scholarly journals Changes in Steroid Concentrations with the Timing of Corticotropin Stimulation Testing in Participants with Adrenal Sufficiency

2012 ◽  
Vol 18 (1) ◽  
pp. 66-75 ◽  
Author(s):  
Jacqueline Jonklaas ◽  
Jennifer Holst ◽  
Joseph Verbalis ◽  
Marieta Pehlivanova ◽  
Steven Soldin
Keyword(s):  
Corticotropin Stimulation

scholarly journals Distribution of membrane cholesterol of adrenal cortical cells after corticotropin stimulation

1983 ◽  
Vol 214 (2) ◽  
pp. 561-567 ◽  
Author(s):  
O M Conneely ◽  
J M Greene ◽  
D R Headon ◽  
J Hsiao ◽  
F Ungar
Keyword(s):  
Plasma Membrane ◽  
Cholesteryl Ester ◽  
Membrane Cholesterol ◽  
Cortical Cells ◽  
Cholesterol Levels ◽  
Adrenal Cortical Cells ◽  
Hydrolysis Of ◽  
Plasma Membrane Cholesterol ◽  
Corticotropin Stimulation ◽  
Stimulation Of

Membrane cholesterol in adrenal cortical cells is enriched in the plasma membrane. Stimulation of isolated adrenal cortical cells with corticotropin leads to the production of corticosterone. At high levels of corticotropin, cholesterol for corticosterone synthesis arises by hydrolysis of cellular cholesteryl ester, whereas at lower levels of corticotropin cholesteryl ester levels are unchanged from control values and there is a decrease in plasma-membrane cholesterol levels.

Reproducibility of the Corticotropin Stimulation Test in Septic Shock

2006 ◽  
Vol 103 (4) ◽  
pp. 1057
Author(s):  
Pekka Loisa ◽  
Ari Uusaro ◽  
Esko Ruokonen
Keyword(s):  
Septic Shock ◽  
Stimulation Test ◽  
Corticotropin Stimulation

scholarly journals The Prevalence of Tertiary Adrenal Insufficiency in Patients Receiving Topical Glucocorticoid Treatment for Oral Lichen Planus

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A99-A99
Author(s):  
Margret J Einarsdottir ◽  
Maria Bankvall ◽  
Jairo Robledo-Sierra ◽  
Per-Olof Rödström ◽  
Penelope Trimpou ◽  
...  
Keyword(s):  
Adrenal Insufficiency ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Peak Level ◽  
Serum Cortisol ◽  
Clobetasol Propionate ◽  
Stimulation Test ◽  
Glucocorticoid Treatment ◽  
Oral Lichen ◽  
Corticotropin Stimulation

Abstract Objective: Glucocorticoid (GC) treatment suppress the hypothalamic-pituitary-adrenal axis, which may lead to tertiary adrenal insufficiency. This study aimed to investigate the prevalence of tertiary adrenal insufficiency among patients with oral lichen planus treated with topical GC (clobetasol propionate) in the oral cavity, a standard treatment option for this condition. Methods: In this cross-sectional study, we included 24 patients with oral lichen planus receiving long-term (> 6 weeks) clobetasol propionate treatment. Adrenal function was assessed by measuring serum cortisol between 8–9 AM, after a withdrawal of treatment for 48 hours. For patients with serum cortisol concentrations below 280 nmol/L (10 µg/dL), a 250 µg corticotropin stimulation test was performed. Results: Twenty patients had normal serum cortisol concentrations (range 280–621 nmol/L), whereas four patients had low serum cortisol concentrations (13, 45, 63, and 229 nmol/L, respectively). A corticotropin stimulation test revealed partial adrenal insufficiency in two patients (serum cortisol peak level 350 nmol/L and 360 nmol/L) and severe adrenal insufficiency in another two patients (serum cortisol peak level 150 nmol/L and 210 nmol/L). Conclusion: In this small study, approximately 20% of patients receiving chronic topical GCs treatment for oral lichen planus had tertiary adrenal insufficiency. It is essential to be aware of this potential risk and to inform patients about the need for GC stress-doses during an intercurrent illness episode.

