IMPORTANCE OF FOLIC ACID ADMINISTERED DURING GESTATION ON HEMATOLOGICAL STATUS OF PIGLETS

1986 ◽  
Vol 66 (2) ◽  
pp. 523-527 ◽  
Author(s):  
J. J. MATTE ◽  
C. L. GIRARD ◽  
G. J. BRISSON
Keyword(s):  
Growth Rate ◽  
Folic Acid ◽  
Key Words ◽  
Serum Iron ◽  
Folic Acid Supplementation ◽  
Acid Supplementation ◽  
Newborn Piglets ◽  
Group A ◽  
Group B ◽  
Acid Administration

In a group of 88 litters (group A), 252 piglets were chosen to measure the effect of folic acid during gestation on hemoglobin (Hb), hematocrit (Ht) and liveweight of piglets at birth, 7 and 14 d after birth. Forty-three dams received 10 intramuscular injections of folic acid during gestation; 45 received no supplemental folic acid in addition to what was present in the diet. Results showed that supplemental folic acid during gestation counteracted the magnitude of the decrease in Hb [Formula: see text] and Ht [Formula: see text] during the first week after birth and tended to increase [Formula: see text] the liveweight of piglets during the second week after parturition. In an second group (group B), 131 piglets from 45 litters were used to measure the effect of folic acid supplementation during gestation on serum iron at 4 and 11 d of age. Twenty-one dams were treated with folic acid and 24 received no supplemental folic acid during gestation. Two weeks after birth, piglets liveweight tended to decrease [Formula: see text] when folic acid was administered to dams during gestation. Serum iron concentrations were similar between treatments at 4 d of age but tended to be slightly higher [Formula: see text] 11 d after birth in piglets from sows injected with folic acid during gestation. Because of the conflicting results, on growth rate, the interpretation of the effect of folic acid during gestation on piglets growth remains ambiguous. However, folic acid administration during gestation did not affect iron body reserves of newborn piglets. Key words: Sow, folic acid, gestation, anemia, piglets

scholarly journals Folic Acid Usual Doses Decrease the Buccal Micronucleus Frequency on Smokers

2019 ◽  
Vol 7 (2) ◽  
Author(s):  
Yuktiana Kharisma ◽  
Meta Maulida Damayanti ◽  
Fajar Awaliya Yulianto ◽  
Santun Bhekti Rahimah ◽  
Winni Maharani ◽  
...  
Keyword(s):  
Folic Acid ◽  
Buccal Mucosa ◽  
Folic Acid Supplementation ◽  
Wilcoxon Test ◽  
Acid Supplementation ◽  
Treatment Groups ◽  
Dna Instability ◽  
Group A ◽  
Group B ◽  
Hematoxylin Eosin

Cigarette contains toxic chemical compounds that trigger DNA instability. Initial genotoxic oral cavity characterized by the appearance of micronucleus (MN) in the buccal mucosa. Folate is needed in maintaining DNA stability. This study aimed to compare the effects of folic acid usual doses (400 mcg and 1.000 mcg) on the MN frequency of buccal mucosa in active smokers. It is a clinical trial conducted in November 2018 in the Laboratory of the Faculty of Medicine, Universitas Islam Bandung of 53 active smokers who divided into two treatment groups. Group A was administered by 400 mcg and group B 1,000 mcg folic acid supplementation within three weeks. The buccal mucosa smear stained with hematoxylin-eosin (HE) and observed through a light microscope with 100× and 400× magnification. Data were analyzed by the Wilcoxon test statistically. The results showed that there was a significant decrease (p=0.00) in MN frequency in folic acid supplementation for three weeks, namely group A=6.39±3.92 and group B=6.93±5.82 in pre-supplementation, and group A=3.80±2.66 and group B=3.31±2.71 post-supplementation of folic acid. Giving a dose of 400 mcg and 1,000 mcg for three weeks did not provide significant results (p=0.94) with Kruskal-Wallis test. In conclusion, administration of folic acid at usual dose give results to a decrease in the buccal mucosa MN frequency in active smokers. ASAM FOLAT DOSIS LAZIM MENURUNKAN FREKUENSI MIKRONUKLEUS MUKOSA BUKAL PADA PEROKOKAsap rokok mengandung senyawa kimia toksik yang memicu ketidakstabilan DNA. Deteksi genotoksik awal  rongga mulut ditandai dengan kemunculan mikronukleus (MN) pada mukosa bukal. Folat diperlukan dalam menjaga kestabilan DNA. Penelitian ini bertujuan mengetahui efek asam folat dosis lazim (400 mcg dan 1.000 mcg) terhadap frekuensi MN mukosa bukal pada perokok aktif. Penelitian ini merupakan uji klinis yang dilakukan pada bulan November 2018 di Laboratorium Fakultas Kedokteran, Universitas Islam Bandung terhadap 53 perokok aktif yang dibagi ke dalam dua kelompok perlakuan. Kelompok A mendapatkan suplementasi asam folat 400 mcg dan kelompok B mendapatkan suplementasi asam folat 1.000 mcg selama tiga pekan. Apus mukosa bukal diwarnai dengan hematoxylin-eosin (HE) dan diamati melalui mikroskop cahaya dengan pembesaran 100× dan 400x. Data dianalisis dengan uji Wilcoxon secara statistik. Hasil penelitian menunjukkan bahwa terdapat penurunan frekuensi MN yang signifikan (p=0.00) terhadap suplementasi asam folat selama tiga minggu, yaitu kelompok A=3,80±2,66 dan kelompok B=3,31±2,71 pada pre-suplementasi, serta kelompok A=6,39±3,92 dan kelompok B=6,93±5,82 pascasuplementasi asam folat. Pemberian dosis 400 mcg dan 1.000 mcg selama tiga minggu tidak memberikan hasil yang bermakna (p=0,94) berdasar atas Uji Kruskal-Wallis. Simpulan, pemberian asam folat dosis lazim memberikan hasil baik terhadap penurunan frekuensi MN mukosa bukal pada perokok aktif.

