GROWTH AND CARCASS COMPOSITION OF RAM LAMBS TREATED WITH CLONIDINE

1987 ◽  
Vol 67 (2) ◽  
pp. 417-425 ◽  
Author(s):  
A. D. KENNEDY ◽  
B. M. BELLUK
Keyword(s):  
Low Dose ◽  
Average Daily Gain ◽  
Carcass Composition ◽  
High Dose ◽  
Longissimus Dorsi Muscle ◽  
Kidney Fat ◽  
Ram Lambs ◽  
High Doses ◽  
Dependent Growth ◽  
Daily Gain

Average daily gain (ADG), feed efficiency and carcass composition were studied in ram lambs treated with a continuously administered low or high dose of clonidine. Groups of 10 Suffolk lambs and 10 Strain 2 lambs (a synthetic Finnish Landrace, Suffolk, Shropshire line) were implanted at 28-d intervals with Alzet® osmotic pumps containing either sterile H2O (control), a low dose of clonidine (5–8 μg kg−1 d−1; D) or a fivefold higher dose of clonidine (24–41 μg kg−1 d−1; 5D). The effect of clonidine on average daily gain was dose-, breed- and time-dependent. Growth response was only observed during the latter part of the trial. At this time the effects of both the low and high doses of clonidine were positive in Suffolk lambs whereas in Strain 2 lambs the effects were negative. Clonidine caused a reduction in dressing percent and kidney fat as a percentage of slaughter weight in a dose-related manner with the effect more pronounced in the fatter Strain 2 lambs. Percentage fat in the longissimus dorsi muscle of the 10th–12th rib section of lambs treated with the low dose of clonidine (3.42 ± 0.24) was greater than that of control lambs (2.55 ± 0.24) and lambs treated with the high dose of clonidine (2.52 ± 0.24). Key words: Clonidine, growth, carcass composition, lambs

scholarly journals Glucocorticoid Receptor Agonists to Improve the Productivity and Health of Early-Weaned Pigs: What Is the Best Method of Delivery?

Animals ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 1124
Author(s):  
Hailey Wooten ◽  
Hwanhee Kim ◽  
Amanda R. Rakhshandeh ◽  
Anoosh Rakhshandeh
Keyword(s):  
Body Weight ◽  
Glucocorticoid Receptor ◽  
Low Dose ◽  
Average Daily Gain ◽  
Feed Ratio ◽  
High Dose ◽  
Suitable Alternative ◽  
Treatment Groups ◽  
Daily Gain ◽  
All Treatment

The purpose of the current study was to determine the best method of delivery for glucocorticoid receptor agonist (GRA) treatment. A total of 167 Pig Improvement Company (PIC) piglets (body weight (BW) 7.35 ± 1.24 kg) were weaned at 25.0 ± 0.81 days of age and randomly assigned to 14 treatment groups based on a 2 × 7 factorial arrangement with sex (gilts vs. barrows), in-feed antibiotic (ANT; 110 mg/kg in-feed tylosin), repeated intramuscular (I.M.) injection of GRA (two injections, 0.2 mg/kg BW dexamethasone (DEX)), low dose in-feed GRA (LF, 2.5 mg/kg diet DEX ), high dose in-feed GRA (HF, 5 mg/kg diet DEX), low dose in-water GRA (LW, 0.8 mg/L DEX ), high dose in-water GRA (HW, 1.6 mg/L DEX ), and no treatment control (CON) as the main factors. Body weight and feed intake were measured daily from days 0 to 7 and weekly from days 7 to 28 post-weaning. The interaction effect for average daily gain (ADG) was significant with gilts performing better in the I.M., ANT, and LF groups (p = 0.05). All treatment groups, with the exception of the HW group, had a higher ADG than the CON group. Gilts in the I.M., LF, and HF groups had the highest ADG compared to other treatment groups (p ≤ 0.05). Sex and the interaction between sex and treatments had no effect on the gain-to-feed ratio (G:F; p ≥ 0.21). All treatment groups had a higher G:F than the CON group (p ≥ 0.04). These results suggest that the low-dose, in-feed GRA treatment is the best GRA delivery method and is a suitable alternative to in-feed sub-therapeutic antibiotics.

scholarly journals Evaluation of the BDNF, NGF, NT3 and NT4 Genes Expressions in the Brains of Neonatal Mice with Hypothyroidism

