A METHOD FOR ASSESSING THE NUTRITIONAL STATUS OF GESTATING EWES

1983 ◽  
Vol 63 (3) ◽  
pp. 603-611 ◽  
Author(s):  
G. P. LYNCH ◽  
C. JACKSON Jr.
Keyword(s):  
Fatty Acids ◽  
Nutritional Status ◽  
Feed Intake ◽  
Crude Protein ◽  
Ketone Bodies ◽  
Total Serum Protein ◽  
Total Serum ◽  
Restricted Feeding ◽  
Nonesterified Fatty Acids ◽  
Limiting Nutrient

The purpose of this study was to identify metabolic changes that occur at low feed intake in order to develop a method to predict the nutritional status of gestating ewes carrying single or multiple fetuses. At about the 5th week of gestation, 32 ewes were assigned equally into treatments of free choice and restricted intakes of chopped orchardgrass hay. The initial intake of each restricted ewe was determined by calculating ration amounts to supply 60% of the NRC crude protein allowance. Feed intake of each ewe was increased weekly to 80 and then to 100% of NRC crude protein allowance according to changes in the metabolites studied. Plasma citrate and nonesterified fatty acids were increased during gestation, but 3-hydroxybutyrate showed the greatest potential for indicating nutritional status of the gestating ewe. Urinary ketones appeared during the 15th week of gestation and in about one-half of the ewes on restricted intake by the 17th week of gestation. At this point, plasma 3-hydroxybutyrate was 0.53 μmol/mL and might indicate a value at which intake adjustment is needed. Total serum protein and blood urea nitrogen (BUN) were decreased by the 20th week of gestation by the ewes fed restricted intakes indicating an effect of restricted feeding on protein metabolism. Increases in both plasma β-hydroxybutyrate and urine ketone bodies by restricted feeding indicated that energy was an early limiting nutrient and that these metabolites may be useful as indicators of nutritional status. Key words: Gestating ewes, predicting nutritional requirements, citrate, nonesterified fatty acids, 3-hydroxybutyrate

EFFECTS OF VARYING DIETARY ENERGY, PROTEIN AND AMINO ACID LEVELS ON GROWTH, NUTRIENT DIGESTIBILITY, AND SERUM PROTEIN LEVELS OF EARLY WEANED PIGS

1967 ◽  
Vol 47 (1) ◽  
pp. 77-83 ◽  
Author(s):  
J. F. Standish ◽  
J. P. Bowland
Keyword(s):  
Amino Acid ◽  
Serum Protein ◽  
Feed Intake ◽  
Crude Protein ◽  
Feed Utilization ◽  
Nutrient Digestibility ◽  
Total Serum Protein ◽  
Total Serum ◽  
Or Efficiency ◽  
Protein Levels

Fifteen rations formulated by a factorial arrangement of 3 fat and 5 protein treatments were fed to non-castrate crossbred pigs from 3 to 9 weeks of age. Levels of 0, 4, and 8% fat and 12, 16, and 20% crude protein, and 12 and 16% crude protein with supplemental lysine and methionine to equal that present in the 20% protein diet were fed. Each increment of protein resulted in increased rate of gain. The amino acid supplemented 16% protein ration supported as rapid gain and as efficient utilization of feed as did the 20% ration. Feed intake and efficiency of feed utilization were improved as protein was raised from 12 to 16% and when lysine and methionine were added to the rations. Fat levels were not found to affect rate of gain, feed intake or efficiency of feed utilization. Apparent digestibility of nitrogen was higher in the 20% protein ration than the 12 or 16% protein rations and was also found to increase when amino acids were added to the low protein rations. More of the apparent digestible nitrogen was retained from the amino acid-supplemented rations. Increasing fat levels were found to reduce: the total serum protein levels in gilts but not in boars.

scholarly journals Effects of 3-hydroxybutyrate and free fatty acids on muscle protein kinetics and signaling during LPS-induced inflammation in humans: anticatabolic impact of ketone bodies

2018 ◽  
Vol 108 (4) ◽  
pp. 857-867 ◽  
Author(s):  
Henrik H Thomsen ◽  
Nikolaj Rittig ◽  
Mogens Johannsen ◽  
Andreas B Møller ◽  
Jens Otto Jørgensen ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Acute Inflammation ◽  
Ketone Bodies ◽  
Muscle Protein ◽  
Initiation Factor ◽  
Whole Body ◽  
Protein Breakdown ◽  
Protein Kinetics ◽  
Nonesterified Fatty Acids

