Atrazine induces endoplasmic reticulum stress-mediated apoptosis of T lymphocytes via the caspase-8-dependent pathway

2015 ◽  
Vol 31 (8) ◽  
pp. 998-1008 ◽  
Author(s):  
Eun-Jin Lee ◽  
Youngsaeng Jang ◽  
Kwonyoon Kang ◽  
Da-Hyun Song ◽  
Rihyun Kim ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
T Lymphocytes ◽  
Endoplasmic Reticulum Stress ◽  
Caspase 8 ◽  
Dependent Pathway

scholarly journals Cutting Edge: Endoplasmic Reticulum Stress Licenses Macrophages To Produce Mature IL-1β in Response to TLR4 Stimulation through a Caspase-8– and TRIF-Dependent Pathway

2014 ◽  
Vol 192 (5) ◽  
pp. 2029-2033 ◽  
Author(s):  
Kevin Shenderov ◽  
Nicolas Riteau ◽  
Ronald Yip ◽  
Katrin D. Mayer-Barber ◽  
Sandy Oland ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Cutting Edge ◽  
Caspase 8 ◽  
Dependent Pathway

Interaction between caspase-8 activation and endoplasmic reticulum stress in glycochenodeoxycholic acid-induced apoptotic HepG2 cells

Toxicology ◽  
2007 ◽  
Vol 241 (3) ◽  
pp. 146-156 ◽  
Author(s):  
Toru Iizaka ◽  
Mayumi Tsuji ◽  
Hideto Oyamada ◽  
Yuri Morio ◽  
Katsuji Oguchi
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Hepg2 Cells ◽  
Caspase 8

Kaempferol induced apoptosis via endoplasmic reticulum stress and mitochondria-dependent pathway in human osteosarcoma U-2 OS cells

2010 ◽  
Vol 54 (11) ◽  
pp. 1585-1595 ◽  
Author(s):  
Wen-Wen Huang ◽  
Yu-Jen Chiu ◽  
Ming-Jen Fan ◽  
Hsu-Feng Lu ◽  
Hsiu-Feng Yeh ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Human Osteosarcoma ◽  
Induced Apoptosis ◽  
Dependent Pathway

scholarly journals Shengmai Injection Improved Doxorubicin-Induced Cardiomyopathy by Alleviating Myocardial Endoplasmic Reticulum Stress and Caspase-12 Dependent Apoptosis

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Yu Chen ◽  
Yong Tang ◽  
Yin Xiang ◽  
Yu-Quan Xie ◽  
Xiao-Hong Huang ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Chinese Medicine ◽  
Endoplasmic Reticulum Stress ◽  
Er Stress ◽  
Heart Function ◽  
Shengmai Injection ◽  
Heart Damage ◽  
Myocardial Apoptosis ◽  
Caspase 12 ◽  
Dependent Pathway

Background.Apoptosis plays vital roles in the progression of doxorubicin-induced cardiomyopathy (DOX-CM). Endoplasmic reticulum stress (ER stress) could induce specific apoptosis by caspase-12 dependent pathway. Shengmai Injection (SMI), a famous Traditional Chinese Medicine, could alleviate the heart damage via inhibiting myocardial apoptosis. However, it is unknown whether SMI can alleviate ER stress and its specific apoptosis in the setting of DOX-CM.Objective.To explore the effects of SMI on heart function, myocardial ER stress, and apoptosis of DOX-CM rats.Methods.Rats with DOX-CM were treated by SMI. Heart function was assessed by echocardiography and brain natriuretic peptide. Myocardial apoptosis was detected by TUNEL assay. ER stress was assessed by detecting the expressions of GRP78 and caspase-12.Results.At the end of eight-week, compared to control, significant heart dysfunction happened in DOX group. The ratio of apoptotic cardiomyocytes and the expressions of GRP78 and caspase-12 increased significantly (P<0.05). Compared to DOX group, the apoptotic ratio and the expressions of GRP78 and caspase-12 significantly decreased in DOX + SMI group (P<0.05), accompanied with improved heart function.Conclusion.SMI could alleviate myocardial ER stress and caspase-12 dependent apoptosis, which subsequently helped to improve the heart function of rats with DOX-CM.

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