scholarly journals Geniposide and Chlorogenic Acid Combination Ameliorates Non-alcoholic Steatohepatitis Involving the Protection on the Gut Barrier Function in Mouse Induced by High-Fat Diet

2018 ◽  
Vol 9 ◽  
Author(s):  
Jing-hua Peng ◽  
Jing Leng ◽  
Hua-jie Tian ◽  
Tao Yang ◽  
Yi Fang ◽  
...  
Keyword(s):  
Chlorogenic Acid ◽  
Barrier Function ◽  
High Fat Diet ◽  
High Fat ◽  
Gut Barrier ◽  
Alcoholic Steatohepatitis ◽  
Gut Barrier Function

High Fat Diet and Gut Barrier Function

2013 ◽  
Vol 9 (2) ◽  
pp. 108-112
Author(s):  
A.C. van den Heijkant ◽  
M.D.P Luyer ◽  
W.A. Buurman
Keyword(s):  
Barrier Function ◽  
High Fat Diet ◽  
High Fat ◽  
Gut Barrier ◽  
Gut Barrier Function

scholarly journals 53 The Maternal Microbiota Influences the Post-Natal Development of Gut Barrier Function and Immune System in Piglets and Their Gut Adaptation to a High Fat Diet Later in Life

2012 ◽  
Vol 142 (5) ◽  
pp. S-14
Author(s):  
Gaelle Boudry ◽  
Stephanie Ferret-Bernard ◽  
Gerard Savary ◽  
Laurence Le Normand ◽  
Cecile Perrier ◽  
...  
Keyword(s):  
Immune System ◽  
Barrier Function ◽  
High Fat Diet ◽  
High Fat ◽  
Gut Barrier ◽  
Gut Barrier Function

High-fat enteral nutrition decreases TNF-alpha and preserves gut barrier function in rats after hemorrhagic shock

2003 ◽  
Vol 22 ◽  
pp. S38
Author(s):  
M.D.P. Luyer ◽  
M. Hadfoune ◽  
J.A. Jacobs ◽  
C.H.C. Dejong ◽  
W.A. Buurman ◽  
...  
Keyword(s):  
Enteral Nutrition ◽  
Hemorrhagic Shock ◽  
Barrier Function ◽  
Tnf Alpha ◽  
High Fat ◽  
Gut Barrier ◽  
Gut Barrier Function

scholarly journals A novel mechanism for gut barrier dysfunction by dietary fat: epithelial disruption by hydrophobic bile acids

2013 ◽  
Vol 304 (3) ◽  
pp. G227-G234 ◽  
Author(s):  
Lotta K. Stenman ◽  
Reetta Holma ◽  
Ariane Eggert ◽  
Riitta Korpela
Keyword(s):  
Bile Acids ◽  
Dietary Fat ◽  
Barrier Function ◽  
High Fat Diet ◽  
High Fat ◽  
Barrier Dysfunction ◽  
Gut Barrier ◽  
Epithelial Integrity

Impairment of gut barrier is associated with a fat-rich diet, but mechanisms are unknown. We have earlier shown that dietary fat modifies fecal bile acids in mice, decreasing the proportion of ursodeoxycholic acid (UDCA) vs. deoxycholic acid (DCA). To clarify the potential role of bile acids in fat-induced barrier dysfunction, we here investigated how physiological concentrations of DCA and UDCA affect barrier function in mouse intestinal tissue. Bile acid experiments were conducted in vitro in Ussing chambers using 4- and 20-kDa FITC-labeled dextrans. Epithelial integrity and inflammation were assayed by histology and Western blot analysis for cyclooxygenase-2. LPS was studied in DCA-induced barrier dysfunction. Finally, we investigated in a 10-wk in vivo feeding trial in mice the barrier-disrupting effect of a diet containing 0.1% DCA. DCA disrupted epithelial integrity dose dependently at 1–3 mM, which correspond to physiological concentrations on a high-fat diet. Low-fat diet-related concentrations of DCA had no effect. In vivo, the DCA-containing diet increased intestinal permeability 1.5-fold compared with control ( P = 0.016). Hematoxylin-eosin staining showed a clear disruption of the epithelial barrier by 3 mM DCA in vitro. A short-term treatment by DCA did not increase cyclooxygenase-2 content in colon preparations. UDCA did not affect barrier function itself, but it ameliorated DCA-induced barrier disruption at a 0.6 mM concentration. LPS had no significant effect on barrier function at 0.5–4.5 μg/ml concentrations. We suggest a novel mechanism for barrier dysfunction on a high-fat diet involving the effect of hydrophobic luminal bile acids.

scholarly journals Chlorogenic Acid Protects against Advanced Alcoholic Steatohepatitis in Rats via Modulation of Redox Homeostasis, Inflammation, and Lipogenesis

