scholarly journals Anti-cancer Effects of a Novel Quinoline Derivative 83b1 on Human Esophageal Squamous Cell Carcinoma through Down-Regulation of COX-2 mRNA and PGE2

2017 ◽  
Vol 49 (1) ◽  
pp. 219-229 ◽  
Author(s):  
Ivan Ho Yuen Pun ◽  
Dessy Chan ◽  
Sau Hing Chan ◽  
Po Yee Chung ◽  
Yuan Yuan Zhou ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Quinoline Derivative ◽  
Down Regulation ◽  
Anti Cancer ◽  
Cox 2

scholarly journals Metformin Inhibits Esophageal Squamous Cell Carcinoma Viability and Mobility in vitro through Down-regulation of Long Non-coding RNA CCAT1 and SPRY4-IT1

2021 ◽  
Author(s):  
Min Zhang ◽  
Jixia Wang ◽  
Yichun Li ◽  
Lei Qin ◽  
Ruijuan Fan ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Down Regulation ◽  
Non Coding Rna ◽  
Anti Cancer

Evidence indicates that the long noncoding RNAs are involved in the metformin-mediated anti-cancer processes. However, the potential effects of the long noncoding RNAs in metformin-mediated anti-tumor processes in esophageal squamous cell carcinomas (ESCC) are still elusive. This study uncovered that metformin decreases the level of long noncoding RNAs CCAT1 and SPRY4-IT1 thereby contributing to the down-regulation of c-Myc and vimentin. Also, the RNA level test of human ESCC tissue confirmed the positive correlation between CCAT1 and c-Myc. These findings demonstrated that metformin facilitated anti-cancer effects by targeting the 2 long noncoding RNAs (CCAT1 and SPRY4-IT1) and their consequential targets c-Myc and vimentin. Therefore, the CCAT1 and SPRY4-IT1 might act as novel molecular targets that mediate the anti-tumor effects in esophageal squamous cell carcinoma. This helps in predicting the treatment response of metformin in patients diagnosed with esophageal squamous cell carcinoma.

Down-Regulation of miR-27a Might Reverse Multidrug Resistance of Esophageal Squamous Cell Carcinoma

2009 ◽  
Vol 55 (9) ◽  
pp. 2545-2551 ◽  
Author(s):  
Hongwei Zhang ◽  
Mengbin Li ◽  
Yu Han ◽  
Liu Hong ◽  
Taiqian Gong ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Multidrug Resistance ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Down Regulation

scholarly journals A COX-2 inhibitor enhances the antitumor effects of chemotherapy and radiotherapy for esophageal squamous cell carcinoma

2014 ◽  
Vol 44 (4) ◽  
pp. 1146-1152 ◽  
Author(s):  
GULBOSTAN YUSUP ◽  
YASUNORI AKUTSU ◽  
MURADIL MUTALLIP ◽  
WEI QIN ◽  
XIN HU ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Antitumor Effects ◽  
Cox 2

scholarly journals Podophyllotoxin Isolated from Podophyllum peltatum Induces G2/M Phase Arrest and Mitochondrial-Mediated Apoptosis in Esophageal Squamous Cell Carcinoma Cells

Forests ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 8 ◽  
Author(s):  
Goo Yoon ◽  
Mee-Hyun Lee ◽  
Ah-Won Kwak ◽  
Ha-Na Oh ◽  
Seung-Sik Cho ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Er Stress ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Podophyllum Peltatum ◽  
Phase Arrest ◽  
Anti Cancer ◽  
M Phase ◽  
Stress Dependent

Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers in East Asia and is the seventh leading cause of cancer deaths. Podophyllotoxin (PT), a cyclolignan isolated from podophyllum peltatum, exhibits anti-cancer effects at the cellular level. This study investigated the underlying mechanism of anti-cancer effects induced by PT in ESCC cells. Exposure to increasing concentrations of PT led to a significant decrease in the growth and anchorage-independent colony numbers of ESCC cells. PT showed high anticancer efficacy against a panel of four types of ESCC cells, including KYSE 30, KYSE 70, KYSE 410, KYSE 450, and KYSE 510 by IC50 at values ranges from 0.17 to 0.3 μM. We also found that PT treatment induced G2/M phase arrest in the cell cycle and accumulation of the sub-G1 population, as well as apoptosis. Exposure to PT triggered a significant synthesis of reactive oxygen species (ROS), a loss of mitochondrial membrane potential (MMP), and activation of various caspases. Furthermore, PT increased the levels of phosphorylated c-Jun N-terminal kinase (JNK), p38, and the expression of Endoplasmic reticulum (ER) stress marker proteins via ROS generation. An increase in the level of pro-apoptotic proteins and a reduction in the anti-apoptotic protein level induced ESCC cell death via the loss of MMP. Additionally, the release of cytochrome c into the cytosol with Apaf-1 induced the activation of multi-caspases. In conclusion, our results revealed that PT resulted in apoptosis of ESCC cells by modulating ROS-mediated mitochondrial and ER stress-dependent mechanisms. Therefore, PT is a promising therapeutic candidate as an anti-cancer drug against ESCC for clinical use.

scholarly journals Down-Regulation of MiR-1294 is Related to Dismal Prognosis of Patients with Esophageal Squamous Cell Carcinoma through Elevating C-MYC Expression

2015 ◽  
Vol 36 (1) ◽  
pp. 100-110 ◽  
Author(s):  
Kai Liu ◽  
Liyi Li ◽  
Aizemaiti Rusidanmu ◽  
Yongqing Wang ◽  
Xiayi Lv
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Cancer ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Pearson Correlation ◽  
Migration And Invasion ◽  
Down Regulation ◽  
Dismal Prognosis

Aims: Changes in the expression of microRNAs (miRNAs) have been found in many cancers. This study aimed to investigate the expression of miR-1294 in patients with esophageal squamous cell carcinoma (ESCC) and its effect on prognosis. The underlying mechanism was explored as well. Methods: We examined the expression of miRNA in human ESCC cancer tissues and adjacent non-tumor controls using quantitative reverse transcription polymerase chain reaction (qRT-PCR). And the relationship between expressions of miR-1294 and ESCC prognosis was analyzed in this study. Over-expression and knock-down methods were used to investigate the biological functions of miRNA-1294. The effect of miRNA-1294 on cell proliferation was evaluated by MTT. Besides, the function of miR-1294 on cell migration and invasion were evaluated by transwell assays. Results: MiR-1294 was significantly down-regulated in human ESCC tissues compared with the non-tumor controls tissues (P=0.014). And patients with low miR-1294 expression had a significantly poorer prognosis than those with a high miR-1294 expression (P=0.040). Negative association was defined between the expression of miR-1294 and the c-MYC expression in ESCC patients (Pearson correlation, r=-0.299, P=0.0079). Additionally, it was found that miR-1294 suppress esophageal cancer cells proliferation, migration and invasion capacity through targeting c-MYC in vitro. Conclusions: Down-regulation of miR-1294 correlates with poor prognosis of ESCC. It's partially due to the reduced function of c-MYC. This study may give insight into the understanding of pathogenesis of esophageal cancer and provide evidence for diagnosis and treatment of esophageal cancer.

Telomerase activity in esophageal squamous cell carcinoma: Down-regulation by chemotherapeutic agent

2001 ◽  
Vol 79 (1) ◽  
pp. 37-45 ◽  
Author(s):  
Akira Mitsui ◽  
Yoshiyuki Kuwabara ◽  
Hirotaka Iwase ◽  
Masami Mitani ◽  
Noriyuki Shinoda ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Chemotherapeutic Agent ◽  
Telomerase Activity ◽  
Down Regulation
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