scholarly journals Inhibition of the Sonic Hedgehog Pathway by Cyclopamine or GLI1 siRNA Reduces In Vivo Tumorigenesis of Human Medulloblastoma Cells Xenotransplanted to Immunodeficient Nude Mice

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Javier de la Rosa ◽  
Mónica Sánchez ◽  
Mónica Enguita-Germán ◽  
Ricardo García-López ◽  
Paula Schiapparelli ◽  
...  
Keyword(s):  
Sonic Hedgehog ◽  
Nude Mice ◽  
Hedgehog Pathway ◽  
Sonic Hedgehog Pathway ◽  
Human Medulloblastoma

scholarly journals Blockade of the sonic hedgehog pathway effectively inhibits the growth of hepatoma in mice: An in vivo study

2012 ◽  
Vol 4 (6) ◽  
pp. 1158-1162 ◽  
Author(s):  
KUO-SHYANG JENG ◽  
I-SHYAN SHEEN ◽  
WEN-JUEI JENG ◽  
MING-CHE YU ◽  
HSIN-HUA TSAI ◽  
...  
Keyword(s):  
Sonic Hedgehog ◽  
Hedgehog Pathway ◽  
In Vivo Study ◽  
Sonic Hedgehog Pathway

scholarly journals Baicalin Attenuates Alcoholic Liver Injury through Modulation of Hepatic Oxidative Stress, Inflammation and Sonic Hedgehog Pathway in Rats

2016 ◽  
Vol 39 (3) ◽  
pp. 1129-1140 ◽  
Author(s):  
Huifen Wang ◽  
Yanli Zhang ◽  
Ruxue Bai ◽  
Miao Wang ◽  
Shiyu Du
Keyword(s):  
Oxidative Stress ◽  
Liver Injury ◽  
Sonic Hedgehog ◽  
Inflammatory Responses ◽  
Hedgehog Pathway ◽  
Alcoholic Liver Injury ◽  
Sonic Hedgehog Pathway ◽  
Shh Pathway

Background/Aims: Lipid accumulation, inflammatory responses and oxidative stress have been implicated in the pathology of alcoholic liver disease (ALD). Targeting inhibition of these features may provide a promising therapeutic strategy for ALD. Baicalin, a flavonoid isolated from Scutellaria baicalensis Georgi, has been shown to exert a hepatoprotective effect. However, its effects on ALD remain obscure. This study was aimed to investigate the effects of baicalin on alcohol-induced liver injury and its related mechanisms. Methods: For in vivo experiments, rats were supplied intragastrical administration of alcohol continuously for 4 or 8 weeks, and then received baicalin treatment in the latter 4 weeks in the presence / absence of alcohol intake. Liver histology and function, inflammatory cytokines, oxidative mediators, and the components of the Sonic hedgehog pathway were evaluated. For in vitro experiments, alcohol-stimulated human normal liver cells LO2 were used. Results: Baicalin treatment significantly alleviated alcoholic liver injury, improved liver function impaired by alcohol, and inhibited hepatocytes apoptosis. In addition, baicalin decreased the expression levels of proinflammatory cytokines TNF-α, IL-1β, IL-6) and malonyldialdehyde (MDA), and increased the activities of antioxidant enzymes SOD and GSH-Px. Furthermore, baicalin modulated the activation of Sonic hedgehog (Shh) pathway. Administration of baicalin upregulated the expression of sonic hedgehog (Shh), patched (Ptc), Smoothened (Smo), and Glioblastoma-1(Gli-1). Blockade of the Shh pathway in cyclopamine abolished the effects of baicalin in vitro. Conclusion: Both in vivo and in vitro experimental results indicate that baicalin exerts hepatoprotective roles in alcohol-induced liver injury through inhibiting oxidative stress, inflammatory response, and the regulation of the Shh pathway.

scholarly journals In Vivo Enhanced Expression of Patched Dampens the Sonic Hedgehog Pathway

2002 ◽  
Vol 6 (2) ◽  
pp. 258-264 ◽  
Author(s):  
Ivan Bergstein ◽  
Philip L Leopold ◽  
Noboru Sato ◽  
Andrei A Panteleyev ◽  
Angela M Christiano ◽  
...  
Keyword(s):  
Sonic Hedgehog ◽  
Hedgehog Pathway ◽  
Sonic Hedgehog Pathway ◽  
Enhanced Expression

scholarly journals Mutations of the Sonic Hedgehog Pathway Underlie Hypothalamic Hamartoma with Gelastic Epilepsy

2016 ◽  
Vol 99 (2) ◽  
pp. 423-429 ◽  
Author(s):  
Michael S. Hildebrand ◽  
Nicole G. Griffin ◽  
John A. Damiano ◽  
Elisa J. Cops ◽  
Rosemary Burgess ◽  
...  
Keyword(s):  
Sonic Hedgehog ◽  
Hedgehog Pathway ◽  
Hypothalamic Hamartoma ◽  
Sonic Hedgehog Pathway ◽  
Gelastic Epilepsy

Cadmium‐induced neurodegeneration and activation of noncanonical sonic hedgehog pathway in rat cerebellum

2018 ◽  
Vol 33 (4) ◽  
pp. e22274
Author(s):  
Mubeena Mariyath P. M. ◽  
Mehdi H. Shahi ◽  
Mohd Tayyab ◽  
Shirin Farheen ◽  
Nabeela Khanam ◽  
...  
Keyword(s):  
Sonic Hedgehog ◽  
Hedgehog Pathway ◽  
Sonic Hedgehog Pathway ◽  
Rat Cerebellum

Sonic Hedgehog Pathway as a Target for Therapy in Angiogenesis-Related Diseases

2009 ◽  
Vol 4 (1) ◽  
pp. 31-45 ◽  
Author(s):  
Chiara Porro ◽  
Raffaella Soleti ◽  
Tarek Benameur ◽  
Angela Maffione ◽  
Ramaroson Andriantsitohaina ◽  
...  
Keyword(s):  
Sonic Hedgehog ◽  
Hedgehog Pathway ◽  
Sonic Hedgehog Pathway

scholarly journals ThemiR-17∼92cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma

2009 ◽  
Vol 106 (8) ◽  
pp. 2812-2817 ◽  
Author(s):  
Tamar Uziel ◽  
Fedor V. Karginov ◽  
Suqing Xie ◽  
Joel S. Parker ◽  
Yong-Dong Wang ◽  
...  
Keyword(s):  
Sonic Hedgehog ◽  
Hedgehog Pathway ◽  
Sonic Hedgehog Pathway
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