The RNA ‐binding protein and stress granule component ATAXIN ‐2 is expressed in mouse and human tissues associated with glaucoma pathogenesis

2021 ◽  
Author(s):  
Chad Sundberg ◽  
Monika Lakk ◽  
Sharan Paul ◽  
K. P. Figueroa ◽  
Daniel R. Scoles ◽  
...  
Keyword(s):  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Stress Granule ◽  
Human Tissues ◽  
Ataxin 2

scholarly journals The Stress Granule RNA-Binding Protein TIAR-1 Protects Female Germ Cells from Heat Shock in Caenorhabditis elegans

2016 ◽  
Vol 6 (4) ◽  
pp. 1031-1047 ◽  
Author(s):  
Gabriela Huelgas-Morales ◽  
Carlos Giovanni Silva-García ◽  
Laura S. Salinas ◽  
David Greenstein ◽  
Rosa E. Navarro
Keyword(s):  
Caenorhabditis Elegans ◽  
Heat Shock ◽  
Germ Cells ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Stress Granule

scholarly journals The RNA binding protein Musashi1 regulates apoptosis, gene expression and stress granule formation in urothelial carcinoma cells

2010 ◽  
Vol 15 (5) ◽  
pp. 1210-1224 ◽  
Author(s):  
Parvaneh Nikpour ◽  
Modjtaba Emadi Baygi ◽  
Christine Steinhoff ◽  
Christiane Hader ◽  
Anna C. Luca ◽  
...  
Keyword(s):  
Gene Expression ◽  
Urothelial Carcinoma ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Carcinoma Cells ◽  
Stress Granule ◽  
Granule Formation ◽  
Apoptosis Gene

scholarly journals The RNA-binding protein ATX-2 regulates cytokinesis through PAR-5 and ZEN-4

2016 ◽  
Vol 27 (20) ◽  
pp. 3052-3064 ◽  
Author(s):  
Megan M. Gnazzo ◽  
Eva-Maria E. Uhlemann ◽  
Alex R. Villarreal ◽  
Masaki Shirayama ◽  
Eddie G. Dominguez ◽  
...  
Keyword(s):  
Cell Division ◽  
Posttranscriptional Regulation ◽  
Direct Evidence ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Spindle Midzone ◽  
Ataxin 2 ◽  
Temporal And Spatial

The spindle midzone harbors both microtubules and proteins necessary for furrow formation and the completion of cytokinesis. However, the mechanisms that mediate the temporal and spatial recruitment of cell division factors to the spindle midzone and midbody remain unclear. Here we describe a mechanism governed by the conserved RNA-binding protein ATX-2/Ataxin-2, which targets and maintains ZEN-4 at the spindle midzone. ATX-2 does this by regulating the amount of PAR-5 at mitotic structures, particularly the spindle, centrosomes, and midbody. Preventing ATX-2 function leads to elevated levels of PAR-5, enhanced chromatin and centrosome localization of PAR-5–GFP, and ultimately a reduction of ZEN-4–GFP at the spindle midzone. Codepletion of ATX-2 and PAR-5 rescued the localization of ZEN-4 at the spindle midzone, indicating that ATX-2 mediates the localization of ZEN-4 upstream of PAR-5. We provide the first direct evidence that ATX-2 is necessary for cytokinesis and suggest a model in which ATX-2 facilitates the targeting of ZEN-4 to the spindle midzone by mediating the posttranscriptional regulation of PAR-5.

scholarly journals Chicken RNA-binding protein T-cell internal antigen-1 contributes to stress granule formation in chicken cells and tissues

2018 ◽  
Vol 19 (1) ◽  
pp. 3
Author(s):  
Yingjie Sun ◽  
Pin Zhang ◽  
Hang Zheng ◽  
Luna Dong ◽  
Lei Tan ◽  
...  
Keyword(s):  
T Cell ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Stress Granule ◽  
Granule Formation

scholarly journals Distinct modes of stress granule assembly mediated by the KH-type RNA-binding protein Rnc1

2018 ◽  
Vol 23 (9) ◽  
pp. 778-785 ◽  
Author(s):  
Ryosuke Satoh ◽  
Nobuki Hara ◽  
Aki Kawasaki ◽  
Teruaki Takasaki ◽  
Reiko Sugiura
Keyword(s):  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Stress Granule

scholarly journals Role of the RNA-Binding Protein Nrd1 in Stress Granule Formation and Its Implication in the Stress Response in Fission Yeast

PLoS ONE ◽  
2012 ◽  
Vol 7 (1) ◽  
pp. e29683 ◽  
Author(s):  
Ryosuke Satoh ◽  
Akitomo Tanaka ◽  
Ayako Kita ◽  
Takahiro Morita ◽  
Yasuhiro Matsumura ◽  
...  
Keyword(s):  
Stress Response ◽  
Fission Yeast ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Stress Granule ◽  
Granule Formation

235: The RNA-Binding Protein IMP3: A Novel Molecular Marker Predicts Progression of Superficial (TA and T1) Urothelial Carcinomas of Bladder

2007 ◽  
Vol 177 (4S) ◽  
pp. 78-79
Author(s):  
Lioudmila Sitnikova ◽  
Gary Mendese ◽  
Qin Lui ◽  
Bruce A. Woda ◽  
Di Lu ◽  
...  
Keyword(s):  
Molecular Marker ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Urothelial Carcinomas
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