2017 ◽  
Vol 7 (1) ◽  
pp. 171
Author(s):  
Hamid Reza Adeli Bhroz ◽  
Kazem Parivar ◽  
Iraj Amiri ◽  
Nasim Hayati Roodbari
Keyword(s):  
Dose Group ◽  
Low Dose ◽  
Pure Water ◽  
Intervention Group ◽  
Control Group ◽  
High Dose ◽  
Endocrine Glands ◽  
Blood Samples ◽  
High Doses ◽  
The Brain

Background and Aim: Thyroid is one of the endocrine glands, (T3 and T4) play a significant role in the development of prenatal brain and the following stages. The study aimed to evaluate the effect of hypothyroidism on the amount of expression of NT4, NT3, nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in brain of one-day rat neonates with hypothyroidism.Materials and Methods: In total, 25 mature mice of Albino NMRI race were selected after mating, divided into three group, control, as well as low-dose and high-dose intervention groups. Samples of the control group received pure water during pregnancy, whereas subjects of the intervention group with low and high doses of the medication were administered with 20 mg and 100 mg methimazole powder (dissolved in 100 cc water), respectively. After child delivery, blood samples were obtained from mother mice to determine the level of T3 and T4 in blood serum. Following that, the brain of one-day mice were removed by surgery and assessed to determine the amount of expression of NT4, NT3, NGF and BDNF using the complete kit of RT-PCR.Results: Levels of T4 and T3 in the control group were 28 ug/dl and 1.59 ug/dl, respectively. In the low-dose intervention group, the amounts of the mentioned hormones were 8 ug/dl and 0.85 ug/dl, significantly, indicating a significant reduction in the expression of NT4, NT3, NGF and BDNF genes, compared to the control group. Moreover, T4 and T3 were 6 ug/dl and 0.79 ug/dl in the high-dose group, respectively, conveying a significant decrease in the expression of NT4, NT3, NGF and BDNF genes, compared to the control group (P<0.05).

PSXIII-15 Impact of forage allowance on performance and reproductive parameters in Nellore heifers

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 467-468
Author(s):  
Igor M Ferreira ◽  
Iorrano A Cidrini ◽  
Karla Oliveira ◽  
Luciana Sousa ◽  
Laura F Prados ◽  
...  
Keyword(s):  
Pregnancy Rate ◽  
Treatment Effect ◽  
Average Daily Gain ◽  
Experimental Period ◽  
Fixed Time ◽  
Carcass Composition ◽  
Stocking Rate ◽  
Treatment Conditions ◽  
To Receive ◽  
Daily Gain

Abstract The objective was to evaluate the effects of forage allowance on the performance and pregnancy rate of Nellore heifers submitted to the fixed-time artificial insemination (FTAI) at 14±1 months. The experimental period was divided into the growing phase (GP; 173d) and breeding season (83d). Ninety weaned Nellore heifers [169±19 kg of body weight (BW); 210±28 days of age] were blocked by initial BW and randomly assigned to receive different forage allowance: (1) High (HFA; 7.17 kgDM/kgBW; and (2) Low (LFA; 3.27 kgDM/kgBW); and divided into 6 paddocks (2.15 to 2.4 ha each one). The grazing method used was continuous stocking with a variable stocking rate where treatment conditions were established varying the stocking rate on pasture (put-and-take). The supplement consisted of corn, soybean meal, urea, monensin, sodium chloride and minerals mix (80% TDN and 24% CP) and was provided daily (ad libitum; expected intake around 1% of BW). The final pregnancy rate was determined after two FTAI (d256). Heifers BW at the end of the GP was greater (P &lt; 0.01) for HFA vs. LFA (268 vs. 255 kg). The overall average daily gain (ADG) was greater 68 g/d for animals maintained in HFA than LFA (P &lt; 0.01; 0.713 vs. 0.645 kg/d). Supplement intake (kg/animal/d) had no treatment effect (P = 0.117). On d173, forage allowance affected (P &lt; 0.01) the backfat thickness obtained by real-time carcass ultrasound (HFA = 3.08 vs. LFA = 2.85 mm). The pregnancy rate had no treatment effect (P = 0.223; on average 61%). However, the pregnant heifers per hectare had treatment effect (P = 0.036; HFA = 3.78 vs. LFA = 2.72 pregnant heifers/ha). In conclusion, the low forage allowance reduces the animal performance and affects the carcass composition but provides a greater number of pregnant heifers per hectare.

scholarly journals CD8+ T Cells Mediate Recovery andImmunopathology in West Nile VirusEncephalitis

2003 ◽  
Vol 77 (24) ◽  
pp. 13323-13334 ◽  
Author(s):  
Yang Wang ◽  
Mario Lobigs ◽  
Eva Lee ◽  
Arno Müllbacher
Keyword(s):  
T Cells ◽  
Dose Group ◽  
Low Dose ◽  
Neuronal Degeneration ◽  
High Dose ◽  
West Nile ◽  
Activation Markers ◽  
High Doses ◽  
The Brain ◽  
Deficient Mice

