scholarly journals The uric acid transporter SLC2A9 is a direct target gene of the tumor suppressor p53 contributing to antioxidant defense

Oncogene ◽  
2014 ◽  
Vol 34 (14) ◽  
pp. 1799-1810 ◽  
Author(s):  
Y Itahana ◽  
R Han ◽  
S Barbier ◽  
Z Lei ◽  
S Rozen ◽  
...  
Keyword(s):  
Uric Acid ◽  
Tumor Suppressor ◽  
Target Gene ◽  
Antioxidant Defense ◽  
Tumor Suppressor P53 ◽  
Direct Target Gene ◽  
Direct Target ◽  
Acid Transporter

scholarly journals Identification ofTDRD1as a direct target gene ofERGin primary prostate cancer

2013 ◽  
Vol 133 (2) ◽  
pp. 335-345 ◽  
Author(s):  
Joost L. Boormans ◽  
Hanneke Korsten ◽  
Angelique J.C. Ziel-van der Made ◽  
Geert J.L.H. van Leenders ◽  
Carola V. de Vos ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Target Gene ◽  
Primary Prostate Cancer ◽  
Direct Target Gene ◽  
Direct Target

p22/PACAP Response Gene 1 (PRG1): A Putative Target Gene for the Tumor Suppressor p53

1998 ◽  
Vol 865 (1 VIP, PACAP, A) ◽  
pp. 27-36 ◽  
Author(s):  
HEINER SCHAFER ◽  
ANNA TRAUZOLD ◽  
THORSTEN SEBENS ◽  
WOLFGANG DEPPERT ◽  
ULRICH R. FOLSCH ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Target Gene ◽  
Tumor Suppressor P53 ◽  
Putative Target Gene ◽  
Response Gene ◽  
Putative Target

ZNF16 (HZF1) promotes erythropoiesis and megakaryocytopoiesis via regulation of the c-KIT gene

2014 ◽  
Vol 458 (1) ◽  
pp. 171-183 ◽  
Author(s):  
Jing Chen ◽  
Xiao-Bo Li ◽  
Rui Su ◽  
Li Song ◽  
Fang Wang ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Target Gene ◽  
Megakaryocytic Differentiation ◽  
Kit Gene ◽  
Direct Target Gene ◽  
Direct Target

The present study demonstrated that ZNF16 (HZF1) plays an important role in erythroid and megakaryocytic differentiation of human haematopoietic stem/progenitor cells, identified and validated c-KIT as a direct target gene of ZNF16, and demonstrated that ZNF16 functions via its regulation on the c-Kit/c-Raf/MEK/ERK/c-Jun/HEY1/GATA1 cascade.

scholarly journals The Receptor Tyrosine Kinase EphA2 Is a Direct Target Gene of Hypermethylated in Cancer 1 (HIC1)

2011 ◽  
Vol 287 (8) ◽  
pp. 5366-5378 ◽  
Author(s):  
Bénédicte Foveau ◽  
Gaylor Boulay ◽  
Sébastien Pinte ◽  
Capucine Van Rechem ◽  
Brian R. Rood ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Receptor Tyrosine Kinase ◽  
Target Gene ◽  
Direct Target Gene ◽  
Direct Target

scholarly journals Overexpression of Uric Acid Transporter SLC2A9 Inhibits Proliferation of Hepatocellular Carcinoma Cells

2019 ◽  
Vol 27 (5) ◽  
pp. 533-540 ◽  
Author(s):  
Xiaoying Han ◽  
Jing Yang ◽  
Dong Li ◽  
Zewei Guo
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Proliferation ◽  
Uric Acid ◽  
Tumor Suppressor ◽  
Cell Apoptosis ◽  
Suppressor Gene ◽  
Potential Contribution ◽  
Acid Transporter ◽  
Underlying Mechanisms ◽  
Hcc Cells

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated mortality worldwide. Although the mechanisms of HCC progression are not well understood, recent studies demonstrated the potential contribution of uric acid transporter SLC2A9 to tumor suppression. However, the roles and underlying mechanisms are still unknown. We aimed to study the roles and mechanisms of SLC2A9 in HCC. The present study showed that SLC2A9 expression was decreased in human HCC tissues and cell lines. In addition, overexpression of SLC2A9 inhibited HCC cell proliferation. SCL2A9 induced HCC cell apoptosis by inhibiting the expression of caspase 3. Our study also revealed that upregulation of SLC2A9 reduced intracellular reactive oxygen species (ROS) accumulation. Furthermore, SLC2A9 increased the mRNA and protein expression of tumor suppressor p53 in HCC cells. Probenecid inhibits SLC2A9-mediated uric acid transport, which promotes cell proliferation, inhibits cell apoptosis, induces intracellular ROS, and decreases the expression of p53 in HCC cells. Therefore, the present study demonstrated that SLC2A9 may be a novel tumor suppressor gene and a potential therapeutic target in HCC.

scholarly journals Scavenger Chemokine (CXC Motif) Receptor 7 (CXCR7) Is a Direct Target Gene ofHIC1(Hypermethylated in Cancer 1)

2009 ◽  
Vol 284 (31) ◽  
pp. 20927-20935 ◽  
Author(s):  
Capucine Van Rechem ◽  
Brian R. Rood ◽  
Majid Touka ◽  
Sébastien Pinte ◽  
Mathias Jenal ◽  
...  
Keyword(s):  
Target Gene ◽  
Direct Target Gene ◽  
Direct Target

scholarly journals YTHDF2, a protein repressed by miR-145, regulates proliferation, apoptosis and migration in ovarian cancer cells

2020 ◽  
Author(s):  
Jie Li ◽  
Lei Wu ◽  
Meili Pei ◽  
Yun Zhang
Keyword(s):  
Ovarian Cancer ◽  
Feedback Loop ◽  
Target Gene ◽  
Epigenetic Modification ◽  
Ovarian Cancer Cells ◽  
Direct Target Gene ◽  
Direct Target ◽  
And Migration ◽  
Cancer Tissues ◽  
Proliferation And Migration

Abstract RNA methylation can reverse the methylation modification at RNA level, which is a kind of extremely important epigenetic modification. YTHDF2, as a reader of m6A modification, the function and mechanisms of in epithelial ovarian cancer(EOC) have not been elucidated so far. In this study, we demonstrated that YTHDF2 was significantly upregulated in EOC tissues compared with normal ovarian tissues, further function studies confirmed that YTHDF2 significantly promoted the proliferation and migration of EOC cell lines, and reduced the global mRNA m6A levels. Next, we found that the expression levels of miR-145 and YTHDF2 were inversely correlated in ovarian cancer tissues and cells, and YTHDF2 is the direct target gene of miR-145. Interestingly, there was a crucial crosstalk between miR-145 and YTHDF2 via a double-negative feedback loop. Overexpression of YTHDF2 rescues miR-145-induced reduction of proliferation and migration in EOC cells. To conclude, YTHDF2 and miR-145, as two crucial m6A regulators, are involved in the progression of EOC by indirectly modulating m6A levels. In view of these promising results, YTHDF2 and miR-145 may provide new insights into the carcinogenesis and new potential therapeutic targets for EOC.

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