scholarly journals Aristolochia manshuriensisKom ethyl acetate extract protects against high-fat diet-induced non-alcoholic steatohepatitis by regulating kinase phosphorylation in mouse

2016 ◽  
Vol 17 (3) ◽  
pp. 279 ◽  
Author(s):  
Dong Hoon Kwak ◽  
Ji-Su Kim ◽  
Kyu-Tae Chang ◽  
Young-Kug Choo
Keyword(s):  
Ethyl Acetate ◽  
High Fat Diet ◽  
Ethyl Acetate Extract ◽  
High Fat ◽  
Alcoholic Steatohepatitis ◽  
Kinase Phosphorylation

scholarly journals The Ethyl Acetate Extract of Leaves of Ugni molinae Turcz. Improves Neuropathological Hallmarks of Alzheimer’s Disease in Female APPswe/PS1dE9 Mice Fed with a High Fat Diet

2018 ◽  
Vol 66 (3) ◽  
pp. 1175-1191 ◽  
Author(s):  
Daniela Jara-Moreno ◽  
Rubn D. Castro-Torres ◽  
Miren Ettcheto ◽  
Carme Auladell ◽  
Marcelo J. Kogan ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Ethyl Acetate ◽  
High Fat Diet ◽  
Ethyl Acetate Extract ◽  
High Fat ◽  
Ugni Molinae

scholarly journals Metabolomic profiling reveals effects of marein on energy metabolism in HepG2 cells

2017 ◽  
Author(s):  
Baoping Jiang ◽  
Liang Le ◽  
Keping Hu ◽  
Lijia Xu ◽  
Peigen Xiao
Keyword(s):  
Insulin Resistance ◽  
Ethyl Acetate ◽  
High Glucose ◽  
High Fat Diet ◽  
Hepg2 Cells ◽  
Ethyl Acetate Extract ◽  
Glycogen Synthesis ◽  
High Fat ◽  
Protein Levels ◽  
Coreopsis Tinctoria

AbstractPrevious studies have suggested thatCoreopsis tinctoriaimproves insulin resistance in rats fed with high-fat diet. But little is known about the antidiabetic effects of marein which is the main component ofC. tinctoria. This study investigated the effects of ethyl acetate extract ofC. tinctoria(AC) on insulin resistance (IR) in rats fed a high-fat diet. High glucose and fat conditions cause a significant increase in blood glucose, insulin, serum TC,TG and LDL-C, leading to an abnormal IR in rats. However, treatment with AC protects against HFD-induced IR by improving fasting serum glucose and lipid homeostasis. High glucose conditions cause a significant decrease in glycogen synthesis and increases PEPCK and G6Pase protein levels and Krebs-cycle-related enzymes levels, leading to an abnormal metabolic state in HepG2 Cells. However, treatment with Marein improves IR by increasing glucose uptake and glycogen synthesis and by downregulating PEPCK and G6Pase protein levels. The statistical analysis of HPLC/MS data demonstrates that Marein restores the normal metabolic state. The results show that AC ameliorates IR in rats and Marein has the potential effect in improving IR by ameliorating glucose metabolic disorders.AbbreviationsACethyl acetate extract ofCoreopsis tinctoriaTCATricarboxylic acidHepG2hepatocellular carcinoma cell line2-NBDG2-(N-(7-nitrobenz-2-oxa-1, 3-diazol-4-yl) amino)-2-deoxyglucoseG6Paseglucose-6-phosphatasePEPCKphosphoenolpyruvate carboxykinaseIRinsulin resistanceHFDhigh-fat dietSDHAsuccinate dehydrogenase flavoprotein subunitACO2aconitase 2IDH2isocitrate dehydrogenase 2CScitrate synthaseFHfumarate hydrataseMDH2malate dehydrogenaseDLSTdihydrolipoamide S-succinyltransferase

scholarly journals Ethyl Acetate Fraction of Amomum xanthioides Ameliorates Nonalcoholic Fatty Liver Disease in a High-Fat Diet Mouse Model

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2433
Author(s):  
Hwi-Jin Im ◽  
Seung-Ju Hwang ◽  
Jin-Seok Lee ◽  
Sung-Bae Lee ◽  
Ji-Yun Kang ◽  
...  
Keyword(s):  
Liver Disease ◽  
Mouse Model ◽  
Fatty Liver ◽  
Ethyl Acetate ◽  
Nonalcoholic Fatty Liver Disease ◽  
High Fat Diet ◽  
Fatty Liver Disease ◽  
Ethyl Acetate Fraction ◽  
High Fat ◽  
Nonalcoholic Fatty Liver

The global prevalence of nonalcoholic fatty liver disease (NAFLD) is estimated to be 25% and has continued to increase; however, no drugs have yet been approved for NAFLD treatments. The ethyl acetate fraction of Amomum xanthioides (EFAX) was previously reported to have an anti-hepatic fibrosis effect, but its effects on steatosis or steatohepatitis remain unclear. This study investigated the anti-fatty liver of EFAX using a high-fat diet mouse model. High-fat diet intake for 8 weeks induced hepatic steatosis with mild inflammation and oxidative damage and increased the adipose tissue weight along with the development of dyslipidemia. EFAX treatment significantly ameliorated the steatohepatic changes, the increased weight of adipose tissues, and the altered serum lipid profiles. These observed effects were possibly due to the lipolysis-dominant activity of EFAX on multiple hepatic proteins including sterol regulatory element-binding protein (mSREBP)-1c, peroxisome proliferator-activated receptor (PPAR)-α, AMP-activated protein kinase, and diglyceride acyltransferases (DGATs). Taken together, these results show that EFAX might be a potential therapeutic agent for regulating a wide spectrum of NAFLDs from steatosis to fibrosis via multiple actions on lipid metabolism-related proteins. Further studies investigating clear mechanisms and their active compounds are needed.

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