ABSTRACT C57BL/6J mice infected intravenously with the Sarafend strain of West Nile virus (WNV) develop a characteristic central nervous system (CNS) disease, including an acute inflammatory reaction. Dose response studies indicate two distinct kinetics of mortality. At high doses of infection (108 PFU), direct infection of the brain occurred within 24 h, resulting in 100% mortality with a 6-day mean survival time (MST), and there was minimal destruction of neural tissue. A low dose (103 PFU) of infection resulted in 27% mortality (MST, 11 days), and virus could be detected in the CNS 7 days postinfection (p.i.). Virus was present in the hypogastric lymph nodes and spleens at days 4 to 7 p.i. Histology of the brains revealed neuronal degeneration and inflammation within leptomeninges and brain parenchyma. Inflammatory cell infiltration was detectable in brains from day 4 p.i. onward in the high-dose group and from day 7 p.i. in the low-dose group, with the severity of infiltration increasing over time. The cellular infiltrates in brain consisted predominantly of CD8+, but not CD4+, T cells. CD8+ T cells in the brain and the spleen expressed the activation markers CD69 early and expressed CD25 at later time points. CD8+ T-cell-deficient mice infected with 103 PFU of WNV showed increased mortalities but prolonged MST and early infection of the CNS compared to wild-type mice. Using high doses of virus in CD8-deficient mice leads to increased survival. These results provide evidence that CD8+ T cells are involved in both recovery and immunopathology in WNV infection.

scholarly journals EFFECTS OF SLAUGHTER’ AGE ON GROWTH PERFORMANCE, CARCASS AND NON-CARCASS COMPONENTS TRAITS OF BERBER BREED LAMBS

2021 ◽  
Vol 52 (6) ◽  
pp. 1401-1407
Author(s):  
S. Atroun ◽  
C. Aissaoui ◽  
S. Smeti ◽  
N. Atti
Keyword(s):  
Body Weight ◽  
Growth Performance ◽  
Average Daily Gain ◽  
Carcass Composition ◽  
Carcass Yield ◽  
Body Weights ◽  
Slaughter Age ◽  
Daily Gain

The objective of this work was to study the lamb’s growth, the carcass yield and composition and the importance of main organs of Berber lambs slaughtered at 4 or 6 months. The study concerned 40 lambs reared under motherhood. Lambs of the first group were slaughtered at the age of 4 months (4M) and the second at 6 months (6M). Slaughter body weights (BW), hot and cold carcass weights and organs were recorded. The carcass was cut out and dissected. The average BW at birth was 4.14 + 0.506 kg while the BW at slaughter was 22.86 kg + 3.40 and 31.51 + 3.50 kg for 4M and 6M groups, respectively. The average daily gain were 172 and 164g for 4M and 6M groups, respectively. Therefore, during 2months the lambs of 6M group gained 8.67 kg in BW. The carcasses were heavier for 6M than 4M. The carcass commercial yields were 42% and 45% for 4M and 6M groups, respectively, resulting in 4.1 kg gain of meat during 2 months. The tissular (muscle, fat and bone) and the regional (leg, shoulder …) carcass composition did not differ among groups. All organs were heavier for 6M than 4M; however, their proportion in the empty body weight were variables. The BWand carcass gain at six months are encouraging to prolong the lamb’s slaughter age without carcass composition difference given the similar fat proportion in the carcass of both groups.

scholarly journals Toll-Like Receptor Signaling in Airborne Burkholderia thailandensis Infection

2009 ◽  
Vol 77 (12) ◽  
pp. 5612-5622 ◽  
Author(s):  
T. Eoin West ◽  
Thomas R. Hawn ◽  
Shawn J. Skerrett
Keyword(s):  
Low Dose ◽  
Inflammatory Responses ◽  
High Dose ◽  
Tlr Signaling ◽  
Necrosis Factor Alpha ◽  
Airborne Infection ◽  
Essential Components ◽  
High Doses

