Effect of Vitamin D Therapy on Bone Turnover Markers in Postmenopausal Women with Osteoporosis and Osteopenia

2011 ◽  
Vol 17 (6) ◽  
pp. 873-879 ◽  
Author(s):  
Margaret Tanzy ◽  
Pauline Camacho
Keyword(s):  
Vitamin D ◽  
Bone Turnover ◽  
Postmenopausal Women ◽  
Bone Turnover Markers ◽  
Turnover Markers

scholarly journals Vitamin D Metabolites and Sex Steroid Indices in Postmenopausal Women with and without Low Bone Mass

Metabolites ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 86
Author(s):  
Nasser M. Al-Daghri ◽  
Sobhy M. Yakout ◽  
Mohammed G.A. Ansari ◽  
Syed D. Hussain ◽  
Kaiser A. Wani ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Turnover ◽  
Postmenopausal Women ◽  
Sex Hormones ◽  
Bone Turnover Markers ◽  
Vitamin D Metabolites ◽  
Mineral Density ◽  
Skeletal Health ◽  
Normal Bone Mineral Density ◽  
Turnover Markers

While the independent roles of vitamin D and sex hormones in skeletal health are well established, the associations of vitamin D and its metabolites to sex hormones and their indices are less investigated. In this observational study, clinical information of 189 Saudi postmenopausal women aged ≥50 years old [N = 80 with normal bone mineral density (BMD), aged 53.3 ± 7.7 years with body mass index (BMI)= 34.1kg/m2 ± 5.8, and N = 109 with low BMD (T-score −1.0 to −2.5), aged 57.0 ± 8.2 years, BMI = 32.4kg/m2 ± 6.2] was extracted from an existing capital-wide osteoporosis registry in Riyadh, Saudi Arabia. Data included were BMD scores, serum total 25(OH)D, sex hormones, and bone turnover markers which were measured using commercially available assays. Age- and BMI-adjusted comparisons revealed significantly higher parathyroid hormone (PTH) levels as well as significantly lower testosterone and bioavailable testosterone in the low BMD group than the normal BMD group (p-values 0.04, 0.02, and 0.03, respectively). Stepwise linear regression showed that circulating testosterone levels accounted for 9.7% and 8.9% of the variances perceived in bioavailable 25(OH)D and free 25(OH)D, respectively (p < 0.01), independent of other sex hormones, sex hormone indices, and bone turnover markers. Our study suggests that androgens are significantly associated with non-conventional vitamin D metabolites and these associations may have clinical relevance in assessing risk for low BMD and osteoporosis in Arab postmenopausal women.

scholarly journals Influence of Vitamin D Status on the Effect of Statins on Bone Mineral Density and Bone Turnover Markers in Postmenopausal Women

2014 ◽  
Vol 99 (9) ◽  
pp. 3304-3309 ◽  
Author(s):  
José L. Hernández ◽  
José M. Olmos ◽  
Galo Romaña ◽  
Javier Llorca ◽  
Josefina Martínez ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Turnover ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Vitamin D Status ◽  
Mineral Density ◽  
Turnover Markers

scholarly journals Serum 25-OH Vitamin D in relation to Bone Mineral Density and Bone Turnover

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Nicola Napoli ◽  
Rocky Strollo ◽  
Delia Sprini ◽  
Ernesto Maddaloni ◽  
Giovam Battista Rini ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Femoral Neck ◽  
Bone Turnover ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Mineral Density ◽  
Serum 25Ohd ◽  
Turnover Markers

It is unclear which vitamin D status is optimal for bone health. In this study, we aimed to assess cutoffs of 25-hydroxyvitamin D (25OHD) derived by the literature (20, 25, or 30 ng/mL) in relation to bone turnover and bone mineral density (BMD). Serum 25OHD, PTH, osteocalcin, bone alkaline phosphatase, and C-telopeptide were measured in 274 consecutive postmenopausal women. BMD of the lumbar spine (L1–L4) and of femoral neck were also evaluated. 50 patients had normal BMD, while 124 had osteopenia and 100 had osteoporosis. 37.6%, 56.2%, and 70.8% subjects had serum 25OHD lower than 20, 25, or 30 ng/mL, respectively. No differences in bone turnover markers were found when comparing patients with low 25OHD defined according to the different cutoffs. However, a cutoff of 25 ng/mL appeared to differentiate better than a cutoff of 30 ng/mL in those subjects with reduced femoral neck BMD. The PTH plateau occurred at 25OHD levels of 26–30 ng/mL. In conclusion, vitamin D deficiency is common in Sicilian postmenopausal women and it may be associated with low BMD and increased bone turnover markers. Further studies are needed to better define the right cutoff for normal vitamin D levels in postmenopausal women.

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