Effects of dietary supplements of folic acid on reproductive performance in ewes

2008 ◽  
Vol 88 (3) ◽  
pp. 489-497 ◽  
Author(s):  
H. Méthot ◽  
C. L. Girard ◽  
J. J. Matte ◽  
F. W. Castonguay
Keyword(s):  
Folic Acid ◽  
Key Words ◽  
Breeding Season ◽  
Reproductive Performance ◽  
Folic Acid Supplementation ◽  
Red Cell ◽  
Folic Acid Supplement ◽  
Acid Supplementation ◽  
The One ◽  
The Impact

The objective of this project was to assess the impact of periconceptional folic acid supplementation on the reproductive performance of prolific and non-prolific ewes, in the estrous and anestrous seasons. Two initial trials took place during the estrous season at two experimental sites where 38 Dorset and 39 half-Finn half-Dorset ewes (site A) as well as 80 Dorset ewes (site C) were divided into two groups receiving either 0 or 210 mg ewe-1 d-1 of folic acid over a period which extended from 21 d premating to 30 d postmating. Three other trials were conducted in the anestrous season where 80 Dorset ewes (site A), 56 half-Romanov ewes (site B) and 78 Dorset ewes (site C) were subjected to the same protocol as the one used in the breeding season. In all the trials, the folic acid supplement increased plasma and red cell folates, but had no effect on fertility, embryonic mortality, or the size or weight of the litter at birth. Folic acid supplementation did not improve the reproductive performance of prolific and non-prolific ewes, either in the estrous season or in the anestrous period. Key words: Ewes, reproduction, vitamins, folic acid, fertility, prolificacy

scholarly journals The impact of antenatal care, iron–folic acid supplementation and tetanus toxoid vaccination during pregnancy on child mortality in Bangladesh

PLoS ONE ◽  
2017 ◽  
Vol 12 (11) ◽  
pp. e0187090 ◽  
Author(s):  
Tanvir Abir ◽  
Felix Akpojene Ogbo ◽  
Garry John Stevens ◽  
Andrew Nicolas Page ◽  
Abul Hasnat Milton ◽  
...  
Keyword(s):  
Folic Acid ◽  
Antenatal Care ◽  
Child Mortality ◽  
Tetanus Toxoid ◽  
Folic Acid Supplementation ◽  
Acid Supplementation ◽  
Iron Folic Acid Supplementation ◽  
Iron Folic Acid ◽  
The Impact

scholarly journals Maternal Folic Acid Supplementation, Dietary Folate Intake and Low Birth Weight: A Birth Cohort Study

2021 ◽  
Author(s):  
LiPing Yang ◽  
Wenjuan Wang ◽  
Baohong Mao ◽  
Jie Qiu ◽  
Huaqi Guo ◽  
...  
Keyword(s):  
Folic Acid ◽  
Folic Acid Supplementation ◽  
Folate Intake ◽  
Care Hospital ◽  
Folic Acid Supplement ◽  
Dietary Folate ◽  
Acid Supplementation ◽  
Dietary Folate Intake ◽  
Reduced Risk ◽  
Joint Associations

Abstract ObjectivesTo investigate the independent and collective effects of maternal folic acid supplementation or dietary folate intake upon the risk of low birth weight (LBW), and to further comprehensively examine the joint associations of folic acid supplementation and dietary folate intake with LBW by various clinical subtypes.DesignParticipants were recruited in Gansu Provincial Maternity and Child Care Hospital. A standardized and structured questionnaire was distributed to collect demographic factors, reproductive and medical history, occupational and residential history, physical activity and diet. Data on pregnancy-related complications and birth outcomes were extracted from medical records. Unconditional logistic regression models were used to estimate odds ratio (OR) and 95% confidence interval (95%CI) for single and joint associations of folic acid supplementation and dietary folate intake with LBW. SettingA birth cohort data analysis using the 2010–2012 Gansu Provincial Maternity and Child Care Hospital in Lanzhou, China.Participants9231 pregnant women and their children were enrolled in the study. ResultsCompared to non-users, folic acid supplementation was associated with a reduced risk of LBW (OR: 0.80, 95%CI: 0.66-0.97), and the reduced risk was mainly seen for term-LBW (OR: 0.59, 95%CI: 0.41-0.85), and multiparous-LBW (OR: 0.72, 95%CI: 0.54-0.94). For dietary folate intake, there were no significant associations with LBW, and there was no interaction of folic acid supplement and dietary folate intake on LBW.ConclusionsOur study results indicated that folic acid supplementation was associated with a reduced risk of LBW, and there was not interaction of folic acid supplement and dietary folate intake on LBW.

