing nonapoptotic cell death by limiting the extent of BNIP3 induction in cells.

scholarly journals Transcriptional repression of cancer stem cell marker CD133 by tumor suppressor p53

2015 ◽  
Vol 6 (11) ◽  
pp. e1964-e1964 ◽  
Author(s):  
E K Park ◽  
J C Lee ◽  
J W Park ◽  
S Y Bang ◽  
S A Yi ◽  
...  
Keyword(s):  
Stem Cell ◽  
Tumor Suppressor ◽  
Cancer Stem Cell ◽  
Transcriptional Repression ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker ◽  
Tumor Suppressor P53

scholarly journals P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

1997 ◽  
Vol 94 (17) ◽  
pp. 9052-9057 ◽  
Author(s):  
M. P. Myers ◽  
J. P. Stolarov ◽  
C. Eng ◽  
J. Li ◽  
S. I. Wang ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Human Chromosome ◽  
Dual Specificity Phosphatase ◽  
Dual Specificity

scholarly journals Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma

Oncogene ◽  
2010 ◽  
Vol 29 (35) ◽  
pp. 4938-4946 ◽  
Author(s):  
X Shang ◽  
S A Vasudevan ◽  
Y Yu ◽  
N Ge ◽  
A D Ludwig ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Human Neuroblastoma ◽  
P53 Tumor Suppressor ◽  
Dual Specificity Phosphatase ◽  
Dual Specificity

scholarly journals The uric acid transporter SLC2A9 is a direct target gene of the tumor suppressor p53 contributing to antioxidant defense

Oncogene ◽  
2014 ◽  
Vol 34 (14) ◽  
pp. 1799-1810 ◽  
Author(s):  
Y Itahana ◽  
R Han ◽  
S Barbier ◽  
Z Lei ◽  
S Rozen ◽  
...  
Keyword(s):  
Uric Acid ◽  
Tumor Suppressor ◽  
Target Gene ◽  
Antioxidant Defense ◽  
Tumor Suppressor P53 ◽  
Direct Target Gene ◽  
Direct Target ◽  
Acid Transporter
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