EFFECT OF PORCINE GROWTH HORMONE-RELEASING FACTOR (1-29)NH2 AND THYROTROPIN-RELEASING FACTOR ON PIG GROWTH PERFORMANCE
Sixty female pigs were divided into four treatment groups to evaluate the effect of chronic treatment with porcine growth hormone-releasing factor (pGRF), thyrotropin-releasing factor (TRF) and their combination on growth performance of Yorkshire-Landrace pigs. Animals were injected with either saline, pGRF(1-29)NH2 at 15 μg kg−1 BW, TRF at 6 μg kg−1 BW, or pGRF plus TRF at doses previously mentioned, according to a 2 × 2 factorial design, using three pens of five pigs per treatment. Subcutaneous injections were made twice daily from 19.4 ± 0.8 to 95.2 ± 0.5 kg BW. Treatments did not affect (P > 0.05) average daily weight gain, feed consumption, feed efficiency or age at slaughter. TRF had no effect (P > 0.05) on carcass and blood variables except for reducing lung weight (P < 0.05) and increasing blood-urea nitrogen after 4 wk of treatment. GRF reduced (P < 0.01) backfat thickness at the level of the first thoracic rib, 13th thoracic rib, last lumbar vertebra and at 6.5 cm from the dorsal mid-line at the level of the 13th rib. Furthermore, pGRF increased carcass length, loin eye area at the 13th rib, lung weight and kidney weight. Blood glucose and free fatty acid concentrations were not affected (P > 0.05) by treatments. No significant pGRF × TRF interaction was observed for any measured variables. At the doses injected, TRF and pGRF did not modify growth variables, while pGRF positively affected carcass characteristics by reducing lipid content and increasing carcass length as well as loin eye area. Key words: Growth hormone-releasing factor, thyrotropin-releasing factor, pig, growth performance, carcass characteristics