Fetal survival and conceptus development after 42 days of gestation in gilts and sows in response to folic acid supplementation

1996 ◽  
Vol 76 (1) ◽  
pp. 157-160 ◽  
Author(s):  
A. F. Harper ◽  
M. D. Lindemann ◽  
E. T. Kornegay
Keyword(s):  
Folic Acid ◽  
Key Words ◽  
Folic Acid Supplementation ◽  
Acid Supplementation ◽  
Fetal Survival ◽  
Fetal Tissues ◽  
Key Words Folic Acid ◽  
Survival And Development ◽  
Conceptus Development ◽  
Fetal Pig

The effects of feeding 2 ppm supplemental folic acid (FA) on fetal survival and development were assessed in sows (n = 32). Number of live fetuses and fetal survival at day 45 ± 3 of gestation was not influenced by FA. Fetal pig weight, length, protein and RNA content were increased (P < 0.05) with FA treatment, suggesting enhanced development of embryo/fetal tissues with maternal FA supplementation. Key words: Folic acid, gilt, sow, fetal pigs

The impact of folate status and folic acid supplementation on the micronucleus frequency in human erythrocytes

2006 ◽  
Vol 603 (1) ◽  
pp. 33-40 ◽  
Author(s):  
Lilianne Abramsson-Zetterberg ◽  
Louise J.K. Durling ◽  
Fan Yang-Wallentin ◽  
Elisabet Rytter ◽  
Bengt Vessby
Keyword(s):  
Folic Acid ◽  
Folic Acid Supplementation ◽  
Human Erythrocytes ◽  
Acid Supplementation ◽  
Folate Status ◽  
Micronucleus Frequency ◽  
The Impact

scholarly journals Periconception folic acid supplementation, fetal growth and the risks of low birth weight and preterm birth: the Generation R Study

2009 ◽  
Vol 102 (5) ◽  
pp. 777-785 ◽  
Author(s):  
Sarah Timmermans ◽  
Vincent W. V. Jaddoe ◽  
Albert Hofman ◽  
Régine P. M. Steegers-Theunissen ◽  
Eric A. P. Steegers
Keyword(s):  
Folic Acid ◽  
Birth Weight ◽  
Preterm Birth ◽  
Low Birth Weight ◽  
The Netherlands ◽  
Fetal Growth ◽  
Late Pregnancy ◽  
Folic Acid Supplementation ◽  
Folic Acid Supplement ◽  
Acid Supplementation

Countries worldwide, including the Netherlands, recommend that women planning pregnancy use a folic acid supplement during the periconception period. Some countries even fortify staple foods with folic acid. These recommendations mainly focus on the prevention of neural tube defects, despite increasing evidence that folic acid may also influence birth weight. We examined whether periconception folic acid supplementation affects fetal growth and the risks of low birth weight, small for gestational age (SGA) and preterm birth, in the Generation R Study in Rotterdam, the Netherlands. Main outcome measures were fetal growth measured in mid- and late pregnancy by ultrasound, birth weight, SGA and preterm birth in relation to periconception folic supplementation (0·4–0·5 mg). Data on 6353 pregnancies were available. Periconception folic acid supplementation was positively associated with fetal growth. Preconception folic acid supplementation was associated with 68 g higher birth weight (95 % CI 37·2, 99·0) and 13 g higher placental weight (95 % CI 1·1, 25·5), compared to no folic acid supplementation. In these analyses parity significantly modified the effect estimates. Start of folic acid supplementation after pregnancy confirmation was associated with a reduced risk of low birth weight (OR 0·61, 95 % CI 0·40, 0·94). Similarly, reduced risks for low birth weight and SGA were observed for women who started supplementation preconceptionally, compared to those who did not use folic acid (OR 0·43, 95 % CI 0·28, 0·69 and OR 0·40, 95 % CI 0·22, 0·72). In conclusion, periconception folic acid supplementation is associated with increased fetal growth resulting in higher placental and birth weight, and decreased risks of low birth weight and SGA.

