Anti-HIV microbicide development: targeting the virus is the key

2011 ◽  
Vol 6 (5) ◽  
pp. 553-556 ◽  
Author(s):  
Barry R O’Keefe
Keyword(s):  
Microbicide Development ◽  
Hiv Microbicide ◽  
Anti Hiv

Expression, purification, and characterization of recombinant cyanovirin-N for vaginal anti-HIV microbicide development

2005 ◽  
Vol 39 (2) ◽  
pp. 229-236 ◽  
Author(s):  
Diana M. Colleluori ◽  
Deborah Tien ◽  
Feirong Kang ◽  
Tara Pagliei ◽  
Ryan Kuss ◽  
...  
Keyword(s):  
Purification And Characterization ◽  
Microbicide Development ◽  
Hiv Microbicide ◽  
Anti Hiv

Nanoparticles-in-film for the combined vaginal delivery of anti-HIV microbicide drugs

2016 ◽  
Vol 243 ◽  
pp. 43-53 ◽  
Author(s):  
Cassilda Cunha-Reis ◽  
Alexandra Machado ◽  
Luísa Barreiros ◽  
Francisca Araújo ◽  
Rute Nunes ◽  
...  
Keyword(s):  
Vaginal Delivery ◽  
Hiv Microbicide ◽  
Anti Hiv

Lactoferrin nanoparticles coencapsulated with curcumin and tenofovir improve vaginal defense against HIV-1 infection

Nanomedicine ◽  
2021 ◽  
Author(s):  
Samrajya Lakshmi Yeruva ◽  
Prashant Kumar ◽  
Seetharam Deepa ◽  
Anand K Kondapi
Keyword(s):  
Physicochemical Characterization ◽  
Systemic Circulation ◽  
Application Site ◽  
Drug Nanoparticles ◽  
In Vivo Experiments ◽  
Hiv Microbicide ◽  
Anti Hiv ◽  
Hiv 1

Aim: We report here the development of tenofovir- and curcumin-loaded lactoferrin nanoparticles (TCNPs) as an HIV-microbicide. Materials & methods: TCNPs were subjected to various physicochemical characterization experiments, followed by in vitro and in vivo experiments to assess their efficacy. Results: TCNPs had a diameter of 74.31 ± 2.56 nm with a gross encapsulation of more than 61% for each drug. Nanoparticles were effective against HIV-1 replication, with an IC50 of 1.75 μM for curcumin and 2.8 μM for tenofovir. TCNPs provided drug release at the application site for up to 8–12 h, with minimal leakage into the systemic circulation. TCNPs showed spermicidal activity at ≥200 μM and induced minimal cytotoxicity and inflammation in the vaginal epithelium as revealed by histopathological and ELISA studies. Conclusion: We demonstrated that TCNPs could serve as a novel anti-HIV microbicidal agent in rats. [Formula: see text]

scholarly journals Advances in HIV microbicide development

2011 ◽  
Vol 3 (16) ◽  
pp. 2101-2116 ◽  
Author(s):  
Joanna S Olsen ◽  
David Easterhoff ◽  
Stephen Dewhurst
Keyword(s):  
Microbicide Development ◽  
Hiv Microbicide

scholarly journals The Anti-HIV Microbicide Candidate RC-101 Inhibits Pathogenic Vaginal Bacteria Without Harming Endogenous Flora or Mucosa

2012 ◽  
Vol 69 (2) ◽  
pp. 150-158 ◽  
Author(s):  
Colleen R. Eade ◽  
Amy L. Cole ◽  
Camila Diaz ◽  
Lisa C. Rohan ◽  
Michael A. Parniak ◽  
...  
Keyword(s):  
Hiv Microbicide ◽  
Anti Hiv ◽  
Microbicide Candidate

scholarly journals The Future of HIV Prevention: Prospects for an Effective Anti-HIV Microbicide

2007 ◽  
Vol 21 (1) ◽  
pp. 219-239 ◽  
Author(s):  
Jeremy Nuttall ◽  
Joseph Romano ◽  
Karen Douville ◽  
Caroline Galbreath ◽  
Annaléne Nel ◽  
...  
Keyword(s):  
Hiv Prevention ◽  
The Future ◽  
Hiv Microbicide ◽  
Anti Hiv

scholarly journals An anti-HIV microbicide comes alive

2005 ◽  
Vol 102 (35) ◽  
pp. 12294-12295 ◽  
Author(s):  
L. A. Lagenaur ◽  
E. A. Berger
Keyword(s):  
Hiv Microbicide ◽  
Anti Hiv
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