scholarly journals Role of the actin-binding protein profilin1 in radial migration and glial cell adhesion of granule neurons in the cerebellum

2012 ◽  
Vol 6 (1) ◽  
pp. 13-17 ◽  
Author(s):  
Marco B. Rust ◽  
Jan A. Kullmann ◽  
Walter Witke
2001 ◽  
Vol 12 (6) ◽  
pp. 1595-1609 ◽  
Author(s):  
Shigekazu Yokoyama ◽  
Kouichi Tachibana ◽  
Hiroyuki Nakanishi ◽  
Yasunori Yamamoto ◽  
Kenji Irie ◽  
...  

ZO-1 is an actin filament (F-actin)–binding protein that localizes to tight junctions and connects claudin to the actin cytoskeleton in epithelial cells. In nonepithelial cells that have no tight junctions, ZO-1 localizes to adherens junctions (AJs) and may connect cadherin to the actin cytoskeleton indirectly through β- and α-catenins as one of many F-actin–binding proteins. Nectin is an immunoglobulin-like adhesion molecule that localizes to AJs and is associated with the actin cytoskeleton through afadin, an F-actin–binding protein. Ponsin is an afadin- and vinculin-binding protein that also localizes to AJs. The nectin-afadin complex has a potency to recruit the E-cadherin–β-catenin complex through α-catenin in a manner independent of ponsin. By the use of cadherin-deficient L cell lines stably expressing various components of the cadherin-catenin and nectin-afadin systems, and α-catenin–deficient F9 cell lines, we examined here whether nectin recruits ZO-1 to nectin-based cell-cell adhesion sites. Nectin showed a potency to recruit not only α-catenin but also ZO-1 to nectin-based cell-cell adhesion sites. This recruitment of ZO-1 was dependent on afadin but independent of α-catenin and ponsin. These results indicate that ZO-1 localizes to cadherin-based AJs through interactions not only with α-catenin but also with the nectin-afadin system.


2002 ◽  
Vol 25 (7) ◽  
pp. 837-844 ◽  
Author(s):  
Saotomo Itoh ◽  
Kensuke Suzuki ◽  
Jun Nishihata ◽  
Mitsusada Iwasa ◽  
Teruaki Oku ◽  
...  

1987 ◽  
Vol 163 (3) ◽  
pp. 467-471 ◽  
Author(s):  
Masao NOMURA ◽  
Kunihiko YOSHIKAWA ◽  
Toshihiko TANAKA ◽  
Kenji SOBUE ◽  
Koscak MARUYAMA

2006 ◽  
Vol 45 (3B) ◽  
pp. 2328-2332 ◽  
Author(s):  
Kosaku Kato ◽  
Yukiko Ohmori ◽  
Takeomi Mizutani ◽  
Hisashi Haga ◽  
Kazuyo Ohashi ◽  
...  

1998 ◽  
Vol 273 (3) ◽  
pp. 1689-1698 ◽  
Author(s):  
Michael Glogauer ◽  
Pam Arora ◽  
Deborah Chou ◽  
Paul A. Janmey ◽  
Gregory P. Downey ◽  
...  

2001 ◽  
Vol 359 (2) ◽  
pp. 255 ◽  
Author(s):  
Patrick PROVOST ◽  
Johanne DOUCET ◽  
Alexander STOCK ◽  
Günther GERISCH ◽  
Bengt SAMUELSSON ◽  
...  

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Matthias Hiermaier ◽  
Marie‐Therès Wanuske ◽  
Franziska Vielmuth ◽  
Jens Waschke ◽  
Volker Spindler

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