Current understanding and therapeutic approaches to combined hyperlipidemia with low HDL

2011 ◽  
Author(s):  
Ernst J. Schaefer ◽  
Raul D. Santos ◽  
Mariko Tani ◽  
Peter M. Schaefer ◽  
Bela F. Asztalos ◽  
...  
Keyword(s):  
Current Understanding ◽  
Therapeutic Approaches ◽  
Low Hdl

scholarly journals Mutant calreticulin in myeloproliferative neoplasms

Blood ◽  
2019 ◽  
Vol 134 (25) ◽  
pp. 2242-2248 ◽  
Author(s):  
Joan How ◽  
Gabriela S. Hobbs ◽  
Ann Mullally
Keyword(s):  
Myeloproliferative Neoplasms ◽  
Current Understanding ◽  
Clinical Implications ◽  
Therapeutic Approaches

In a Blood Spotlight that is also this month’s CME article, the authors review the current understanding of the biology underpinning mutant CALR-driven myeloproliferative neoplasms, discuss its clinical implications, and highlight future therapeutic approaches.

scholarly journals Current understanding of Age-related macular degeneration

2020 ◽  
Vol 3 (2) ◽  
Author(s):  
Swathi Kanduri ◽  
Monica Liliana Acosta ◽  
Trevor Sherwin ◽  
Charles Ninian John McGhee ◽  
Colin R Green
Keyword(s):  
Macular Degeneration ◽  
Elderly Population ◽  
The Elderly ◽  
Developed Countries ◽  
Age Related Macular Degeneration ◽  
Current Understanding ◽  
Therapeutic Approaches ◽  
Age Related ◽  
The Developed Countries ◽  
Irreversible Blindness

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly population 50 years of age or older in the developed countries. This review discusses the traditional clinical and histopathological presentation of AMD, epidemiology and genetics component in relation to the current understanding of the vascular nature of the disease. Therapeutic approaches to treat the disease are also included in the review.

scholarly journals Introduction to a review series on pathophysiology and treatment of acute GVHD

Blood ◽  
2020 ◽  
Vol 136 (4) ◽  
pp. 375-376
Author(s):  
Robert Zeiser
Keyword(s):  
Small Molecule ◽  
Graft Versus Host Disease ◽  
Acute Gvhd ◽  
Small Molecule Inhibitors ◽  
Associate Editor ◽  
Current Understanding ◽  
Therapeutic Approaches ◽  
Graft Versus Host ◽  
Acute Graft

Edited by Associate Editor Robert Zeiser, this Review Series presents the current understanding of the pathophysiology of and therapeutic approaches to acute graft-versus-host disease (aGVHD). The articles discuss the role of the microbiome in contributing to aGVHD and review how novel cellular therapies, biologicals, and small-molecule inhibitors may advance its treatment.

scholarly journals Current understanding of the role of Epstein–Barr virus in lymphomagenesis and therapeutic approaches to EBV-associated lymphomas

2008 ◽  
Vol 49 (sup1) ◽  
pp. 27-34 ◽  
Author(s):  
Jeffrey I. Cohen ◽  
Catherine M. Bollard ◽  
Rajiv Khanna ◽  
Stefania Pittaluga
Keyword(s):  
Epstein Barr Virus ◽  
Current Understanding ◽  
Therapeutic Approaches ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Arteriovenous Malformations—Current Understanding of the Pathogenesis with Implications for Treatment

2021 ◽  
Vol 22 (16) ◽  
pp. 9037
Author(s):  
Katharina Schimmel ◽  
Md Khadem Ali ◽  
Serena Y. Tan ◽  
Joyce Teng ◽  
Huy M. Do ◽  
...  
Keyword(s):  
Arteriovenous Malformations ◽  
Vascular Anomaly ◽  
Therapeutic Strategies ◽  
Clinical Findings ◽  
High Flow ◽  
Current Understanding ◽  
Significant Morbidity ◽  
Therapeutic Approaches ◽  
Research Gaps ◽  
Successful Development

Arteriovenous malformations are a vascular anomaly typically present at birth, characterized by an abnormal connection between an artery and a vein (bypassing the capillaries). These high flow lesions can vary in size and location. Therapeutic approaches are limited, and AVMs can cause significant morbidity and mortality. Here, we describe our current understanding of the pathogenesis of arteriovenous malformations based on preclinical and clinical findings. We discuss past and present accomplishments and challenges in the field and identify research gaps that need to be filled for the successful development of therapeutic strategies in the future.

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