Telomerase activity in esophageal squamous cell carcinoma: Down-regulation by chemotherapeutic agent

2001 ◽  
Vol 79 (1) ◽  
pp. 37-45 ◽  
Author(s):  
Akira Mitsui ◽  
Yoshiyuki Kuwabara ◽  
Hirotaka Iwase ◽  
Masami Mitani ◽  
Noriyuki Shinoda ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Chemotherapeutic Agent ◽  
Telomerase Activity ◽  
Down Regulation

Down-Regulation of miR-27a Might Reverse Multidrug Resistance of Esophageal Squamous Cell Carcinoma

2009 ◽  
Vol 55 (9) ◽  
pp. 2545-2551 ◽  
Author(s):  
Hongwei Zhang ◽  
Mengbin Li ◽  
Yu Han ◽  
Liu Hong ◽  
Taiqian Gong ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Multidrug Resistance ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Down Regulation

scholarly journals Down-Regulation of MiR-1294 is Related to Dismal Prognosis of Patients with Esophageal Squamous Cell Carcinoma through Elevating C-MYC Expression

2015 ◽  
Vol 36 (1) ◽  
pp. 100-110 ◽  
Author(s):  
Kai Liu ◽  
Liyi Li ◽  
Aizemaiti Rusidanmu ◽  
Yongqing Wang ◽  
Xiayi Lv
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Cancer ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Pearson Correlation ◽  
Migration And Invasion ◽  
Down Regulation ◽  
Dismal Prognosis

Aims: Changes in the expression of microRNAs (miRNAs) have been found in many cancers. This study aimed to investigate the expression of miR-1294 in patients with esophageal squamous cell carcinoma (ESCC) and its effect on prognosis. The underlying mechanism was explored as well. Methods: We examined the expression of miRNA in human ESCC cancer tissues and adjacent non-tumor controls using quantitative reverse transcription polymerase chain reaction (qRT-PCR). And the relationship between expressions of miR-1294 and ESCC prognosis was analyzed in this study. Over-expression and knock-down methods were used to investigate the biological functions of miRNA-1294. The effect of miRNA-1294 on cell proliferation was evaluated by MTT. Besides, the function of miR-1294 on cell migration and invasion were evaluated by transwell assays. Results: MiR-1294 was significantly down-regulated in human ESCC tissues compared with the non-tumor controls tissues (P=0.014). And patients with low miR-1294 expression had a significantly poorer prognosis than those with a high miR-1294 expression (P=0.040). Negative association was defined between the expression of miR-1294 and the c-MYC expression in ESCC patients (Pearson correlation, r=-0.299, P=0.0079). Additionally, it was found that miR-1294 suppress esophageal cancer cells proliferation, migration and invasion capacity through targeting c-MYC in vitro. Conclusions: Down-regulation of miR-1294 correlates with poor prognosis of ESCC. It's partially due to the reduced function of c-MYC. This study may give insight into the understanding of pathogenesis of esophageal cancer and provide evidence for diagnosis and treatment of esophageal cancer.

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