scholarly journals Chromosome 17p Deletion in Human Medulloblastoma: A Missing Checkpoint in the Hedgehog Pathway

Cell Cycle ◽  
2004 ◽  
Vol 3 (10) ◽  
pp. 1263-1266 ◽  
Author(s):  
Enrico De Smaele ◽  
Lucia Di Marcotullio ◽  
Elisabetta Ferretti ◽  
Isabella Screpanti ◽  
Edoardo Alesse ◽  
...  
Keyword(s):  
Hedgehog Pathway ◽  
Human Medulloblastoma ◽  
Chromosome 17P Deletion

scholarly journals Inhibition of the Sonic Hedgehog Pathway by Cyclopamine or GLI1 siRNA Reduces In Vivo Tumorigenesis of Human Medulloblastoma Cells Xenotransplanted to Immunodeficient Nude Mice

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Javier de la Rosa ◽  
Mónica Sánchez ◽  
Mónica Enguita-Germán ◽  
Ricardo García-López ◽  
Paula Schiapparelli ◽  
...  
Keyword(s):  
Sonic Hedgehog ◽  
Nude Mice ◽  
Hedgehog Pathway ◽  
Sonic Hedgehog Pathway ◽  
Human Medulloblastoma

442: Stromal Hedgehog Pathway Activity Accelerates Prostate Tumor Growth

2006 ◽  
Vol 175 (4S) ◽  
pp. 143-143
Author(s):  
Aubie Shaw ◽  
Jerry Gipp ◽  
Wade Bushman
Keyword(s):  
Tumor Growth ◽  
Prostate Tumor ◽  
Hedgehog Pathway ◽  
Pathway Activity

scholarly journals Upregulation of LINC01426 promotes the progression and stemness in lung adenocarcinoma by enhancing the level of SHH protein to activate the hedgehog pathway

2021 ◽  
Vol 12 (2) ◽  
Author(s):  
Xiaoli Liu ◽  
Zuwei Yin ◽  
Linping Xu ◽  
Huaimin Liu ◽  
Lifeng Jiang ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Bioinformatics Analysis ◽  
Epithelial Mesenchymal Transition ◽  
Mrna Level ◽  
Hedgehog Pathway ◽  
Biological Processes ◽  
Protein Coding ◽  
Mesenchymal Transition ◽  
Functional Roles ◽  
Rip Assay

AbstractLong noncoding RNAs (lncRNAs) play crucial roles in regulating a variety of biological processes in lung adenocarcinoma (LUAD). In our study, we mainly explored the functional roles of a novel lncRNA long intergenic non-protein coding RNA 1426 (LINC01426) in LUAD. We applied bioinformatics analysis to find the expression of LINC01426 was upregulated in LUAD tissue. Functionally, silencing of LINC01426 obviously suppressed the proliferation, migration, epithelial–mesenchymal transition (EMT), and stemness of LUAD cells. Then, we observed that LINC01426 functioned through the hedgehog pathway in LUAD. The effect of LINC01426 knockdown could be fully reversed by adding hedgehog pathway activator SAG. In addition, we proved that LINC01426 could not affect SHH transcription and its mRNA level. Pull-down sliver staining and RIP assay revealed that LINC01426 could interact with USP22. Ubiquitination assays manifested that LINC01426 and USP22 modulated SHH ubiquitination levels. Rescue assays verified that SHH overexpression rescued the cell growth, migration, and stemness suppressed by LINC01426 silencing. In conclusion, LINC01426 promotes LUAD progression by recruiting USP22 to stabilize SHH protein and thus activate the hedgehog pathway.

scholarly journals Propofol Inhibits the Proliferation, Migration, and Stem-like Properties of Bladder Cancer Mainly by Suppressing the Hedgehog Pathway

2021 ◽  
Vol 30 ◽  
pp. 096368972098511
Author(s):  
Gang Li ◽  
Xu Zhang ◽  
Xiangyang Guo ◽  
Yi Li ◽  
Chong Li
Keyword(s):  
Stem Cells ◽  
Bladder Cancer ◽  
Bladder Tumor ◽  
Therapeutic Agent ◽  
Tumor Formation ◽  
The Self ◽  
Hedgehog Pathway ◽  
Self Renewal ◽  
Intravenous Anesthetic ◽  
Novel Therapeutic

Bladder cancer is one of the most common malignancies. The existence of bladder cancer stem cells (BCSCs) has been suggested to underlie bladder tumor initiation and recurrence. Propofol is a commonly used intravenous anesthetic. Here, we find that propofol can dramatically block the activation of Hedgehog pathway in BCSCs. The propofol strongly repressed the growth of cancer cells. Attenuated proliferation and enhanced apoptosis of tumor cells were observed upon propofol stimulation. Furthermore, propofol reduced the self-renewal ability of BCSCs as well as the tumor formation. In conclusion, propofol is potentially used as a novel therapeutic agent for bladder cancer by targeting self-renewal through inhibiting Hedgehog pathway.

scholarly journals Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

2009 ◽  
Vol 361 (12) ◽  
pp. 1173-1178 ◽  
Author(s):  
Charles M. Rudin ◽  
Christine L. Hann ◽  
John Laterra ◽  
Robert L. Yauch ◽  
Christopher A. Callahan ◽  
...  
Keyword(s):  
Hedgehog Pathway ◽  
Hedgehog Pathway Inhibitor

Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma

2009 ◽  
Vol 361 (12) ◽  
pp. 1164-1172 ◽  
Author(s):  
Daniel D. Von Hoff ◽  
Patricia M. LoRusso ◽  
Charles M. Rudin ◽  
Josina C. Reddy ◽  
Robert L. Yauch ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Hedgehog Pathway ◽  
Advanced Basal Cell Carcinoma

scholarly journals Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies

2012 ◽  
Vol 3 (10) ◽  
pp. 808-813 ◽  
Author(s):  
Chris Dockendorff ◽  
Marek M. Nagiec ◽  
Michel Weïwer ◽  
Sara Buhrlage ◽  
Amal Ting ◽  
...  
Keyword(s):  
Mode Of Action ◽  
Hedgehog Pathway ◽  
Cellular Activity
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