scholarly journals PACSIN 2 represses cellular migration through direct association with cyclin D1 but not its alternate splice form cyclin D1b

Cell Cycle ◽  
2011 ◽  
Vol 10 (1) ◽  
pp. 73-81 ◽  
Author(s):  
Hui Meng ◽  
Lifeng Tian ◽  
Jie Zhou ◽  
Zhiping Li ◽  
Xuanmao Jiao ◽  
...  
Keyword(s):  
Cyclin D1 ◽  
Cellular Migration ◽  
Splice Form ◽  
Alternate Splice ◽  
Direct Association

scholarly journals Minireview: Cyclin D1: Normal and Abnormal Functions

Endocrinology ◽  
2004 ◽  
Vol 145 (12) ◽  
pp. 5439-5447 ◽  
Author(s):  
Maofu Fu ◽  
Chenguang Wang ◽  
Zhiping Li ◽  
Toshiyuki Sakamaki ◽  
Richard G. Pestell
Keyword(s):  
Cell Cycle ◽  
Cyclin D1 ◽  
Chromatin Remodeling ◽  
Original Description ◽  
Cellular Migration ◽  
Regulatory Subunit ◽  
Cyclin Dependent Kinase ◽  
Fat Cell ◽  
Independent Functions ◽  
Cancer Côlon

Abstract Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1-S phase of the cell cycle. Amplification or overexpression of cyclin D1 plays pivotal roles in the development of a subset of human cancers including parathyroid adenoma, breast cancer, colon cancer, lymphoma, melanoma, and prostate cancer. Of the three D-type cyclins, each of which binds cyclin-dependent kinase (CDK), it is cyclin D1 overexpression that is predominantly associated with human tumorigenesis and cellular metastases. In recent years accumulating evidence suggests that in addition to its original description as a CDK-dependent regulator of the cell cycle, cyclin D1 also conveys cell cycle or CDK-independent functions. Cyclin D1 associates with, and regulates activity of, transcription factors, coactivators and corepressors that govern histone acetylation and chromatin remodeling proteins. The recent findings that cyclin D1 regulates cellular metabolism, fat cell differentiation and cellular migration have refocused attention on novel functions of cyclin D1 and their possible role in tumorigenesis. In this review, both the classic and novel functions of cyclin D1 are discussed with emphasis on the CDK-independent functions of cyclin D1.

scholarly journals Identification of an alternate splice form of tapasin in human melanoma

2010 ◽  
Vol 71 (10) ◽  
pp. 1018-1026 ◽  
Author(s):  
Alan Belicha-Villanueva ◽  
Michelle Golding ◽  
Sarah McEvoy ◽  
Nilofar Sarvaiya ◽  
Peter Cresswell ◽  
...  
Keyword(s):  
Human Melanoma ◽  
Splice Form ◽  
Alternate Splice

scholarly journals Cyclin D1 Induction of Cellular Migration Requires p27KIP1

2006 ◽  
Vol 66 (20) ◽  
pp. 9986-9994 ◽  
Author(s):  
Zhiping Li ◽  
Xuanmao Jiao ◽  
Chenguang Wang ◽  
Xiaoming Ju ◽  
Yinan Lu ◽  
...  
Keyword(s):  
Cyclin D1 ◽  
Cellular Migration

scholarly journals The membrane-associated form of cyclin D1 enhances cellular invasion

Oncogenesis ◽  
2020 ◽  
Vol 9 (9) ◽  
Author(s):  
Ke Chen ◽  
Xuanmao Jiao ◽  
Anthony Ashton ◽  
Agnese Di Rocco ◽  
Timothy G. Pestell ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cyclin D1 ◽  
Cell Cycle Progression ◽  
Cellular Proliferation ◽  
Cytoplasmic Membrane ◽  
Cellular Migration ◽  
Serine Threonine Kinase ◽  
Cycle Progression ◽  
17Β Estradiol ◽  
Localized Form

Abstract The essential G1-cyclin, CCND1, is a collaborative nuclear oncogene that is frequently overexpressed in cancer. D-type cyclins bind and activate CDK4 and CDK6 thereby contributing to G1–S cell-cycle progression. In addition to the nucleus, herein cyclin D1 was also located in the cytoplasmic membrane. In contrast with the nuclear-localized form of cyclin D1 (cyclin D1NL), the cytoplasmic membrane-localized form of cyclin D1 (cyclin D1MEM) induced transwell migration and the velocity of cellular migration. The cyclin D1MEM was sufficient to induce G1–S cell-cycle progression, cellular proliferation, and colony formation. The cyclin D1MEM was sufficient to induce phosphorylation of the serine threonine kinase Akt (Ser473) and augmented extranuclear localized 17β-estradiol dendrimer conjugate (EDC)-mediated phosphorylation of Akt (Ser473). These studies suggest distinct subcellular compartments of cell cycle proteins may convey distinct functions.

scholarly journals Cyclin D1 Regulates Cellular Migration through the Inhibition of Thrombospondin 1 and ROCK Signaling

2006 ◽  
Vol 26 (11) ◽  
pp. 4240-4256 ◽  
Author(s):  
Zhiping Li ◽  
Chenguang Wang ◽  
Xuanmao Jiao ◽  
Yinan Lu ◽  
Maofu Fu ◽  
...  
Keyword(s):  
Cyclin D1 ◽  
Rho Gtpases ◽  
Mutational Analysis ◽  
Cellular Adhesion ◽  
Cellular Migration ◽  
Metastasis Suppressor ◽  
Lim Kinase ◽  
Retroviral Transduction ◽  
Myosin Light Chain 2 ◽  
Thrombospondin 1

ABSTRACT Cyclin D1 is overexpressed in human tumors, correlating with cellular metastasis, and is induced by activating Rho GTPases. Herein, cyclin D1-deficient mouse embryo fibroblasts (MEFs) exhibited increased adhesion and decreased motility compared with wild-type MEFs. Retroviral transduction of cyclin D1 reversed these phenotypes. Mutational analysis of cyclin D1 demonstrated that its effects on cellular adhesion and migration were independent of the pRb and p160 coactivator binding domains. Genomewide expression arrays identified a subset of genes regulated by cyclin D1, including Rho-activated kinase II (ROCKII) and thrombospondin 1 (TSP-1). cyclin D1 −/− cells showed increased Rho GTP and ROCKII activity and signaling, with increased phosphorylation of LIM kinase, cofilin (Ser3), and myosin light chain 2 (Thr18/Ser19). Cyclin D1 repressed ROCKII and TSP-1 expression, and the migratory defect of cyclin D1 −/− cells was reversed by ROCK inhibition or TSP-1 immunoneutralizing antibodies. cyclin E knockin to the cyclin D1 −/− MEFs rescued the DNA synthesis defect of cyclin D1 −/− MEFs but did not rescue either the migration defect or the abundance of ROCKII. Cyclin D1 promotes cellular motility through inhibiting ROCK signaling and repressing the metastasis suppressor TSP-1.

805: High-Level Cyclin D1 is Associated with High Gleason Grade and Predicts Worse Biochemical-Free Survival in Prostate Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 260-260
Author(s):  
Rile Li ◽  
Hong Dai ◽  
Thomas M. Wheeler ◽  
Anna Frolov ◽  
Gustavo Ayala
Keyword(s):  
Prostate Cancer ◽  
Cyclin D1 ◽  
Gleason Grade ◽  
Free Survival ◽  
High Level
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