scholarly journals Chicken RNA-binding protein T-cell internal antigen-1 contributes to stress granule formation in chicken cells and tissues

2018 ◽  
Vol 19 (1) ◽  
pp. 3
Author(s):  
Yingjie Sun ◽  
Pin Zhang ◽  
Hang Zheng ◽  
Luna Dong ◽  
Lei Tan ◽  
...  
Keyword(s):  
T Cell ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Stress Granule ◽  
Granule Formation

scholarly journals The RNA binding protein Musashi1 regulates apoptosis, gene expression and stress granule formation in urothelial carcinoma cells

2010 ◽  
Vol 15 (5) ◽  
pp. 1210-1224 ◽  
Author(s):  
Parvaneh Nikpour ◽  
Modjtaba Emadi Baygi ◽  
Christine Steinhoff ◽  
Christiane Hader ◽  
Anna C. Luca ◽  
...  
Keyword(s):  
Gene Expression ◽  
Urothelial Carcinoma ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Carcinoma Cells ◽  
Stress Granule ◽  
Granule Formation ◽  
Apoptosis Gene

scholarly journals Role of the RNA-Binding Protein Nrd1 in Stress Granule Formation and Its Implication in the Stress Response in Fission Yeast

PLoS ONE ◽  
2012 ◽  
Vol 7 (1) ◽  
pp. e29683 ◽  
Author(s):  
Ryosuke Satoh ◽  
Akitomo Tanaka ◽  
Ayako Kita ◽  
Takahiro Morita ◽  
Yasuhiro Matsumura ◽  
...  
Keyword(s):  
Stress Response ◽  
Fission Yeast ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Stress Granule ◽  
Granule Formation

scholarly journals Cytoplasmic Granule Formation and Translational Inhibition of Nodaviral RNAs in the Absence of the Double-Stranded RNA Binding Protein B2

2013 ◽  
Vol 87 (24) ◽  
pp. 13409-13421 ◽  
Author(s):  
J. E. Petrillo ◽  
P. A. Venter ◽  
J. R. Short ◽  
R. Gopal ◽  
S. Deddouche ◽  
...  
Keyword(s):  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Cytoplasmic Granule ◽  
Granule Formation ◽  
Double Stranded Rna ◽  
Translational Inhibition

scholarly journals Cold-Inducible RNA Binding Protein as a Vaccination Platform to Enhance Immunotherapeutic Responses against Hepatocellular Carcinoma

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3397
Author(s):  
Leyre Silva ◽  
Josune Egea ◽  
Lorea Villanueva ◽  
Marta Ruiz ◽  
Diana Llopiz ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
T Cell ◽  
Rna Binding ◽  
Checkpoint Inhibitors ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
T Cell Responses ◽  
Tumor Infiltrating Lymphocytes ◽  
Cell Responses ◽  
Tlr4 Ligand

Therapies based on immune checkpoint inhibitors (ICPI) have yielded promising albeit limited results in patients with hepatocellular carcinoma (HCC). Vaccines have been proposed as combination partners to enhance response rates to ICPI. Thus, we analyzed the combined effect of a vaccine based on the TLR4 ligand cold-inducible RNA binding protein (CIRP) plus ICPI. Mice were immunized with vaccines containing ovalbumin linked to CIRP (OVA-CIRP), with or without ICPI, and antigen-specific responses and therapeutic efficacy were tested in subcutaneous and orthotopic mouse models of liver cancer. OVA-CIRP elicited polyepitopic T-cell responses, which were further enhanced when combined with ICPI (anti-PD-1 and anti-CTLA-4). Combination of OVA-CIRP with ICPI enhanced ICPI-induced therapeutic responses when tested in subcutaneous and intrahepatic B16-OVA tumors, as well as in the orthotopic PM299L HCC model. This effect was associated with higher OVA-specific T-cell responses in the periphery, although many tumor-infiltrating lymphocytes still displayed an exhausted phenotype. Finally, a new vaccine containing human glypican-3 linked to CIRP (GPC3-CIRP) induced clear responses in humanized HLA-A2.01 transgenic mice, which increased upon combination with ICPI. Therefore, CIRP-based vaccines may generate anti-tumor immunity to enhance ICPI efficacy in HCC, although blockade of additional checkpoint molecules and immunosuppressive targets should be also considered.