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 4155
Author(s):  
Vyacheslav Buko ◽  
Ilya Zavodnik ◽  
Grażyna Budryn ◽  
Małgorzata Zakłos-Szyda ◽  
Elena Belonovskaya ◽  
...  
Keyword(s):  
Chlorogenic Acid ◽  
High Fat Diet ◽  
Redox Homeostasis ◽  
Therapeutic Effects ◽  
High Fat ◽  
Regulation Of Expression ◽  
Alcoholic Steatohepatitis ◽  
Expression Of Genes ◽  
Genes Encoding ◽  
Liver Triglycerides

The aim of this study was to evaluate the therapeutic effects of chlorogenic acid (CGA) in rats with advanced alcoholic steatohepatitis. The rats were fed on a high-fat diet and gavaged with ethanol (4 g/kg) for 8 weeks. The livers of ethanol-treated rats showed steatosis; necrosis and mononuclear infiltration; and significant upregulation of the mRNA expression of the prooxidant (Cyp2e1, iNos), lipogenic (Srebp1, Acc), proinflammatory (Tlr4, Nf-κb, TnfA, Il-1B, and Il-6), and profibrogenic (TgfB, Col1, VegfA) genes. Simultaneously, a downregulation of level of Sod and Nrf2 was observed, which was accompanied by increased serum transaminase, TnfA, and serum and liver triglycerides levels. CGA administration (40 and 80 mg/kg, 8 weeks) to ethanol-fed group reduced the liver expression levels of Cyp2e1 and iNos, whereas it markedly enhanced the expression of Sod, Nrf2, and Ho-1. CGA at both doses downregulated the expressions of lipogenic, proinflammatory, and profibrogenic genes, while the expression of Tlr4 was lowered only after the higher dose of CGA. The higher dose of CGA efficiently prevented the progression of alcohol-induced steatosis and reduced inflammation through regulation of the expression of genes encoding the proteins involved in the Tlr4/Nf-κB signaling pathway and fibrosis. The study revealed hepatoprotective and anti-inflammatory effects of CGA through the regulation of expression of genes encoding Cyp2e1/Nrf2 involved in oxidative stress modulation. These results demonstrate CGA as a therapeutic candidate for the prevention and treatment of alcoholic steatohepatitis.

scholarly journals Reduced obesity, diabetes, and steatosis upon cinnamon and grape pomace are associated with changes in gut microbiota and markers of gut barrier

2018 ◽  
Vol 314 (4) ◽  
pp. E334-E352 ◽  
Author(s):  
Matthias Van Hul ◽  
Lucie Geurts ◽  
Hubert Plovier ◽  
Céline Druart ◽  
Amandine Everard ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
Metabolic Profile ◽  
Liver Steatosis ◽  
Grape Pomace ◽  
Metabolic Effects ◽  
High Fat ◽  
Gut Barrier ◽  
Microbial Composition ◽  
Gut Barrier Function

Increasing evidence suggests that polyphenols have a significant potential in the prevention and treatment of risk factors associated with metabolic syndrome. The objective of this study was to assess the metabolic outcomes of two polyphenol-containing extracts from cinnamon bark (CBE) and grape pomace (GPE) on C57BL/6J mice fed a high-fat diet (HFD) for 8 wk. Both CBE and GPE were able to decrease fat mass gain and adipose tissue inflammation in mice fed a HFD without reducing food intake. This was associated with reduced liver steatosis and lower plasma nonesterified fatty acid levels. We also observed a beneficial effect on glucose homeostasis, as evidenced by an improved glucose tolerance and a lower insulin resistance index. These ameliorations of the overall metabolic profile were associated with a significant impact on the microbial composition, which was more profound for the GPE than for the CBE. At the genus level, Peptococcus were decreased in the CBE group. In the GPE-treated group, several key genera that have been previously found to be linked with HFD, metabolic effects, and gut barrier integrity were affected: we observed a decrease of Desulfovibrio, Lactococcus, whereas Allobaculum and Roseburia were increased. In addition, the expression of several antimicrobial peptides and tight junction proteins was increased in response to both CBE and GPE supplementation, indicating an improvement of the gut barrier function. Collectively, these data suggest that CBE and GPE can ameliorate the overall metabolic profile of mice on a high-fat diet, partly by acting on the gut microbiota.

Effect of high-fat enteral nutrition on inflammation and gut barrier function in rats after hemorrhagic shock

2003 ◽  
Vol 124 (4) ◽  
pp. A339
Author(s):  
Misha D. Luyer ◽  
Jan A. Jacobs ◽  
M'Hamed Hadfoune ◽  
Anita C. Vreugdenhil ◽  
Cornelis H. Dejong ◽  
...  
Keyword(s):  
Enteral Nutrition ◽  
Hemorrhagic Shock ◽  
Barrier Function ◽  
High Fat ◽  
Gut Barrier ◽  
Gut Barrier Function
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