ABSTRACT Melioidosis is a tropical disease endemic in southeast Asia and northern Australia caused by the gram-negative soil saprophyte Burkholderia pseudomallei. Although infection is often systemic, the lung is frequently involved. B. thailandensis is a closely related organism that at high doses causes lethal pneumonia in mice. We examined the role of Toll-like receptors (TLRs), essential components of innate immunity, in vitro and in vivo during murine B. thailandensis pneumonia. TLR2, TLR4, and TLR5 mediate NF-κB activation by B. thailandensis in transfected HEK293 or CHO cells. In macrophages, TLR4 and the adaptor molecule MyD88, but not TLR2 or TLR5, are required for tumor necrosis factor alpha production induced by B. thailandensis. In low-dose airborne infection, TLR4 is needed for early, but not late, bacterial containment, and MyD88 is essential for control of infection and host survival. TLR2 and TLR5 are not necessary to contain low-dose infection. In high-dose airborne infection, TLR2 deficiency confers a slight survival advantage. Lung and systemic inflammatory responses are induced by low-dose inhaled B. thailandensis independently of individual TLRs or MyD88. These findings suggest that redundancy in TLR signaling or other MyD88-dependent pathways may be important in pneumonic B. thailandensis infection but that MyD88-independent mechanisms of inflammation are also activated. TLR signaling in B. thailandensis infection is substantially comparable to signaling induced by virulent B. pseudomallei. These studies provide additional insights into the host-pathogen interaction in pneumonic Burkholderia infection.

Effects of long-term continuous GnRH administration on the pituitary–gonadal axis in Eld's deer stags (Cervus eldi thamin)

1995 ◽  
Vol 73 (9) ◽  
pp. 1609-1619 ◽  
Author(s):  
S. L. Monfort ◽  
J. L. Brown ◽  
T. C. Wood ◽  
M. Bush ◽  
L. R. Williamson ◽  
...  
Keyword(s):  
Dose Group ◽  
Low Dose ◽  
High Dose ◽  
Fertile Period ◽  
Nonbreeding Season ◽  
Testosterone Secretion ◽  
High Doses ◽  
Seasonal Decline ◽  
Seasonally Breeding

Eld's deer stags (Cervus eldi thamin) (in groups of three) were continuously administered gonadotropin-releasing hormone (GnRH) in control, low, medium, or high doses (0, 20.1 ± 0.7, 83.3 ± 2.6, and 292.9 ± 4.9 ng∙kg−1∙d−1, respectively) via osmotic minipumps for ~80 d to investigate the potential for precociously reactivating the pituitary–testicular axis during the nonbreeding season. Secretory patterns of LH, FSH, and testosterone concentrations were qualitatively similar among treatments. However, in the low-dose group, basal LH and FSH concentrations were both increased (p < 0.05) and pituitary responsiveness to a superimposed GnRH challenge was augmented (p < 0.05) after 12 weeks of treatment compared with all other groups. Despite these endocrine changes, continuous low-dose GnRH administration was not effective for precociously inducing testicular activity in this seasonally breeding species. High-dose GnRH administration initially induced a transient increase in LH, FSH, and testosterone secretion and delayed, but did not prevent, the seasonal decline in spermatogenesis. After 6–12 weeks of high-dose GnRH administration, however, attenuated pituitary responsiveness appeared to delay the normal seasonal reactivation of the pituitary–gonadal axis. In conclusion, prolonged, continuous low-dose GnRH administration did not effectively translate into a precocious onset of testicular activity; therefore, this specific approach is unlikely to be useful for prolonging the fertile period in this seasonally breeding species.

Renal ammoniagenic response to chronic acid loading: role of glucocorticoids

1988 ◽  
Vol 254 (1) ◽  
pp. F134-F138 ◽  
Author(s):  
T. C. Welbourne ◽  
G. Givens ◽  
S. Joshi
Keyword(s):  
Production Rate ◽  
Low Dose ◽  
High Dose ◽  
Ammonium Excretion ◽  
Ammonia Production ◽  
Total Ammonia ◽  
High Doses ◽  
Reduced Rate ◽  
Acid Loading

Adrenalectomized (ADX) animals exhibit a blunted renal response to chronic acid loading. To determine whether this response truly reflects impaired renal ammoniagenesis from glutamine, urinary ammonium excretion was compared with acid intake in ADX, intact, and ADX rats supplemented with either a low dose (4 micrograms.100 g-1.day-1) or a high dose (40 micrograms.100 g-1.day-1) of triamcinolone. ADX rats consumed similar amounts of acid as did intact controls yet excreted only 37% of the load as ammonium; in contrast intact controls returned 86% and triamcinolone-supplemented animals returned 98 and 88% for low and high doses, respectively. Nor could the reduced ammonium excretion be attributed to increased renal venous release, since total ammonia production, the sum of renal venous and urine ammonium, was reduced to 49% of the intact controls; low- and high-dose triamcinolone restored and markedly increased the production rate. Underlying the impaired ammonia production rate in ADX rats was a reduced rate of glutamine extraction, 350 +/- 49 vs. 896 +/- 102 and 1,260 +/- 247 and 1,448 +/- 112 nmol.min-1.100 g-1 for intact and low and high doses, respectively. Unlike intact acidotic and glucocorticoid-supplemented ADX acidotic rats, glutamine extraction was disassociated from the delivered glutamine load consonant with the role of glucocorticoid in coupling cellular glutamine transport to its metabolic utilization.

