A Mutation in the Arabidopsis HYL1 Gene Encoding a dsRNA Binding Protein Affects Responses to Abscisic Acid, Auxin, and Cytokinin

2000 ◽  
Vol 12 (12) ◽  
pp. 2351 ◽  
Author(s):  
Cheng Lu ◽  
Nina Fedoroff
Keyword(s):  
Abscisic Acid ◽  
Binding Protein ◽  
Gene Encoding ◽  
Dsrna Binding ◽  
Dsrna Binding Protein

scholarly journals The origin and evolution of loqs2: a gene encoding an antiviral dsRNA binding protein in Aedes mosquitoes

2021 ◽  
Author(s):  
Carlos F. Estevez-Castro ◽  
Murillo F. Rodrigues ◽  
Antinéa Babarit ◽  
Flávia Viana Ferreira ◽  
Eric Marois ◽  
...  
Keyword(s):  
Rna Binding ◽  
Binding Protein ◽  
Mosquito Species ◽  
Rnai Pathway ◽  
Gene Encoding ◽  
Origin And Evolution ◽  
Larval Stages ◽  
Dsrna Binding ◽  
Dsrna Binding Protein ◽  
Antiviral Gene

Mosquito borne viruses such as dengue, Zika, yellow fever and Chikungunya cause millions of infections every year. These viruses are mostly transmitted by two urban-adapted mosquito species, Aedes aegypti and Aedes albopictus, that appear to be more permissive to arbovirus infections compared to closely related species. Although mechanistic understanding remains, Aedes mosquitoes may have evolved specialized antiviral mechanisms that potentially contribute to the low impact of viral infection. Recently, we reported the identification of an Aedes specific double-stranded RNA binding protein (dsRBP), named Loqs2, that is involved in the control of infection by dengue and Zika viruses in Ae. aegypti. Loqs2 interacts with two important co-factors of the RNA interference (RNAi) pathway, Loquacious (Loqs) and R2D2, and seems to be a strong regulator of the antiviral defense. However, the origin and evolution of loqs2 remains unclear. Here, we describe that loqs2 likely originated from two independent duplications of the first dsRNA binding domain (dsRBD) of loquacious that occurred before the radiation of the Aedes Stegomya subgenus. After its origin, our analyses suggest that loqs2 evolved by relaxed positive selection towards neofunctionalization. In fact, loqs2 is evolving at a faster pace compared to other RNAi components such as loquacious, r2d2 and Dicer-2 in Aedes mosquitoes. Unlike loquacious, transcriptomic analysis showed that loqs2 expression is tightly regulated, almost restricted to reproductive tissues in Ae. aegypti and Ae. albopictus. Transgenic mosquitoes engineered to ubiquitously express loqs2 show massive dysregulation of stress response genes and undergo developmental arrest at larval stages. Overall, our results uncover the possible origin and neofunctionalization of a novel antiviral gene, loqs2, in Aedes mosquitoes that ultimately may contribute to their effectiveness as vectors for arboviruses.

scholarly journals Dodging two bullets with one dsRNA-binding protein

Cell Cycle ◽  
2013 ◽  
Vol 13 (3) ◽  
pp. 345-346 ◽  
Author(s):  
Reyad A Elbarbary ◽  
Lynne E Maquat
Keyword(s):  
Binding Protein ◽  
Dsrna Binding ◽  
Dsrna Binding Protein

Control of dengue virus in the midgut of Aedes aegypti by ectopic expression of the dsRNA-binding protein Loqs2

2018 ◽  
Vol 3 (12) ◽  
pp. 1385-1393 ◽  
Author(s):  
Roenick P. Olmo ◽  
Alvaro G. A. Ferreira ◽  
Tatiane C. Izidoro-Toledo ◽  
Eric R. G. R. Aguiar ◽  
Isaque J. S. de Faria ◽  
...  
Keyword(s):  
Aedes Aegypti ◽  
Dengue Virus ◽  
Binding Protein ◽  
Ectopic Expression ◽  
Dsrna Binding ◽  
Dsrna Binding Protein

scholarly journals An Arabidopsis Gene Encoding a Ca2+-Binding Protein is Induced by Abscisic Acid during Dehydration

2000 ◽  
Vol 41 (7) ◽  
pp. 898-903 ◽  
Author(s):  
Seiji Takahashi ◽  
Takeshi Katagiri ◽  
Kazuko Yamaguchi-Shinozaki ◽  
Kazuo Shinozaki
Keyword(s):  
Abscisic Acid ◽  
Binding Protein ◽  
Gene Encoding ◽  
Arabidopsis Gene

scholarly journals The dsRNA Binding Protein RDE-4 Interacts with RDE-1, DCR-1, and a DExH-Box Helicase to Direct RNAi in C. elegans

Cell ◽  
2002 ◽  
Vol 109 (7) ◽  
pp. 861-871 ◽  
Author(s):  
Hiroaki Tabara ◽  
Erbay Yigit ◽  
Haruhiko Siomi ◽  
Craig C. Mello
Keyword(s):  
Binding Protein ◽  
C Elegans ◽  
Dsrna Binding ◽  
Dsrna Binding Protein

scholarly journals A specific dsRNA-binding protein complex selectively sequesters endogenous inverted-repeat siRNA precursors and inhibits their processing

2016 ◽  
pp. gkw1264 ◽  
Author(s):  
Thomas Montavon ◽  
Yerim Kwon ◽  
Aude Zimmermann ◽  
Philippe Hammann ◽  
Timothée Vincent ◽  
...  
Keyword(s):  
Protein Complex ◽  
Inverted Repeat ◽  
Binding Protein ◽  
Dsrna Binding ◽  
Dsrna Binding Protein

scholarly journals A dsRNA-binding protein MdDRB1 associated with miRNA biogenesis modifies adventitious rooting and tree architecture in apple

2013 ◽  
Vol 12 (2) ◽  
pp. 183-192 ◽  
Author(s):  
Chun-Xiang You ◽  
Qiang Zhao ◽  
Xiao-Fei Wang ◽  
Xing-Bin Xie ◽  
Xiao-Ming Feng ◽  
...  
Keyword(s):  
Binding Protein ◽  
Adventitious Rooting ◽  
Tree Architecture ◽  
Mirna Biogenesis ◽  
Dsrna Binding ◽  
Dsrna Binding Protein
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