scholarly journals Advances in HIV microbicide development

2011 ◽  
Vol 3 (16) ◽  
pp. 2101-2116 ◽  
Author(s):  
Joanna S Olsen ◽  
David Easterhoff ◽  
Stephen Dewhurst
Keyword(s):  
Microbicide Development ◽  
Hiv Microbicide

Expression, purification, and characterization of recombinant cyanovirin-N for vaginal anti-HIV microbicide development

2005 ◽  
Vol 39 (2) ◽  
pp. 229-236 ◽  
Author(s):  
Diana M. Colleluori ◽  
Deborah Tien ◽  
Feirong Kang ◽  
Tara Pagliei ◽  
Ryan Kuss ◽  
...  
Keyword(s):  
Purification And Characterization ◽  
Microbicide Development ◽  
Hiv Microbicide ◽  
Anti Hiv

Nanoparticles-in-film for the combined vaginal delivery of anti-HIV microbicide drugs

2016 ◽  
Vol 243 ◽  
pp. 43-53 ◽  
Author(s):  
Cassilda Cunha-Reis ◽  
Alexandra Machado ◽  
Luísa Barreiros ◽  
Francisca Araújo ◽  
Rute Nunes ◽  
...  
Keyword(s):  
Vaginal Delivery ◽  
Hiv Microbicide ◽  
Anti Hiv

Current State of Microbicide Development

2018 ◽  
Vol 104 (6) ◽  
pp. 1074-1081 ◽  
Author(s):  
Yannick L. Traore ◽  
Yufei Chen ◽  
Emmanuel A. Ho
Keyword(s):  
Current State ◽  
Microbicide Development

Spray-Dried Thiolated Chitosan-Coated Sodium Alginate Multilayer Microparticles for Vaginal HIV Microbicide Delivery

2017 ◽  
Vol 19 (3) ◽  
pp. 692-702 ◽  
Author(s):  
Jianing Meng ◽  
Vivek Agrahari ◽  
Miezan J. Ezoulin ◽  
Sudhaunshu S. Purohit ◽  
Tao Zhang ◽  
...  
Keyword(s):  
Sodium Alginate ◽  
Thiolated Chitosan ◽  
Hiv Microbicide ◽  
Spray Dried

scholarly journals Effects of gel volume on pharmacokinetics for vaginal and rectal applications of combination DuoGel-IQB4012, a dual chamber-dual drug HIV microbicide gel, in pigtailed macaques

2018 ◽  
Vol 8 (5) ◽  
pp. 1180-1190 ◽  
Author(s):  
Lara E. Pereira ◽  
Tyana Singletary ◽  
Amy Martin ◽  
Chuong T. Dinh ◽  
Frank Deyounks ◽  
...  
Keyword(s):  
Dual Chamber ◽  
Hiv Microbicide ◽  
Dual Drug

Lactoferrin nanoparticles coencapsulated with curcumin and tenofovir improve vaginal defense against HIV-1 infection

Nanomedicine ◽  
2021 ◽  
Author(s):  
Samrajya Lakshmi Yeruva ◽  
Prashant Kumar ◽  
Seetharam Deepa ◽  
Anand K Kondapi
Keyword(s):  
Physicochemical Characterization ◽  
Systemic Circulation ◽  
Application Site ◽  
Drug Nanoparticles ◽  
In Vivo Experiments ◽  
Hiv Microbicide ◽  
Anti Hiv ◽  
Hiv 1

Aim: We report here the development of tenofovir- and curcumin-loaded lactoferrin nanoparticles (TCNPs) as an HIV-microbicide. Materials & methods: TCNPs were subjected to various physicochemical characterization experiments, followed by in vitro and in vivo experiments to assess their efficacy. Results: TCNPs had a diameter of 74.31 ± 2.56 nm with a gross encapsulation of more than 61% for each drug. Nanoparticles were effective against HIV-1 replication, with an IC50 of 1.75 μM for curcumin and 2.8 μM for tenofovir. TCNPs provided drug release at the application site for up to 8–12 h, with minimal leakage into the systemic circulation. TCNPs showed spermicidal activity at ≥200 μM and induced minimal cytotoxicity and inflammation in the vaginal epithelium as revealed by histopathological and ELISA studies. Conclusion: We demonstrated that TCNPs could serve as a novel anti-HIV microbicidal agent in rats. [Formula: see text]

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