ROLE OF EYE MUSCLE ANTIBODY MEASUREMENT IN DIAGNOSIS OF THYROID-ASSOCIATED OPHTHALMOPATHY: A LABORATORY UPDATE

1998 ◽  
Vol 4 (3) ◽  
pp. 127-132 ◽  
Author(s):  
Sumihisa Kubota, MD ◽  
Kazuaki Gunji, MD ◽  
Carol Stolarski, BS ◽  
John S. Kennerdell, MD ◽  
Jack R. Wall, MD, PhD
Keyword(s):  
Eye Muscle ◽  
Thyroid Associated Ophthalmopathy

scholarly journals Extraocular Muscles Tension, Tonus, and Proprioception in Infantile Strabismus: Role of the Oculomotor System in the Pathogenesis of Infantile Strabismus—Review of the Literature

Scientifica ◽  
2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Costantino Schiavi
Keyword(s):  
Critical Period ◽  
Muscle Force ◽  
Sensory System ◽  
Oculomotor System ◽  
Extraocular Muscles ◽  
Review Of The Literature ◽  
Eye Muscle ◽  
System A ◽  
Concomitant Strabismus

The role played by the extraocular muscles (EOMs) in the etiology of concomitant infantile strabismus is still debated and it has not yet definitively established if the sensory anomalies in concomitant strabismus are a consequence or a primary cause of the deviation. The commonest theory supposes that most strabismus results from abnormal innervation of the EOMs, but the cause of this dysfunction and its origin, whether central or peripheral, are still unknown. The interaction between sensory factors and innervational factors, that is, esotonus, accommodation, convergence, divergence, and vestibular reflexes in visually immature infants with family predisposition, is suspected to create conditions that prevent binocular alignment from stabilizing and strengthening. Some role in the onset of fixation instability and infantile strabismus could be played by the feedback control of eye movements and by dysfunction of eye muscle proprioception during the critical period of development of the visual sensory system. A possible role in the onset, maintenance, or worsening of the deviation of abnormalities of muscle force which have their clinical equivalent in eye muscle overaction and underaction has been investigated under either isometric or isotonic conditions, and in essence no significant anomalies of muscle force have been found in concomitant strabismus.

Role of Cytokines in the Pathogenesis of Thyroid-Associated Ophthalmopathy

Thyroid ◽  
2002 ◽  
Vol 12 (3) ◽  
pp. 217-221 ◽  
Author(s):  
Yuji Hiromatsu ◽  
Hiroo Kaku ◽  
Ikuyo Miyake ◽  
Shiro Murayama ◽  
Eri Soejima
Keyword(s):  
Thyroid Associated Ophthalmopathy

Antibodies to orbital tissues in thyroid-associated ophthalmopathy

1992 ◽  
Vol 126 (2) ◽  
pp. 137-142 ◽  
Author(s):  
Petros Perros ◽  
Pat Kendall-Taylor
Keyword(s):  
Autoimmune Diseases ◽  
Extraocular Muscle ◽  
Enzyme Linked Immunosorbent Assay ◽  
Eye Muscle ◽  
Autoimmune Attack ◽  
Thyroid Associated Ophthalmopathy ◽  
Binding Antibody ◽  
Antibody Levels ◽  
Orbital Fibroblasts ◽  
Normal Controls

Thyroid-associated ophthalmopathy is thought to be an autoimmune disease affecting the orbit. The precise pathogenetic mechanisms are not known, but extraocular muscle and/or orbital fibroblasts are the likely targets of the autoimmune attack. Sera from 41 normal controls, 79 patients with thyroid-associated ophthalmopathy and 72 patients with other autoimmune diseases were examined for antibodies to cultured orbital fibroblasts and extraocular muscle by enzyme-linked immunosorbent assay. Orbital fibroblast antibody levels varied widely in all subject groups studied, and failed to distinguish patients with thyroid-associated ophthalmopathy from patients with other autoimmune diseases or controls. Eye-muscle binding antibody levels were higher amongst patients with ophthalmopathy compared to normal controls and patients with Graves' hyperthyroidism without clinical evidence of ophthalmopathy. Furthermore, eye-muscle binding antibody levels were found to be particularly high in patients with ophthalmopathy and concurrent dermopathy, and in patients with ophthalmic (euthyroid) Graves' disease.

Eye Muscle Antibodies and Subtype of Thyroid-Associated Ophthalmopathy

Thyroid ◽  
2002 ◽  
Vol 12 (3) ◽  
pp. 187-191 ◽  
Author(s):  
Matthias Kaspar ◽  
Curtis Archibald ◽  
Anna Maria De Bellis ◽  
Audrey Wu Li ◽  
Masayo Yamada ◽  
...  
Keyword(s):  
Eye Muscle ◽  
Thyroid Associated Ophthalmopathy
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