scholarly journals The Role of Actin-binding Protein 280 in Integrin-dependent Mechanoprotection

1998 ◽  
Vol 273 (3) ◽  
pp. 1689-1698 ◽  
Author(s):  
Michael Glogauer ◽  
Pam Arora ◽  
Deborah Chou ◽  
Paul A. Janmey ◽  
Gregory P. Downey ◽  
...  
Keyword(s):  
Binding Protein ◽  
Actin Binding ◽  
Actin Binding Protein

scholarly journals The Role of Protein Kinase C in the Transient Association of p57, a Coronin Family Actin-Binding Protein, with Phagosomes

2002 ◽  
Vol 25 (7) ◽  
pp. 837-844 ◽  
Author(s):  
Saotomo Itoh ◽  
Kensuke Suzuki ◽  
Jun Nishihata ◽  
Mitsusada Iwasa ◽  
Teruaki Oku ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Binding Protein ◽  
Actin Binding ◽  
Actin Binding Protein ◽  
Kinase C

The role of tropomyosin in the interactions of F-actin with caldesmon and actin-binding protein (or filamin)

1987 ◽  
Vol 163 (3) ◽  
pp. 467-471 ◽  
Author(s):  
Masao NOMURA ◽  
Kunihiko YOSHIKAWA ◽  
Toshihiko TANAKA ◽  
Kenji SOBUE ◽  
Koscak MARUYAMA
Keyword(s):  
Binding Protein ◽  
Actin Binding ◽  
Actin Binding Protein

The Role of Actin-Binding Protein Filamin A in Cellular Stiffness and Morphology Studied by Wide-Range Scanning Probe Microscopy

2006 ◽  
Vol 45 (3B) ◽  
pp. 2328-2332 ◽  
Author(s):  
Kosaku Kato ◽  
Yukiko Ohmori ◽  
Takeomi Mizutani ◽  
Hisashi Haga ◽  
Kazuyo Ohashi ◽  
...  
Keyword(s):  
Scanning Probe Microscopy ◽  
Binding Protein ◽  
Scanning Probe ◽  
Actin Binding ◽  
Filamin A ◽  
Probe Microscopy ◽  
Actin Binding Protein ◽  
Wide Range ◽  
Range Scanning

scholarly journals Coactosin-like protein, a human F-actin-binding protein: critical role of lysine-75

2001 ◽  
Vol 359 (2) ◽  
pp. 255 ◽  
Author(s):  
Patrick PROVOST ◽  
Johanne DOUCET ◽  
Alexander STOCK ◽  
Günther GERISCH ◽  
Bengt SAMUELSSON ◽  
...  
Keyword(s):  
Binding Protein ◽  
Critical Role ◽  
Protein A ◽  
Actin Binding ◽  
Actin Binding Protein

scholarly journals The Role of the Actin‐binding Protein α‐Adducin for Desmosome Turnover and Keratinocyte Adhesive Function

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Matthias Hiermaier ◽  
Marie‐Therès Wanuske ◽  
Franziska Vielmuth ◽  
Jens Waschke ◽  
Volker Spindler
Keyword(s):  
Binding Protein ◽  
Actin Binding ◽  
Actin Binding Protein

scholarly journals A Pan-Cancer Analysis of the Oncogenic Role of Twinfilin Actin Binding Protein 1 in Human Tumors

2021 ◽  
Vol 11 ◽  
Author(s):  
Gengwei Huo ◽  
Yali Wang ◽  
Jinliang Chen ◽  
Ying Song ◽  
Cuicui Zhang ◽  
...  
Keyword(s):  
Binding Protein ◽  
Gene Expression Omnibus ◽  
Human Tumors ◽  
The Cancer Genome Atlas ◽  
Actin Binding ◽  
Driver Gene ◽  
Comprehensive Overview ◽  
Actin Binding Protein ◽  
Pan Cancer

BackgroundUnderstanding common and unique mechanisms driving oncogenic processes in human tumors is indispensable to develop efficient therapies. Recent studies have proposed Twinfilin Actin Binding Protein 1 (TWF1) as a putative driver gene in lung cancer, pancreatic cancer and breast cancer, however a systematic pan-cancer analysis has not been carried out.MethodsHere, we set out to explore the role of TWF1 in 33 tumor types using TCGA (The Cancer Genome Atlas), GEO (Gene Expression Omnibus) dataset, Human Protein Atlas (HPA), and several bioinformatic tools.ResultsAs part of our analysis, we have assessed TWF1 expression across tumors. We found that over-expression of TWF1 generally predicted poor OS for patients with tumors with high TWF1 expression, such as mesothelioma, lung adenocarcinoma, cervical cancer and pancreatic adenocarcinoma. We also assessed the mutation burden of TWF1 in cancer and the TWF1-associated survival of cancer patients, compared the phosphorylation of TWF1 between normal and primary tumor tissues and explored putative functional mechanisms in TWF1-mediated oncogenesis.ConclusionsOur pan-cancer analysis provides a comprehensive overview of the oncogenic roles of TWF1 in multiple human cancers.

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