scholarly journals Effects of aluminum on the reduction of neural stem cells, proliferating cells, and differentiating neuroblasts in the dentate gyrus of D-galactose-treated mice via increasing oxidative stress

2016 ◽  
Vol 17 (2) ◽  
pp. 127 ◽  
Author(s):  
Sung Min Nam ◽  
Jong Whi Kim ◽  
Dae Young Yoo ◽  
Woosuk Kim ◽  
Hyo Young Jung ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stem Cells ◽  
Neural Stem Cells ◽  
Dentate Gyrus ◽  
Proliferating Cells

Neuroprotective effects of amlodipine besylate and benidipine hydrochloride on oxidative stress-injured neural stem cells

2014 ◽  
Vol 1551 ◽  
pp. 1-12 ◽  
Author(s):  
Na-Young Choi ◽  
Hojin Choi ◽  
Hyun-Hee Park ◽  
Eun-Hye Lee ◽  
Hyun-Jeung Yu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stem Cells ◽  
Neural Stem Cells ◽  
Amlodipine Besylate ◽  
Neuroprotective Effects

scholarly journals Dual Specificity Phosphatase 6 Protects Neural Stem Cells from β-Amyloid-Induced Cytotoxicity through ERK1/2 Inactivation

Biomolecules ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 181 ◽  
Author(s):  
Wang Liao ◽  
Yuqiu Zheng ◽  
Wenli Fang ◽  
Shaowei Liao ◽  
Ying Xiong ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stem Cells ◽  
Neural Stem Cells ◽  
Western Blot ◽  
Mitochondrial Dysfunction ◽  
Neuroprotective Effect ◽  
Dependent Manner ◽  
Dual Specificity Phosphatase ◽  
Cell Vitality ◽  
Dual Specificity

Alzheimer’s disease (AD) is a devastating neurodegenerative disease with limited treatment options and no cure. Beta-amyloid (Aβ) is a hallmark of AD that has potent neurotoxicity in neural stem cells (NSCs). Dual specificity phosphatase 6 (DUSP6) is a member of the mitogen-activated protein kinases (MAPKs), which is involved in regulating various physiological and pathological processes. Whether DUSP6 has a protective effect on Aβ-induced NSC injury remains to be explored. C17.2 neural stem cells were transfected with DUSP6-overexpressed plasmid. NSCs with or without DUSP6 overexpression were administrated with Aβ25–35 at various concentrations (i.e., 0, 2.5, 5 μM). DUSP6 expression after Aβ treatment was detected by Real-Time Polymerase Chain Reaction (RT-PCR) and Western blot and cell vitality was examined by the CCK8 assay. The oxidative stress (intracellular reactive oxygen species (ROS) and malondialdehyde (MDA)), endoplasmic reticulum stress (ER calcium level) and mitochondrial dysfunction (cytochrome c homeostasis) were tested. The expression of p-ERK1/2 and ERK1/2 were assayed by Western blot. Our results showed that Aβ decreased the expression of DUSP6 in a dose-dependent manner. The overexpression of DUSP6 increased the cell vitality of NSCs after Aβ treatment. Oxidative stress, ER stress, and mitochondrial dysfunction induced by Aβ could be restored by DUSP6 overexpression. Additionally, the Aβ-induced ERK1/2 activation was reversed. In summary, DUSP6 might have a neuroprotective effect on Aβ-induced cytotoxicity, probably via ERK1/2 activation.

scholarly journals Microarray Analyses Support a Role for Nurr1 in Resistance to Oxidative Stress and Neuronal Differentiation in Neural Stem Cells

Stem Cells ◽  
2007 ◽  
Vol 25 (2) ◽  
pp. 511-519 ◽  
Author(s):  
Kyle M. Sousa ◽  
Helena Mira ◽  
Anita C. Hall ◽  
Lottie Jansson-Sjöstrand ◽  
Moriaki Kusakabe ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stem Cells ◽  
Neural Stem Cells ◽  
Neuronal Differentiation ◽  
Microarray Analyses

scholarly journals The Ventral Hippocampus Is the Embryonic Origin for Adult Neural Stem Cells in the Dentate Gyrus

Neuron ◽  
2013 ◽  
Vol 78 (4) ◽  
pp. 658-672 ◽  
Author(s):  
Guangnan Li ◽  
Li Fang ◽  
Gloria Fernández ◽  
Samuel J. Pleasure
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Dentate Gyrus ◽  
Ventral Hippocampus ◽  
Adult Neural Stem Cells ◽  
Embryonic Origin

scholarly journals Forced mastication increases survival of adult neural stem cells in the hippocampal dentate gyrus

2012 ◽  
Vol 31 (2) ◽  
pp. 307-314 ◽  
Author(s):  
YUKI AKAZAWA ◽  
TAKAMASA KITAMURA ◽  
YURI FUJIHARA ◽  
YOSHITAKA YOSHIMURA ◽  
MASATO MITOME ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Dentate Gyrus ◽  
Hippocampal Dentate Gyrus ◽  
Adult Neural Stem Cells

scholarly journals Stabilization of Nrf2 by tBHQ Confers Protection against Oxidative Stress-Induced Cell Death in Human Neural Stem Cells

2004 ◽  
Vol 83 (2) ◽  
pp. 313-328 ◽  
Author(s):  
Jiang Li ◽  
Delinda Johnson ◽  
Marcus Calkins ◽  
Lynda Wright ◽  
Clive Svendsen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stem Cells ◽  
Cell Death ◽  
Neural Stem Cells ◽  
Human Neural Stem Cells

Dexamethasone Enhances Oxidative Stress-Induced Cell Death in Murine Neural Stem Cells

2012 ◽  
Vol 22 (2) ◽  
pp. 127-137 ◽  
Author(s):  
Henricus A. M. Mutsaers ◽  
Roshan Tofighi
Keyword(s):  
Oxidative Stress ◽  
Stem Cells ◽  
Cell Death ◽  
Neural Stem Cells
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