scholarly journals Secondary glaucoma in small versus large uveal melanoma patients treated with stereotactic radiosurgery on linear accelerator

2019 ◽  
Vol 120 (12) ◽  
pp. 945-949
Author(s):  
J. Sekac ◽  
S. L. Ferkova ◽  
A. Kollarova ◽  
P. Kusenda ◽  
R. Furda ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Uveal Melanoma ◽  
Linear Accelerator ◽  
Secondary Glaucoma ◽  
Melanoma Patients

scholarly journals Enucleation After Stereotactic Radiosurgery in Patients With Uveal Melanoma

2020 ◽  
Vol 76 (1) ◽  
pp. 46-51
Author(s):  
Pavlína Zahorjanová ◽  
Ján Sekáč ◽  
Pavel Babál ◽  
Michal Štubňa
Keyword(s):  
Tumor Progression ◽  
Stereotactic Radiosurgery ◽  
Uveal Melanoma ◽  
Linear Accelerator ◽  
Slovak Republic ◽  
Neovascular Glaucoma ◽  
Treatment Modalities ◽  
Histopathological Findings ◽  
Randomised Study ◽  
Time Period

Introduction: In the past enucleation was the treatment of choice for all the patients with uveal melanoma. Nowadays, we prefer glope-sparing treatment modalities, except for large tumors, tumors with extrascleral extension and painful blind eyes. Most of the patients perform radiotherapy or local resection techniques. In Slovak Republic, the only one possibility is a stereotactic radiotherapy on a linear accelerator LINAC. Nevertheless, enucleation after radiotherapy is necessary for some patients. The causes are postradiation complications, mainly neovascular glaucoma, tumor recurrence, tumor progression or patient´s decision. Material and methods: The retrospective non-randomised study of 168 eyes of the patients with choroidal or ciliary body melanoma, who performed one-day session stereotactic radiosurgery at the linear accelerator LINAC during period 2007-2016. The data about postradiation complications were analysed based on the medical records of the patients and the data about enucleated eyes based on the histopathological findings. Results: The occurence of enucleation after radiotherapy in our cohort was 17 % (28 patients), with median time period after radiotherapy 21,5 months. The most common cause was neovascular glaucoma (82 %), then tumor progression (14 %) and patient´s decision (4 %). The most common histopathological finding was spindle-cell melanoma. Discussion: Others authors describe similar enucleation rate and causes. The histopathological findings indentified more viable melanoma cells in eyes enucleated for tumor progression in comparison with enucleation for other causes. Enucleation may be more difficult and the occurence of postoperative complications can be higher in the eyes after radiotherapy rather than primary enucleation. Conclusion: The management of the patients with uveal melanoma is difficult, and requires the cooperation of ophthalmologist, oncologist, radiation physicist and pathologist. Even if we make effort to preserve the eye, enucleation after radiotherapy is necessary in some patients.

scholarly journals 3D Printing Planning Stereotactic Radiosurgery in Uveal Melanoma Patients

3D Printing ◽  
2018 ◽  
Author(s):  
Alena Furdova ◽  
Adriana Furdova ◽  
Miron Sramka ◽  
Robert Furda ◽  
Gabriel Kralik
Keyword(s):  
3D Printing ◽  
Stereotactic Radiosurgery ◽  
Uveal Melanoma ◽  
Melanoma Patients

Functional stereotactic radiosurgery involving a dedicated linear accelerator and gamma unit: a comparison study

2004 ◽  
pp. 373-380 ◽  
Author(s):  
Timothy D. Solberg ◽  
Steven J. Goetsch ◽  
Michael T. Selch ◽  
William Melega ◽  
Goran Lacan ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Linear Accelerator ◽  
Treatment Plan ◽  
Single Shot ◽  
Submillimeter Range ◽  
Primate Model ◽  
Content Type ◽  
Stereotactic Frame ◽  
Targeting Ability ◽  
Fine Print

Object. The purpose of this work was to investigate the targeting and dosimetric characteristics of a linear accelerator (LINAC) system dedicated for stereotactic radiosurgery compared with those of a commercial gamma knife (GK) unit. Methods. A phantom was rigidly affixed within a Leksell stereotactic frame and axial computerized tomography scans were obtained using an appropriate stereotactic localization device. Treatment plans were performed, film was inserted into a recessed area, and the phantom was positioned and treated according to each treatment plan. In the case of the LINAC system, four 140° arcs, spanning ± 60° of couch rotation, were used. In the case of the GK unit, all 201 sources were left unplugged. Radiation was delivered using 3- and 8-mm LINAC collimators and 4- and 8-mm collimators of the GK unit. Targeting ability was investigated independently on the dedicated LINAC by using a primate model. Measured 50% spot widths for multisource, single-shot radiation exceeded nominal values in all cases by 38 to 70% for the GK unit and 11 to 33% for the LINAC system. Measured offsets were indicative of submillimeter targeting precision on both devices. In primate studies, the appearance of an magnetic resonance imaging—enhancing lesion coincided with the intended target. Conclusions. Radiosurgery performed using the 3-mm collimator of the dedicated LINAC exhibited characteristics that compared favorably with those of a dedicated GK unit. Overall targeting accuracy in the submillimeter range can be achieved, and dose distributions with sharp falloff can be expected for both devices.

scholarly journals Evaluation of the modified immune prognostic index to prognosticate outcomes in metastatic uveal melanoma patients treated with immune checkpoint inhibitors

2021 ◽  
Vol 10 (8) ◽  
pp. 2618-2626
Author(s):  
Michael S. Sander ◽  
Igor Stukalin ◽  
Isabelle A. Vallerand ◽  
Siddhartha Goutam ◽  
Benjamin W. Ewanchuk ◽  
...  
Keyword(s):  
Uveal Melanoma ◽  
Immune Checkpoint ◽  
Immune Checkpoint Inhibitors ◽  
Checkpoint Inhibitors ◽  
Prognostic Index ◽  
Melanoma Patients

Management of choroidal melanomas with linear accelerator-based stereotactic radiosurgery

1999 ◽  
Vol 77 (1) ◽  
pp. 62-65 ◽  
Author(s):  
Stephen Wan Leung ◽  
Ching-Yeh Hsiung ◽  
Hui-Chun Chen ◽  
Han-Jung Chen ◽  
Sue-Ann Lin
Keyword(s):  
Stereotactic Radiosurgery ◽  
Linear Accelerator ◽  
Choroidal Melanomas

Cutaneous dysplastic naevi in uveal melanoma patients: markers for prognosis?

2000 ◽  
Vol 10 (1) ◽  
pp. 36-39 ◽  
Author(s):  
E. Tóth-Molnár ◽  
H. Hammer ◽  
J. Oláh
Keyword(s):  
Uveal Melanoma ◽  
Melanoma Patients
Sign in / Sign up

Export Citation Format

Share Document