scholarly journals Increased humoral antibody response of foot-and-mouth disease virus vaccine in growing pigs pre-treated with poly-γ-glutamic acid

2016 ◽  
Vol 17 (2) ◽  
pp. 253 ◽  
Author(s):  
Jee-Hoon Lee ◽  
Ik-Jae Kang ◽  
A-Reum Kim ◽  
You-Sun Noh ◽  
Hee-Chun Chung ◽  
...  
Keyword(s):  
Antibody Response ◽  
Glutamic Acid ◽  
Disease Virus ◽  
Virus Vaccine ◽  
Foot And Mouth Disease ◽  
Growing Pigs ◽  
Mouth Disease ◽  
Humoral Antibody ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals Induction of a protective response in swine vaccinated with DNA encoding foot-and-mouth disease virus empty capsid proteins and the 3D RNA polymerase

2001 ◽  
Vol 82 (7) ◽  
pp. 1713-1724 ◽  
Author(s):  
Leticia Cedillo-Barrón ◽  
Mildred Foster-Cuevas ◽  
Graham J. Belsham ◽  
François Lefèvre ◽  
R. Michael E. Parkhouse
Keyword(s):  
Antibody Response ◽  
Disease Virus ◽  
Dna Vaccine ◽  
Virus Vaccine ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Structural Protein ◽  
Live Virus ◽  
Mouth Disease Virus ◽  
Foot And Mouth

This work focuses on the development of a potential recombinant DNA vaccine against foot-and-mouth disease virus (FMDV). Such a vaccine would have significant advantages over the conventional inactivated virus vaccine, in particular having none of the risks associated with the high security requirements for working with live virus. The principal aim of this strategy was to stimulate an antibody response to native, neutralizing epitopes of empty FMDV capsids generated in vivo. Thus, a plasmid (pcDNA3.1/P1–2A3C3D) was constructed containing FMDV cDNA sequences encoding the viral structural protein precursor P1–2A and the non-structural proteins 3C and 3D. The 3C protein was included to ensure cleavage of the P1–2A precursor to VP0, VP1 and VP3, the components of self-assembling empty capsids. The non-structural protein 3D was also included in the construct in order to provide additional stimulation of CD4+ T cells. When swine were immunized with this plasmid, antibodies to FMDV and the 3D polymerase were synthesized. Furthermore, neutralizing antibodies were detected and, after three sequential vaccinations with DNA, some of the animals were protected against challenge with live virus. Additional experiments suggested that the antibody response to FMDV proteins was improved by the co-administration of a plasmid encoding porcine granulocyte–macrophage colony-stimulating factor. Although still not as effective as the conventional virus vaccine, the results encourage further work towards the development of a DNA vaccine against FMDV.

The immunopotentiator CVC1302 enhances immune efficacy and protective ability of foot-and-mouth disease virus vaccine in pigs

Vaccine ◽  
2018 ◽  
Vol 36 (52) ◽  
pp. 7929-7935 ◽  
Author(s):  
Jin Chen ◽  
Xiaoming Yu ◽  
Qisheng Zheng ◽  
Liting Hou ◽  
Luping Du ◽  
...  
Keyword(s):  
Disease Virus ◽  
Virus Vaccine ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Protective Ability ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
Immune Efficacy

Immune response of calves to foot-and-mouth disease virus vaccine emulsified with oil adjuvant. Strategies of vaccination

Vaccine ◽  
1995 ◽  
Vol 13 (10) ◽  
pp. 909-914 ◽  
Author(s):  
E.J.A. Späth ◽  
E. Smitsaart ◽  
A.P.E. Casaro ◽  
N. Fondevila ◽  
F. Fernández ◽  
...  
Keyword(s):  
Immune Response ◽  
Disease Virus ◽  
Virus Vaccine ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Foot And Mouth
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