scholarly journals Dietary germanium biotite supplementation enhances the induction of antibody responses to foot-and-mouth disease virus vaccine in pigs

2014 ◽  
Vol 15 (3) ◽  
pp. 443 ◽  
Author(s):  
Jin-A Lee ◽  
Bock-Gie Jung ◽  
Myunghwan Jung ◽  
Tae-Hoon Kim ◽  
Han Sang Yoo ◽  
...  
Keyword(s):  
Disease Virus ◽  
Virus Vaccine ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Antibody Responses ◽  
Mouth Disease Virus ◽  
Foot And Mouth

The immunopotentiator CVC1302 enhances immune efficacy and protective ability of foot-and-mouth disease virus vaccine in pigs

Vaccine ◽  
2018 ◽  
Vol 36 (52) ◽  
pp. 7929-7935 ◽  
Author(s):  
Jin Chen ◽  
Xiaoming Yu ◽  
Qisheng Zheng ◽  
Liting Hou ◽  
Luping Du ◽  
...  
Keyword(s):  
Disease Virus ◽  
Virus Vaccine ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Protective Ability ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
Immune Efficacy

Immune response of calves to foot-and-mouth disease virus vaccine emulsified with oil adjuvant. Strategies of vaccination

Vaccine ◽  
1995 ◽  
Vol 13 (10) ◽  
pp. 909-914 ◽  
Author(s):  
E.J.A. Späth ◽  
E. Smitsaart ◽  
A.P.E. Casaro ◽  
N. Fondevila ◽  
F. Fernández ◽  
...  
Keyword(s):  
Immune Response ◽  
Disease Virus ◽  
Virus Vaccine ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals Isotype-specific antibody responses to foot-and-mouth disease virus in sera and secretions of ‘carrier’ and ‘non-carrier’ cattle

1996 ◽  
Vol 117 (2) ◽  
pp. 349-360 ◽  
Author(s):  
J. S. Salt ◽  
G. Mulcahy ◽  
R. P. Kitching
Keyword(s):  
Disease Virus ◽  
Specific Antibody ◽  
Statistical Significance ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Antibody Responses ◽  
Upper Respiratory Tract ◽  
Serum Samples ◽  
Mouth Disease Virus ◽  
Foot And Mouth

SummaryIsotype-specific antibody responses to foot-and-mouth disease virus (FMDV) were measured in the sera and upper respiratory tract secretions of vaccinated and susceptible cattle challenged with FMDV by direct contact or by intranasal inoculation. A comparison was made between cattle that eliminated FMDV and those that developed and maintained a persistent infection. Serological and mucosal antibody responses were detected in all animals after challenge. IgA and 1gM were detected before the development of IgG1and IgG2responses. 1gM was not detected in vaccinated cattle. Challenge with FMDV elicited a prolonged biphasic secretory antibody response in FMDV ‘carrier’ animals only. The response was detected as FMDVspecific IgA in both mucosal secretions and serum samples, which gained statistical significance (P< 0·05) by 5 weeks after challenge. This observation could represent the basis of a test to differentiate vaccinated and/or recovered convalescent cattle from FMDV ‘carriers’.

scholarly journals Enhanced Stability of Inactivated Foot-And-Mouth Disease Virus Vaccine With A Novel Solution Buffer.

2021 ◽  
Author(s):  
Jing Li ◽  
Yanming Wei ◽  
Rong Zhang ◽  
Huiqing Yang ◽  
Xuerong Liu
Keyword(s):  
Disease Virus ◽  
Virus Vaccine ◽  
Vaccine Development ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Size Exclusion ◽  
Basic Solution ◽  
The Novel ◽  
Mouth Disease Virus ◽  
Foot And Mouth

Abstract Objectives: Stability is vital for potency of food-and-mouth disease virus vaccine preparation. However, the assembly of inactivated foot-and-mouth disease virus is poor stable and prone to dissociate into 12s under mild acidic or heating conditions, especially emulsified with oil-adjuvant. Thus, it is crucial to explore a suitable medium and condition to improve the stability and efficiency of inactivated FMDV vaccine. Results: In this study, the basic solution buffer and a serious of potential stabilizers, such as carbohydrate, amino acid, antioxidant, salt and antioxidant were screened for evaluating stable effect on FMDV antigen with aid of high performance size exclusion chromatography (HPSEC). On this basis, orthogonal experiment was performed to optimize and finally confirm the formulation. Anti-aging test were carried out to asses the efficiency of formulation on vaccine stability and the results showed that the vaccine was more stabler either stored at 37℃or 4℃. Moreover, physicochemical monitoring revealed that formulation had no influence on the properties of vaccine. The combined results suggested that the novel solution buffer would lower degradation and prolong shelf life of vaccine. In a word, the novel buffer is beneficial to make FMD vaccine more stable and effective, reducing the dependence on cold delivery and storage. This study also provides insight into the processes of optimization and inactivated vaccine development.

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