scholarly journals Phosphorylation of Cdc25C by pp90Rsk Contributes to a G2 Cell Cycle Arrest in Xenopus Cycling Egg Extracts

Cell Cycle ◽  
2004 ◽  
Vol 4 (1) ◽  
pp. 148-154 ◽  
Author(s):  
Justin Chun ◽  
Andrew S-S Chau ◽  
Ferdinand G. Maingat ◽  
Stuart D. Edmonds ◽  
Hanne L. Ostergaard ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cycle Arrest ◽  
Egg Extracts ◽  
G2 Cell Cycle Arrest

scholarly journals G1 versus G2 cell cycle arrest after adriamycin-induced damage in mouse Swiss3T3 cells

FEBS Letters ◽  
1999 ◽  
Vol 461 (3) ◽  
pp. 299-305 ◽  
Author(s):  
Wai Yi Siu ◽  
Cain H Yam ◽  
Randy Y.C Poon
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cycle Arrest ◽  
G2 Cell Cycle Arrest

scholarly journals Muscle Stem Cells Undergo Extensive Clonal Drift during Tissue Growth via Meox1-Mediated Induction of G2 Cell-Cycle Arrest

2017 ◽  
Vol 21 (1) ◽  
pp. 107-119.e6 ◽  
Author(s):  
Phong Dang Nguyen ◽  
David Baruch Gurevich ◽  
Carmen Sonntag ◽  
Lucy Hersey ◽  
Sara Alaei ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Cell Cycle Arrest ◽  
Tissue Growth ◽  
Muscle Stem Cells ◽  
Cycle Arrest ◽  
G2 Cell Cycle Arrest

scholarly journals Critical role of PP2A-B56 family protein degradation in HIV-1 Vif mediated G2 cell cycle arrest

2020 ◽  
Vol 527 (1) ◽  
pp. 257-263
Author(s):  
Kayoko Nagata ◽  
Keisuke Shindo ◽  
Yusuke Matsui ◽  
Kotaro Shirakawa ◽  
Akifumi Takaori-Kondo
Keyword(s):  
Cell Cycle ◽  
Protein Degradation ◽  
Cell Cycle Arrest ◽  
Critical Role ◽  
Cycle Arrest ◽  
Family Protein ◽  
G2 Cell Cycle Arrest ◽  
Hiv 1

scholarly journals Weighted Correlation Network Analysis Reveals CDK2 as a Regulator of a Ubiquitous Environmental Toxin-Induced Cell-Cycle Arrest

Cells ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 143
Author(s):  
Virginie Dubourg ◽  
Alexander Nolze ◽  
Michael Kopf ◽  
Michael Gekle ◽  
Gerald Schwerdt
Keyword(s):  
Cell Cycle ◽  
Network Analysis ◽  
Cell Cycle Arrest ◽  
Regulation Of Gene Expression ◽  
Correlation Network ◽  
Food Contaminants ◽  
Proximal Tubule Cells ◽  
Cycle Arrest ◽  
G2 Cell Cycle Arrest ◽  
Weighted Correlation

Environmental food contaminants constitute a threat to human health. For instance, the globally spread mycotoxin Ochratoxin A (OTA) contributes to chronic kidney damage by affecting proximal tubule cells via unknown mechanisms. We applied a top-down approach to identify relevant toxicological mechanisms of OTA using RNA-sequencing followed by in-depth bioinformatics analysis and experimental validation. Differential expression analyses revealed that OTA led to the regulation of gene expression in kidney human cell lines, including for genes enriched in cell cycle-related pathways, and OTA-induced gap 1 and 2 (G1 and G2) cell-cycle arrests were observed. Weighted correlation network analysis highlighted cyclin dependent kinase 2 (CDK2) as a putative key regulator of this effect. CDK2 was downregulated by OTA exposure, and its overexpression partially blocked the OTA-induced G1 but not G2 cell-cycle arrest. We, therefore, propose CDK2 as one of the key regulators of the G1 cell-cycle arrest induced by low nanomolar concentrations of OTA.

Acute exposure of human lung cells to 1,3-butadiene diepoxide results in G1 and G2 cell cycle arrest

2005 ◽  
Vol 45 (4) ◽  
pp. 354-364 ◽  
Author(s):  
Michael Schmiederer ◽  
Eugene Knutson ◽  
Perpetua Muganda ◽  
Thomas Albrecht
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Human Lung ◽  
Acute Exposure ◽  
Lung Cells ◽  
Cycle Arrest ◽  
Human Lung Cells ◽  
G2 Cell Cycle Arrest

scholarly journals G2 Cell Cycle Arrest and Cyclophilin A in Lentiviral Gene Transfer

2006 ◽  
Vol 14 (4) ◽  
pp. 546-554 ◽  
Author(s):  
Shangming Zhang ◽  
Guiandre Joseph ◽  
Karen Pollok ◽  
Lionel Berthoux ◽  
Lakshmi Sastry ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Gene Transfer ◽  
Cell Cycle Arrest ◽  
Cyclophilin A ◽  
Cycle Arrest ◽  
G2 Cell Cycle Arrest
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