HAb18G/CD147 enhances cell proliferation by promoting G0/G1 to S transition by ERK1/2 dependent cyclin D1 synthesis in human hepatoma cells

2010 ◽  
Vol 34 (8) ◽  
pp. S45-S45
Author(s):  
Yunshan Guo ◽  
Juan Tang ◽  
Zhinan Chenand Jianli Jiang
Keyword(s):  
Cell Proliferation ◽  
Cyclin D1 ◽  
Hepatoma Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Cells

The KLF6 Super Enhancer Modulates Cell Proliferation via MiR-1301 in Human Hepatoma Cells

MicroRNA ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 64-69 ◽  
Author(s):  
KumChol Ri ◽  
Chol Kim ◽  
CholJin Pak ◽  
PhyongChol Ri ◽  
HyonChol Om
Keyword(s):  
Cell Proliferation ◽  
Cellular Proliferation ◽  
Hepatoma Cells ◽  
Regulation Mechanism ◽  
Dependent Manner ◽  
Human Hepatoma ◽  
Human Hepatoma Cells ◽  
Over Expression ◽  
Super Enhancer ◽  
Engineering Changes

Background: Recent studies have attempted to elucidate the function of super enhancers by means of microRNAs. Although the functional outcomes of miR-1301 have become clearer, the pathways that regulate the expressions of miR-1301 remain unclear. Objective: The objective of this paper was to consider the pathway regulating expression of miR- 1301 and miR-1301 signaling pathways with the inhibition of cell proliferation. Methods: In this study, we prepared the cell clones that the KLF6 super enhancer was deleted by means of the CRISPR/Cas9 system-mediated genetic engineering. Changes in miR-1301 expression after the deletion of the KLF6 super enhancer were evaluated by RT-PCR analysis, and the signal pathway of miR-1301 with inhibition of the cell proliferation was examined using RNA interference technology. Results: The results showed that miR-1301 expression was significantly increased after the deletion of the KLF6 super enhancer. Over-expression of miR-1301 induced by deletion of the KLF6 super enhancer also regulated the expression of p21 and p53 in human hepatoma cells. functional modeling of findings using siRNA specific to miR-1301 showed that expression level changes had direct biological effects on cellular proliferation in Human hepatoma cells. Furthermore, cellular proliferation assay was shown to be directly associated with miR-1301 levels. Conclusion: As a result, it was demonstrated that the over-expression of miR-1301 induced by the disruption of the KLF6 super enhancer leads to a significant inhibition of proliferation in HepG2 cells. Moreover, it was demonstrated that the KLF6 super enhancer regulates the cell-proliferative effects which are mediated, at least in part, by the induction of p21and p53 in a p53-dependent manner. Our results provide the functional significance of miR-1301 in understanding the transcriptional regulation mechanism of the KLF6 super enhancer.

scholarly journals Effects of cell proliferation on the uptake of transferrin-bound iron by human hepatoma cells

Hepatology ◽  
2003 ◽  
Vol 38 (4) ◽  
pp. 967-977 ◽  
Author(s):  
Adrian W. M. Lee ◽  
Phillip S. Oates ◽  
Deborah Trinder
Keyword(s):  
Cell Proliferation ◽  
Hepatoma Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Cells

Gene silencing of TKTL1 by RNAi inhibits cell proliferation in human hepatoma cells

2007 ◽  
Vol 253 (1) ◽  
pp. 108-114 ◽  
Author(s):  
Song Zhang ◽  
Ju-Hong Yang ◽  
Chang-Kai Guo ◽  
Peng-cheng Cai
Keyword(s):  
Cell Proliferation ◽  
Gene Silencing ◽  
Hepatoma Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Cells

Isoliquiritigenin Inhibits Cell Proliferation and Induces Apoptosis in Human Hepatoma Cells

Planta Medica ◽  
2005 ◽  
Vol 71 (2) ◽  
pp. 130-134 ◽  
Author(s):  
Ya-Ling Hsu ◽  
Po-Lin Kuo ◽  
Liang-Tzung Lin ◽  
Chun-Ching Lin
Keyword(s):  
Cell Proliferation ◽  
Hepatoma Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Cells

Identification of UAP1L1 as a critical factor for protein O-GlcNAcylation and cell proliferation in human hepatoma cells

Oncogene ◽  
2018 ◽  
Vol 38 (3) ◽  
pp. 317-331 ◽  
Author(s):  
Ching-Yu Lai ◽  
Hsuan Liu ◽  
Kai Xuan Tin ◽  
Yi Huang ◽  
Kun-Hai Yeh ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Critical Factor ◽  
Hepatoma Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Cells

Inhibitory effect of prostaglandin Δ12-PGJ2 on cell proliferation and α-fetoprotein expression in HuH-7 human hepatoma cells

1992 ◽  
Vol 43 (2) ◽  
pp. 189-197 ◽  
Author(s):  
S. Mitsuoka ◽  
A. Otsuru ◽  
K. Nakao ◽  
T. Tsutsumi ◽  
S. Tsuruta ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Inhibitory Effect ◽  
Hepatoma Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Cells

scholarly journals Small antisense RNA to cyclin D1 generated by pre-tRNA splicing inhibits growth of human hepatoma cells

FEBS Letters ◽  
2004 ◽  
Vol 576 (3) ◽  
pp. 481-486 ◽  
Author(s):  
Dazhi Lai ◽  
Shaojie Weng ◽  
Cui'e Wang ◽  
Lianquan Qi ◽  
Changming Yu ◽  
...  
Keyword(s):  
Cyclin D1 ◽  
Antisense Rna ◽  
Hepatoma Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Cells ◽  
Trna Splicing

scholarly journals Berberine Suppresses Cyclin D1 Expression through Proteasomal Degradation in Human Hepatoma Cells

2016 ◽  
Vol 17 (11) ◽  
pp. 1899 ◽  
Author(s):  
Ning Wang ◽  
Xuanbin Wang ◽  
Hor-Yue Tan ◽  
Sha Li ◽  
Chi Tsang ◽  
...  
Keyword(s):  
Cyclin D1 ◽  
Proteasomal Degradation ◽  
Hepatoma Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Cells
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