scholarly journals Regulation of Stress Granule Formation by Inflammation, Vascular Injury, and Atherosclerosis

2019 ◽  
Vol 39 (10) ◽  
pp. 2014-2027 ◽  
Author(s):  
Allison B. Herman ◽  
Milessa Silva Afonso ◽  
Sheri E. Kelemen ◽  
Mitali Ray ◽  
Christine N. Vrakas ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Rna Binding ◽  
Binding Protein ◽  
Muscle Cells ◽  
Stress Granule ◽  
Translation Initiation Factor ◽  
Initiation Factor ◽  
Granule Formation ◽  
Altered Expression

Objective: Stress granules (SGs) are dynamic cytoplasmic aggregates containing mRNA, RNA-binding proteins, and translation factors that form in response to cellular stress. SGs have been shown to contribute to the pathogenesis of several human diseases, but their role in vascular diseases is unknown. This study shows that SGs accumulate in vascular smooth muscle cells (VSMCs) and macrophages during atherosclerosis. Approach and Results: Immunohistochemical analysis of atherosclerotic plaques from LDLR − /− mice revealed an increase in the stress granule-specific markers Ras-G3BP1 (GTPase-activating protein SH3 domain-binding protein) and PABP (poly-A-binding protein) in intimal macrophages and smooth muscle cells that correlated with disease progression. In vitro, PABP+ and G3BP1+ SGs were rapidly induced in VSMC and bone marrow–derived macrophages in response to atherosclerotic stimuli, including oxidized low-density lipoprotein and mediators of mitochondrial or oxidative stress. We observed an increase in eIF2α (eukaryotic translation initiation factor 2-alpha) phosphorylation, a requisite for stress granule formation, in cells exposed to these stimuli. Interestingly, SG formation, PABP expression, and eIF2α phosphorylation in VSMCs is reversed by treatment with the anti-inflammatory cytokine interleukin-19. Microtubule inhibitors reduced stress granule accumulation in VSMC, suggesting cytoskeletal regulation of stress granule formation. SG formation in VSMCs was also observed in other vascular disease pathologies, including vascular restenosis. Reduction of SG component G3BP1 by siRNA significantly altered expression profiles of inflammatory, apoptotic, and proliferative genes. Conclusions: These results indicate that SG formation is a common feature of the vascular response to injury and disease, and that modification of inflammation reduces stress granule formation in VSMC.

scholarly journals Control of Thymic T Cell Maturation, Deletion and Egress by the RNA-Binding Protein HuR

2009 ◽  
Vol 182 (11) ◽  
pp. 6779-6788 ◽  
Author(s):  
Olympia Papadaki ◽  
Stavros Milatos ◽  
Sofia Grammenoudi ◽  
Neelanjan Mukherjee ◽  
Jack D. Keene ◽  
...  
Keyword(s):  
T Cell ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Cell Maturation ◽  
T Cell Maturation

scholarly journals The Stress Granule RNA-Binding Protein TIAR-1 Protects Female Germ Cells from Heat Shock in Caenorhabditis elegans

2016 ◽  
Vol 6 (4) ◽  
pp. 1031-1047 ◽  
Author(s):  
Gabriela Huelgas-Morales ◽  
Carlos Giovanni Silva-García ◽  
Laura S. Salinas ◽  
David Greenstein ◽  
Rosa E. Navarro
Keyword(s):  
Caenorhabditis Elegans ◽  
Heat Shock ◽  
Germ Cells ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Stress Granule
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