scholarly journals The Caveats of Corticotropin Stimulation Test in Diagnosing Secondary Adrenal Insufficiency: Case Reports and Literature Review

2016 ◽  
Vol 6 (5) ◽  
pp. 154-157
Author(s):  
Ekaterina Manuylova ◽  
Laura M. Calvi ◽  
Catherine Hastings ◽  
G. Edward Vates ◽  
Maryanne Stahlecker-Etter ◽  
...  
Keyword(s):  
Literature Review ◽  
Adrenal Insufficiency ◽  
Case Reports ◽  
Stimulation Test ◽  
Secondary Adrenal Insufficiency ◽  
Corticotropin Stimulation

Cortisol Response to Corticotropin Stimulation in Trauma Patients

2002 ◽  
Vol 97 (4) ◽  
pp. 807-813 ◽  
Author(s):  
Sophie Hoen ◽  
Karim Asehnoune ◽  
Sylvie Brailly-Tabard ◽  
Jean-Xavier Mazoit ◽  
Dan Benhamou ◽  
...  
Keyword(s):  
Hemorrhagic Shock ◽  
Interleukin 6 ◽  
Early Phase ◽  
Injury Severity ◽  
Late Phase ◽  
Early Response ◽  
Adrenocortical Function ◽  
Trauma Patients ◽  
Cortisol Response ◽  
Corticotropin Stimulation

Background An abnormal adrenocortical function and a vasopressor dependency have been demonstrated during septic shock. Because trauma and hemorrhage are the leading causes of noninfectious inflammatory syndromes, the goal of this study was to assess the adrenal reserve of trauma patients and its relation with clinical course. Methods Cortisol response to an intravenous corticotropin bolus was obtained in 34 young trauma patients (Injury Severity Score =29.1 +/- 7.3) at the end of the resuscitative period ("early phase") and at the end of the first posttraumatic week ("late period"). Cortisol response less than +9 g/dl defined an impaired adrenal function, and the corresponding patient was called a nonresponder. According to the early response, hemorrhagic shock, circulating interleukin-6, need for vasopressor therapy, subsequent organ dysfunction and infection, and outcomes were studied. Results Sixteen patients (47%) were nonresponders at the end of the early phase. Hemorrhagic shock was more frequent (69 vs. 28%; = 0.037) and interleukin-6 concentrations were higher (728 +/- 589 vs. 311 +/- 466 pg/ml; = 0.048) in these patients. The early cortisol responses were negatively correlated with the concomitant interleukin-6 serum concentrations (r(2) = 0.298; = 0.003). Four early nonresponders (and shock patients) remained nonresponders during the late phase (25%). Morbidity and mortality were similar in early nonresponders and responders. The duration of norepinephrine treatment and the total amount of infused drug were significantly higher in early nonresponders. Conclusions A sustained impairment of adrenal reserve is frequently observed in trauma patients. This abnormal cortisol response to corticotropin stimulation is related with the inflammatory consequences of hemorrhagic shock and is followed by a prolonged vasopressor dependency.

scholarly journals Salivary Cortisol and Cortisone After Low-Dose Corticotropin Stimulation in the Diagnosis of Adrenal Insufficiency

2017 ◽  
Vol 1 (2) ◽  
pp. 96-108 ◽  
Author(s):  
Ingrid Yin Fung Mak ◽  
Benjamin Yick Toa Au Yeung ◽  
Ying Wai Ng ◽  
Cheung Hei Choi ◽  
Heidi Yan Ping Iu ◽  
...  
Keyword(s):  
Adrenal Insufficiency ◽  
Salivary Cortisol ◽  
Low Dose ◽  
Corticotropin Stimulation
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