scholarly journals THE IMPACT OF FOLIC ACID SUPPLEMENTATION ON PREGNANCY

2020 ◽  
Vol 9 (5) ◽  
pp. 778-783
Author(s):  
M.MAHIMA SWAROOPA ◽  
P. SARANYA ◽  
S. SAI PREMIKA ◽  
CH. SRI VARSHA
Keyword(s):  
Folic Acid ◽  
Folic Acid Supplementation ◽  
Acid Supplementation ◽  
The Impact

Folic acid ameliorates neonatal isolation-induced autistic like behaviors in rats: Epigenetic modifications of BDNF and GFAP promotors’

2021 ◽  
Author(s):  
Omyma G. Ahmed ◽  
Ghaydaa A. Shehata ◽  
Rasha M. Ali ◽  
Rania Makboul ◽  
Eman S. H. Abd Allah ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Folic Acid ◽  
Frontal Cortex ◽  
Structural Changes ◽  
Folic Acid Supplementation ◽  
Oxidative Stress Markers ◽  
Acid Supplementation ◽  
Stress Markers ◽  
The Impact ◽  
Acid Administration

The current study investigated the role of epigenetic dysregulation of brain derived neurotrophic factor (BDNF) and glial fibrillary acidic protein (GFAP) genes and oxidative stress as possible mechanisms of autistic-like behaviors in neonatal isolation model in rats and the impact of folic acid administration on these parameters. Forty Wistar albino pups were used as follows: control, folic acid administered, isolated, and isolated folic acid treated groups. Isolated pups were separated from their mothers for 90 min daily from postnatal day (PND) 1 to 11. Pups (isolated or control) received either the vehicle or folic acid (4mg/kg/day) orally from PND 1 to 29. Behavioral tests were done from PND 30 to 35. Oxidative stress markers and antioxidant defense in the frontal cortex homogenate were determined. DNA methylation of BDNF and GFAP genes was determined by qPCR. Histopathological examination was carried out. Neonatal isolation produced autistic-like behaviors that were associated with BDNF and GFAP hypomethylation, increased oxidative stress, increased inflammatory cell infiltration, and structural changes in the frontal cortex. Folic acid administration concurrently with isolation, reduced neonatal isolation-induced autistic-like behaviors, decreased oxidative stress, regained BDNF and GFAP gene methylation, ameliorated structural changes in the frontal cortices of isolated folic acid treated rats. Novelty bullets • Neonatal isolation (NI) induces “autistic-like” behavior and these behaviors are reversed by folic acid supplementation. • Molecular and biochemical analyses showed that -NI induces DNA hypomethylation of BDNF and GFAP, increased oxidative stress markers, and neuroinflammation -All of these changes were reversed by daily folic acid supplementation.

Folic Acid Supplementation in Low Birth Weight Infants

PEDIATRICS ◽  
1979 ◽  
Vol 64 (3) ◽  
pp. 333-335 ◽  
Author(s):  
David Stevens ◽  
David Burman ◽  
M. Keith Strelling ◽  
Audrey Morris
Keyword(s):  
Folic Acid ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Acid Group ◽  
Folic Acid Supplementation ◽  
Folate Intake ◽  
Red Cell ◽  
Low Birth Weight Infants ◽  
Acid Supplementation ◽  
Significant Difference

Low birth weight infants(246) entered a trial of folic acid supplementation from 3 weeks to 12 months of age. The folic acid group had significantly higher mean hemoglobin levels at 6 and 9 months of age but the differences were only about 0.5 gm/dl, there was no significant difference in hematocrit, and in both groups of infants the mean hemoglobin levels were higher than those of normal birth weight infants. The differences in hemoglobin, although statistically significant, are of uncertain clinical significance. Median red cell folate levels remained within the normal adult range in both groups of infants. A minority of infants in the untreated group had low red cell folate levels but this was usually temporary, corrected by dietary folate, and not associated with low hemoglobin. Weight gain was not affected by folic acid supplementation. The infants in this trial were fed with a milk preparation containing 3.5 µg/100 ml of folic acid which is a similar concentration to that of human milk and we recommend that the folate content of milks fed to low birth weight infants should not fall below this level. We do not have sufficient grounds to recommend routine folic acid supplements for all low birth weight infants throughout the first year of life but there is a possibility that their folate intake may sometimes be suboptimal.

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