scholarly journals Depletion ofL-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes

Autophagy ◽  
2012 ◽  
Vol 8 (11) ◽  
pp. 1557-1576 ◽  
Author(s):  
Rósula García-Navas ◽  
Markus Munder ◽  
Faustino Mollinedo
Keyword(s):  
Endoplasmic Reticulum ◽  
T Lymphocytes ◽  
Endoplasmic Reticulum Stress ◽  
Human T Lymphocytes ◽  
Cytoprotective Response

Atrazine induces endoplasmic reticulum stress-mediated apoptosis of T lymphocytes via the caspase-8-dependent pathway

2015 ◽  
Vol 31 (8) ◽  
pp. 998-1008 ◽  
Author(s):  
Eun-Jin Lee ◽  
Youngsaeng Jang ◽  
Kwonyoon Kang ◽  
Da-Hyun Song ◽  
Rihyun Kim ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
T Lymphocytes ◽  
Endoplasmic Reticulum Stress ◽  
Caspase 8 ◽  
Dependent Pathway

scholarly journals Pancreatic cancer‐derived exosomes induce apoptosis of T lymphocytes through the p38 MAPK‐mediated endoplasmic reticulum stress

2020 ◽  
Vol 34 (6) ◽  
pp. 8442-8458 ◽  
Author(s):  
Tao Shen ◽  
Zihang Huang ◽  
Chengfei Shi ◽  
Xiaofan Pu ◽  
Xiaodong Xu ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Endoplasmic Reticulum ◽  
T Lymphocytes ◽  
Endoplasmic Reticulum Stress ◽  
P38 Mapk

scholarly journals 0313 : Microparticles from apoptotic T lymphocytes induce endothelial dysfunction through induction of endoplasmic reticulum stress

2015 ◽  
Vol 7 (2) ◽  
pp. 149-150
Author(s):  
Zainab Safiedeen ◽  
Isabel Rodriguez-Gomez ◽  
Raffaella Soleti ◽  
Dayannath Vaithilingam ◽  
Abdelali Agouni ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endothelial Dysfunction ◽  
T Lymphocytes ◽  
Endoplasmic Reticulum Stress

scholarly journals Estradiol-induced inhibition of endoplasmic reticulum stress normalizes splenic CD4 + T lymphocytes following hemorrhagic shock

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Peng Wang ◽  
Li-Na Jiang ◽  
Chen Wang ◽  
Ying Li ◽  
Meng Yin ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
T Lymphocytes ◽  
Endoplasmic Reticulum Stress ◽  
Hemorrhagic Shock ◽  
Cytokine Production ◽  
White Pulp ◽  
Beneficial Effects ◽  
17Β Estradiol ◽  
Activating Transcription Factor ◽  
Phenylbutyric Acid

AbstractThe aim is to investigate that 17β-estradiol (E2)/estrogen receptors (ERs) activation normalizes splenic CD4 + T lymphocytes proliferation and cytokine production through inhibition of endoplasmic reticulum stress (ERS) following hemorrhage. The results showed that hemorrhagic shock (hemorrhage through femoral artery, 38–42 mmHg for 90 min followed by resuscitation of 30 min and subsequent observation period of 180 min) decreased the CD4+ T lymphocytes proliferation and cytokine production after isolation and incubation with Concanavalin A (5 μg/mL) for 48 h, induced the splenic injury with evidences of missed contours of the white pulp, irregular cellular structure, and typical inflammatory cell infiltration, upregulated the expressions of ERS biomarkers 78 kDa glucose-regulated protein (GRP78) and activating transcription factor 6 (ATF6). Either E2, ER-α agonist propyl pyrazole triol (PPT) or ERS inhibitor 4-Phenylbutyric acid administration normalized these parameters, while ER-β agonist diarylpropionitrile administration had no effect. In contrast, administrations of either ERs antagonist ICI 182,780 or G15 abolished the salutary effects of E2. Likewise, ERS inducer tunicamycin induced an adverse effect similarly to that of hemorrhagic shock in sham rats, and aggravated shock-induced effects, also abolished the beneficial effects of E2 and PPT, respectively. Together, the data suggest that E2 produces salutary effects on CD4+ T lymphocytes function, and these effects are mediated by ER-α and GPR30, but not ER-β, and associated with the attenuation of hemorrhagic shock-induced ERS.

Abstract #403: The Glutathione Mimic Ebselen Inhibits Oxidative Stress but not Endoplasmic Reticulum Stress in Endothelial Cells.

2015 ◽  
Vol 21 ◽  
pp. 85-86
Author(s):  
William Kurban ◽  
Salma Makhoul Ahwach ◽  
Melanie Thomas ◽  
Luisa Onsteed-Haas ◽  
Michael Haas
Keyword(s):  
Oxidative Stress ◽  
Endothelial Cells ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress
Sign in / Sign up

Export Citation Format

Share Document