Fetal survival and conceptus development after 42 days of gestation in gilts and sows in response to folic acid supplementation

1996 ◽  
Vol 76 (1) ◽  
pp. 157-160 ◽  
Author(s):  
A. F. Harper ◽  
M. D. Lindemann ◽  
E. T. Kornegay
Keyword(s):  
Folic Acid ◽  
Key Words ◽  
Folic Acid Supplementation ◽  
Acid Supplementation ◽  
Fetal Survival ◽  
Fetal Tissues ◽  
Key Words Folic Acid ◽  
Survival And Development ◽  
Conceptus Development ◽  
Fetal Pig

The effects of feeding 2 ppm supplemental folic acid (FA) on fetal survival and development were assessed in sows (n = 32). Number of live fetuses and fetal survival at day 45 ± 3 of gestation was not influenced by FA. Fetal pig weight, length, protein and RNA content were increased (P < 0.05) with FA treatment, suggesting enhanced development of embryo/fetal tissues with maternal FA supplementation. Key words: Folic acid, gilt, sow, fetal pigs

Effects of dietary supplements of folic acid on reproductive performance in ewes

2008 ◽  
Vol 88 (3) ◽  
pp. 489-497 ◽  
Author(s):  
H. Méthot ◽  
C. L. Girard ◽  
J. J. Matte ◽  
F. W. Castonguay
Keyword(s):  
Folic Acid ◽  
Key Words ◽  
Breeding Season ◽  
Reproductive Performance ◽  
Folic Acid Supplementation ◽  
Red Cell ◽  
Folic Acid Supplement ◽  
Acid Supplementation ◽  
The One ◽  
The Impact

The objective of this project was to assess the impact of periconceptional folic acid supplementation on the reproductive performance of prolific and non-prolific ewes, in the estrous and anestrous seasons. Two initial trials took place during the estrous season at two experimental sites where 38 Dorset and 39 half-Finn half-Dorset ewes (site A) as well as 80 Dorset ewes (site C) were divided into two groups receiving either 0 or 210 mg ewe-1 d-1 of folic acid over a period which extended from 21 d premating to 30 d postmating. Three other trials were conducted in the anestrous season where 80 Dorset ewes (site A), 56 half-Romanov ewes (site B) and 78 Dorset ewes (site C) were subjected to the same protocol as the one used in the breeding season. In all the trials, the folic acid supplement increased plasma and red cell folates, but had no effect on fertility, embryonic mortality, or the size or weight of the litter at birth. Folic acid supplementation did not improve the reproductive performance of prolific and non-prolific ewes, either in the estrous season or in the anestrous period. Key words: Ewes, reproduction, vitamins, folic acid, fertility, prolificacy

Effect of maternal folic acid supplementation on hepatic proteome in newborn piglets

Nutrition ◽  
2013 ◽  
Vol 29 (1) ◽  
pp. 230-234 ◽  
Author(s):  
Jingbo Liu ◽  
Ying Yao ◽  
Bing Yu ◽  
Xiangbing Mao ◽  
Zhiqing Huang ◽  
...  
Keyword(s):  
Folic Acid ◽  
Folic Acid Supplementation ◽  
Acid Supplementation ◽  
Newborn Piglets

scholarly journals High-dose folic acid supplementation in rats: effects on gestation and the methionine cycle