Comparison of 2 growth patterns during the growing period in fattening bulls. 3. slaughter characteristics, carcass composition and meat quality

1993 ◽  
Vol 1993 ◽  
pp. 217-217
Author(s):  
A. Clinquart ◽  
C. Van Eenaeme ◽  
T. Van Vooren ◽  
J. Van Hoof ◽  
L. Istasse
Keyword(s):  
Meat Quality ◽  
Food Restriction ◽  
Early Stage ◽  
Average Daily Gain ◽  
Live Weight ◽  
Growth Patterns ◽  
Carcass Composition ◽  
Growing Period ◽  
Daily Gain

The degree to which growth patterns are modified after a period of food restriction affects the compositional changes of the carcasses(Carstens et al., 1992), furthermore, the growth rate has a direct effect on the physical properties of meat (Fishell et al., 1985). The objective of this experiment was to evaluate the effects of a severe food restriction at a early stage of maturity on the slaughter characteristics and meat quality of Belgian Blue bulls.Twelve Belgian Blue bulls (dual purpose type) weighing 233 kg were offered two different planes of nutrition during the growing period. Six bulls (Group-) received a restricted diet so that their average daily gain was 0.34 kg/d (Group+) during 202 days. By contrast six other bulls were given a more conventional growing diet and their average daily gain was 1.13 kg/d. Both Groups were fattened with similar diet and slaughtered when the live weight was close to 600 kg. Carcass weight was measured and killing-out proportion calculated, the composition of the carcass was estimated after dissection of ribs 7, 8, 9 removed 48 h post-mortem.

Pooling of Laying Hen Environmental Swabs and Efficacy of Salmonella Detection

2020 ◽  
Vol 83 (6) ◽  
pp. 943-950
Author(s):  
DEANA R. JONES ◽  
RICHARD K. GAST ◽  
PRAFULLA REGMI ◽  
GARRETT E. WARD ◽  
KENNETH E. ANDERSON ◽  
...  
Keyword(s):  
Salmonella Typhimurium ◽  
Salmonella Enteritidis ◽  
Low Dose ◽  
High Dose ◽  
Environmental Testing ◽  
Naturally Occurring ◽  
Rate Of Recovery ◽  
High Doses ◽  
The U.S ◽  
Salmonella Heidelberg

ABSTRACT Environmental testing for Salmonella Enteritidis is required for U.S. shell egg producers with ≥3,000 hens on a farm. The egg producer assumes all costs for the mandatory testing. According to the U.S. Food and Drug Administration (FDA) Egg Rule, either manure scraper or drag swabs can be collected according to published guidelines and requirements. The present study was undertaken to determine the efficacy of Salmonella detection with one-, two-, and four-swab pools of either manure scraper or drag swabs. Resistant isolates of Salmonella serovars Enteritidis (1,000 ppm of streptomycin), Heidelberg (200 ppm of nalidixic acid [NA]), Typhimurium (200 ppm of NA), and Kentucky (200 ppm of NA) were utilized. Low (approximately 8.4 CFU) and high (approximately 84 CFU) levels of inocula were introduced onto a single swab within a pool. Single flocks from each conventional cage (manure scraper swabs) and cage-free barn (drag swabs) were monitored throughout the study at the ages required under the FDA Egg Rule. The highest and most consistent recovery of inoculum was found in single swab samples. For low dose inocula, recovery of isolates was low from single manure scraper swabs (57.9 to 29.2%) and decreased as more swabs were added to the pool. Recovery of isolates from manure scraper swabs was higher for high dose inocula, although Salmonella Heidelberg was outcompeted by the naturally occurring flora and had the lowest rate of recovery among the isolates tested. One- and two-swab pools of drag swabs had similar rates of recovery at both low and high doses for Salmonella Enteritidis, Salmonella Heidelberg, and Salmonella Typhimurium. When Salmonella Enteritidis and Salmonella Kentucky were combined in an inoculum, Salmonella Enteritidis was recovered at a much higher rate than was Salmonella Kentucky for all types of swabs and doses of inocula. Pooling of two drag swabs allowed for similar detection of low and high dose Salmonella, but the pooling of manure scraper swabs decreased detection of low dose Salmonella. HIGHLIGHTS

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