Weekly alendronate plus vitamin D3 5600 IU vs. standard care: Effect on serum 25(OH) vitamin D, bone turnover markers, and BMD in osteoporotic postmenopausal women with vitamin D inadequacy — 1-year results of a randomized trial

Bone ◽  
2011 ◽  
Vol 48 ◽  
pp. S218
Author(s):  
D.P. Kiel ◽  
N. Binkley ◽  
S. Boonen ◽  
S. Ralston ◽  
J.-Y. Regnister ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Turnover ◽  
Randomized Trial ◽  
Postmenopausal Women ◽  
Vitamin D3 ◽  
Bone Turnover Markers ◽  
Standard Care ◽  
Turnover Markers ◽  
25 Oh Vitamin D

Randomized Trial of Alendronate Plus Vitamin D3 Versus Standard Care in Osteoporotic Postmenopausal Women with Vitamin D Insufficiency

2011 ◽  
Vol 88 (6) ◽  
pp. 485-494 ◽  
Author(s):  
Stuart H. Ralston ◽  
◽  
Neil Binkley ◽  
Steven Boonen ◽  
Douglas P. Kiel ◽  
...  
Keyword(s):  
Vitamin D ◽  
Randomized Trial ◽  
Postmenopausal Women ◽  
Vitamin D3 ◽  
Standard Care ◽  
Vitamin D Insufficiency

scholarly journals Vitamin D Metabolites and Sex Steroid Indices in Postmenopausal Women with and without Low Bone Mass

Metabolites ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 86
Author(s):  
Nasser M. Al-Daghri ◽  
Sobhy M. Yakout ◽  
Mohammed G.A. Ansari ◽  
Syed D. Hussain ◽  
Kaiser A. Wani ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Turnover ◽  
Postmenopausal Women ◽  
Sex Hormones ◽  
Bone Turnover Markers ◽  
Vitamin D Metabolites ◽  
Mineral Density ◽  
Skeletal Health ◽  
Normal Bone Mineral Density ◽  
Turnover Markers

While the independent roles of vitamin D and sex hormones in skeletal health are well established, the associations of vitamin D and its metabolites to sex hormones and their indices are less investigated. In this observational study, clinical information of 189 Saudi postmenopausal women aged ≥50 years old [N = 80 with normal bone mineral density (BMD), aged 53.3 ± 7.7 years with body mass index (BMI)= 34.1kg/m2 ± 5.8, and N = 109 with low BMD (T-score −1.0 to −2.5), aged 57.0 ± 8.2 years, BMI = 32.4kg/m2 ± 6.2] was extracted from an existing capital-wide osteoporosis registry in Riyadh, Saudi Arabia. Data included were BMD scores, serum total 25(OH)D, sex hormones, and bone turnover markers which were measured using commercially available assays. Age- and BMI-adjusted comparisons revealed significantly higher parathyroid hormone (PTH) levels as well as significantly lower testosterone and bioavailable testosterone in the low BMD group than the normal BMD group (p-values 0.04, 0.02, and 0.03, respectively). Stepwise linear regression showed that circulating testosterone levels accounted for 9.7% and 8.9% of the variances perceived in bioavailable 25(OH)D and free 25(OH)D, respectively (p < 0.01), independent of other sex hormones, sex hormone indices, and bone turnover markers. Our study suggests that androgens are significantly associated with non-conventional vitamin D metabolites and these associations may have clinical relevance in assessing risk for low BMD and osteoporosis in Arab postmenopausal women.

scholarly journals Influence of Vitamin D Status on the Effect of Statins on Bone Mineral Density and Bone Turnover Markers in Postmenopausal Women

2014 ◽  
Vol 99 (9) ◽  
pp. 3304-3309 ◽  
Author(s):  
José L. Hernández ◽  
José M. Olmos ◽  
Galo Romaña ◽  
Javier Llorca ◽  
Josefina Martínez ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Turnover ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Vitamin D Status ◽  
Mineral Density ◽  
Turnover Markers
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