scholarly journals Dodging two bullets with one dsRNA-binding protein

Cell Cycle ◽  
2013 ◽  
Vol 13 (3) ◽  
pp. 345-346 ◽  
Author(s):  
Reyad A Elbarbary ◽  
Lynne E Maquat
Keyword(s):  
Binding Protein ◽  
Dsrna Binding ◽  
Dsrna Binding Protein

Control of dengue virus in the midgut of Aedes aegypti by ectopic expression of the dsRNA-binding protein Loqs2

2018 ◽  
Vol 3 (12) ◽  
pp. 1385-1393 ◽  
Author(s):  
Roenick P. Olmo ◽  
Alvaro G. A. Ferreira ◽  
Tatiane C. Izidoro-Toledo ◽  
Eric R. G. R. Aguiar ◽  
Isaque J. S. de Faria ◽  
...  
Keyword(s):  
Aedes Aegypti ◽  
Dengue Virus ◽  
Binding Protein ◽  
Ectopic Expression ◽  
Dsrna Binding ◽  
Dsrna Binding Protein

scholarly journals The dsRNA Binding Protein RDE-4 Interacts with RDE-1, DCR-1, and a DExH-Box Helicase to Direct RNAi in C. elegans

Cell ◽  
2002 ◽  
Vol 109 (7) ◽  
pp. 861-871 ◽  
Author(s):  
Hiroaki Tabara ◽  
Erbay Yigit ◽  
Haruhiko Siomi ◽  
Craig C. Mello
Keyword(s):  
Binding Protein ◽  
C Elegans ◽  
Dsrna Binding ◽  
Dsrna Binding Protein

scholarly journals A specific dsRNA-binding protein complex selectively sequesters endogenous inverted-repeat siRNA precursors and inhibits their processing

2016 ◽  
pp. gkw1264 ◽  
Author(s):  
Thomas Montavon ◽  
Yerim Kwon ◽  
Aude Zimmermann ◽  
Philippe Hammann ◽  
Timothée Vincent ◽  
...  
Keyword(s):  
Protein Complex ◽  
Inverted Repeat ◽  
Binding Protein ◽  
Dsrna Binding ◽  
Dsrna Binding Protein

scholarly journals A dsRNA-binding protein MdDRB1 associated with miRNA biogenesis modifies adventitious rooting and tree architecture in apple

2013 ◽  
Vol 12 (2) ◽  
pp. 183-192 ◽  
Author(s):  
Chun-Xiang You ◽  
Qiang Zhao ◽  
Xiao-Fei Wang ◽  
Xing-Bin Xie ◽  
Xiao-Ming Feng ◽  
...  
Keyword(s):  
Binding Protein ◽  
Adventitious Rooting ◽  
Tree Architecture ◽  
Mirna Biogenesis ◽  
Dsrna Binding ◽  
Dsrna Binding Protein

scholarly journals Double-Stranded-RNA-Binding Protein 2 Participates in Antiviral Defense

2020 ◽  
Vol 94 (11) ◽  
Author(s):  
Károly Fátyol ◽  
Katalin Anna Fekete ◽  
Márta Ludman
Keyword(s):  
Rna Interference ◽  
Virus Infection ◽  
Nicotiana Benthamiana ◽  
Rna Binding ◽  
Binding Protein ◽  
Systemic Necrosis ◽  
Double Stranded Rna ◽  
Content Type ◽  
Dsrna Binding ◽  
Dsrna Binding Protein

ABSTRACT Double-stranded RNA (dsRNA) is a common pattern formed during the replication of both RNA and DNA viruses. Perception of virus-derived dsRNAs by specialized receptor molecules leads to the activation of various antiviral measures. In plants, these defensive processes include the adaptive RNA interference (RNAi) pathway and innate pattern-triggered immune (PTI) responses. While details of the former process have been well established in recent years, the latter are still only partially understood at the molecular level. Nonetheless, emerging data suggest extensive cross talk between the different antiviral mechanisms. Here, we demonstrate that dsRNA-binding protein 2 (DRB2) of Nicotiana benthamiana plays a direct role in potato virus X (PVX)-elicited systemic necrosis. These results establish that DRB2, a known component of RNAi, is also involved in a virus-induced PTI response. In addition, our findings suggest that RNA-dependent polymerase 6 (RDR6)-dependent dsRNAs play an important role in the triggering of PVX-induced systemic necrosis. Based on our data, a model is formulated whereby competition between different DRB proteins for virus-derived dsRNAs helps establish the dominant antiviral pathways that are activated in response to virus infection. IMPORTANCE Plants employ multiple defense mechanisms to restrict viral infections, among which RNA interference is the best understood. The activation of innate immunity often leads to both local and systemic necrotic responses, which confine the virus to the infected cells and can also provide resistance to distal, noninfected parts of the organism. Systemic necrosis, which is regarded as a special form of the local hypersensitive response, results in necrosis of the apical stem region, usually causing the death of the plant. Here, we provide evidence that the dsRNA-binding protein 2 of Nicotiana benthamiana plays an important role in virus-induced systemic necrosis. Our findings are not only compatible with the recent hypothesis that DRB proteins act as viral invasion sensors but also extends it by proposing that DRBs play a critical role in establishing the dominant antiviral measures that are triggered during virus infection.

scholarly journals Anti-apoptotic and oncogenic properties of the dsRNA-binding protein of vaccinia virus, E3L

Oncogene ◽  
2002 ◽  
Vol 21 (55) ◽  
pp. 8379-8387 ◽  
Author(s):  
Maria Angel García ◽  
Susana Guerra ◽  
Jesús Gil ◽  
Victoria Jimenez ◽  
Mariano Esteban
Keyword(s):  
Vaccinia Virus ◽  
Binding Protein ◽  
Dsrna Binding ◽  
Dsrna Binding Protein
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