2000 ◽  
Vol 83 (2) ◽  
pp. 177-183 ◽  
Author(s):  
M. Achón ◽  
E. Alonso-Aperte ◽  
L. Reyes ◽  
N. Úbeda ◽  
G. Varela-Moreiras
Keyword(s):  
Folic Acid ◽  
Dietary Supplementation ◽  
Folic Acid Supplementation ◽  
Serum Folate ◽  
Vitamin B ◽  
High Dose ◽  
Acid Supplementation ◽  
Folate Status ◽  
Methionine Cycle ◽  
Acid Administration

There is new evidence that a good folate status may play a critical role in the prevention of neural-tube defects and in lowering elevated homocysteine concentrations. This adequate folate status may be achieved through folic acid dietary supplementation. Folate is a water-soluble vitamin with a low potential toxicity. However, the possible consequences of long-term high-dose folic acid supplementation are unknown, especially those related to the methionine cycle, where folate participates as a substrate. With the aim of evaluating such possible effects, four groups of Wistar rats were classified on the basis of physiological status (virgin v. pregnant) and the experimental diet administered (folic-acid-supplemented, 40 mg/kg diet v. control, 2 mg folic acid/kg diet). Animals were fed on the diets for 3 weeks. Results showed that gestation outcome was adequate in both groups regardless of the dietary supplementation. However, there were reductions (P < 0·001) in body weight and vertex-coccyx length in fetuses from supplemented dams v. control animals. Folic acid administration also induced a higher (P < 0·01) S-adenosylmethionine : S-adenosylhomocysteine value due to increased S-adenosylmethionine synthesis (P < 0·01). However, hepatic DNA methylation and serum methionine concentrations remained unchanged. Serum homocysteine levels were reduced in supplemented dams (P < 0·05). Finally, pregnancy caused lower serum folate, vitamin B6 and vitamin B12 levels (P < 0·05). Folic acid administration prevented the effect of pregnancy and raised folate levels in dams, but did not change levels of vitamins B12 and B6. These new findings are discussed on the basis of potential benefits and risks of dietary folic acid supplementation.

Folic acid ameliorates neonatal isolation-induced autistic like behaviors in rats: Epigenetic modifications of BDNF and GFAP promotors’

2021 ◽  
Author(s):  
Omyma G. Ahmed ◽  
Ghaydaa A. Shehata ◽  
Rasha M. Ali ◽  
Rania Makboul ◽  
Eman S. H. Abd Allah ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Folic Acid ◽  
Frontal Cortex ◽  
Structural Changes ◽  
Folic Acid Supplementation ◽  
Oxidative Stress Markers ◽  
Acid Supplementation ◽  
Stress Markers ◽  
The Impact ◽  
Acid Administration

The current study investigated the role of epigenetic dysregulation of brain derived neurotrophic factor (BDNF) and glial fibrillary acidic protein (GFAP) genes and oxidative stress as possible mechanisms of autistic-like behaviors in neonatal isolation model in rats and the impact of folic acid administration on these parameters. Forty Wistar albino pups were used as follows: control, folic acid administered, isolated, and isolated folic acid treated groups. Isolated pups were separated from their mothers for 90 min daily from postnatal day (PND) 1 to 11. Pups (isolated or control) received either the vehicle or folic acid (4mg/kg/day) orally from PND 1 to 29. Behavioral tests were done from PND 30 to 35. Oxidative stress markers and antioxidant defense in the frontal cortex homogenate were determined. DNA methylation of BDNF and GFAP genes was determined by qPCR. Histopathological examination was carried out. Neonatal isolation produced autistic-like behaviors that were associated with BDNF and GFAP hypomethylation, increased oxidative stress, increased inflammatory cell infiltration, and structural changes in the frontal cortex. Folic acid administration concurrently with isolation, reduced neonatal isolation-induced autistic-like behaviors, decreased oxidative stress, regained BDNF and GFAP gene methylation, ameliorated structural changes in the frontal cortices of isolated folic acid treated rats. Novelty bullets • Neonatal isolation (NI) induces “autistic-like” behavior and these behaviors are reversed by folic acid supplementation. • Molecular and biochemical analyses showed that -NI induces DNA hypomethylation of BDNF and GFAP, increased oxidative stress markers, and neuroinflammation -All of these changes were reversed by daily folic acid supplementation.

Sign in / Sign up

Export Citation Format

Share Document