Abstract Background Acute inflammation, and subsequent release of bacterial products (e.g. LPS), inflammatory cytokines, and stress hormones, is catabolic, and the loss of lean body mass predicts morbidity and mortality. Lipid intermediates may reduce protein loss, but the roles of free fatty acids (FFAs) and ketone bodies during acute inflammation are unclear. Objective We aimed to test whether infusions of 3-hydroxybutyrate (3OHB), FFAs, and saline reduce protein catabolism during exposure to LPS and Acipimox (to restrict and control endogenous lipolysis). Design A total of 10 healthy male subjects were randomly tested 3 times, with: 1) LPS, Acipimox (Olbetam) and saline, 2) LPS, Acipimox, and nonesterified fatty acids (Intralipid), and 3) LPS, Acipimox, and 3OHB, during a 5-h basal period and a 2-h hyperinsulinemic, euglycemic clamp. Labeled phenylalanine, tyrosine, and urea tracers were used to estimate protein kinetics, and muscle biopsies were taken for Western blot analysis of protein metabolic signaling. Results 3OHB infusion increased 3OHB concentrations (P < 0.0005) to 3.5 mM and decreased whole-body phenylalanine-to-tyrosine degradation. Basal and insulin-stimulated net forearm phenylalanine release decreased by >70% (P < 0.005), with both appearance and phenylalanine disappearance being profoundly decreased. Phosphorylation of eukaryotic initiation factor 2α at Ser51 was increased in skeletal muscle, and S6 kinase phosphorylation at Ser235/236 tended (P = 0.074) to be decreased with 3OHB infusion (suggesting inhibition of protein synthesis), whereas no detectable effects were seen on markers of protein breakdown. Lipid infusion did not affect phenylalanine kinetics, and insulin sensitivity was unaffected by interventions. Conclusion During acute inflammation, 3OHB has potent anticatabolic actions in muscle and at the whole-body level; in muscle, reduction of protein breakdown overrides inhibition of synthesis. This trial was registered at clinicaltrials.gov as NCT01752348.

Nutritional status and intake regulation in sheep. V. Effects of intraruminal infusions of volatile fatty acids upon voluntary intake of roughage by sheep

1966 ◽  
Vol 17 (5) ◽  
pp. 741 ◽  
Author(s):  
AR Egan
Keyword(s):  
Fatty Acids ◽  
Acetic Acid ◽  
Energy Balance ◽  
Nutritional Status ◽  
Propionic Acid ◽  
Feed Intake ◽  
Volatile Fatty Acids ◽  
Voluntary Intake ◽  
Induced Changes ◽  
Intake Regulation

Results of experiments with infusions of volatile fatty acids into the rumen reveal that the induced changes in voluntary intake of roughages are not immediate, and vary in extent between animals. Single infusions resulted in subsequent depressions of feed intake, these being only partly related to the amount of energy of the infused volatile fatty acids. When longer-term infusions were made, acetic acid in small quantities depressed feed intake more than did propionic, and propionic acid modified the effect of acetic when the two were given together. Also recorded is an observation that animals receiving a casein-supplemented roughage diet reduced their feed intake when casein was infused per duodenum over 14-day periods. Results are discussed in relation to an hypothesis of an indirect mechanism attempting to maintain or restore the original energy balance, but showing considerable delay or inertia and imprecision when observed on a day to day basis.

Persistence of metabolic rhythmicity during fasting and its entrainment by restricted feeding schedules in rats

1998 ◽  
Vol 274 (5) ◽  
pp. R1309-R1316 ◽  
Author(s):  
Carolina Escobar ◽  
Mauricio Díaz-Muñoz ◽  
Fabiola Encinas ◽  
Raúl Aguilar-Roblero
Keyword(s):  
Fatty Acids ◽  
Lipid Metabolism ◽  
Free Fatty Acids ◽  
Ketone Bodies ◽  
Liver Glycogen ◽  
Restricted Feeding ◽  
Feeding Schedule ◽  
Daily Food ◽  
Catabolic State

The presence of a food-entrainable oscillator (FEO) independent from the SCN is now well established, but until now its location and characterization have been elusive. Because its expression requires priming of the animal’s metabolism toward a catabolic state, it is possible that metabolic rhythms may be related to FEO. The present study was designed to determine whether metabolic rhythms persist during fasting and whether such rhythms could be entrained to a restricted feeding schedule. The results indicate persistent rhythms of triacylglycerides, free fatty acids, glucose, and proteins during fasting, whereas ketone bodies and liver glycogen changed their concentration as a function of fasting. Daily food pulses of 2 h entrained the rhythms of triacylglycerides and free fatty acids and restored ketone bodies and liver glycogen to similar levels as controls. Neither glucose nor proteins were affected by the food pulse. These results indicate the relevance of lipid metabolism as a phenomenon associated with the FEO.

Variation of plasma ketones and free fatty acids during acute cold exposure in man

1965 ◽  
Vol 20 (1) ◽  
pp. 56-60 ◽  
Author(s):  
Peter G. Hanson ◽  
Robert E. Johnson
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Cold Exposure ◽  
Ketone Bodies ◽  
Control Period ◽  
Exposure Period ◽  
Nonesterified Fatty Acids ◽  
Acute Cold Exposure ◽  
Plasma Ffa ◽  
And Control

We have studied the magnitude of ketosis induced during acute cold exposure. Plasma and urinary ketone bodies and plasma free fatty acids (FFA) were followed in four healthy young men at rest during a 90-min period of seminude exposure to 0 C in still air. This period was followed by 4 hr of recovery at 25 C. Each subject served as his own control throughout an experimental sequence in which one cold-exposure and corresponding control period (25 C) were experienced each week for 3 successive weeks. The subjects were in a fasting state but with water ad libitum beginning 12 hr prior to the experiment. Light weight clothing was worn during recovery and control periods. The combined group data show a significant increase in plasma FFA during cold exposure as compared with similar control periods. Although true hyperketonemia or hyperketonuria did not develop, the levels of plasma ketones are elevated in the cold-exposure period of the first week. During the second and third week there is no difference between the cold and control plasma ketone concentration. The data suggest that FFA is mobilized as a metabolic substrate during cold exposure and that efficient peripheral utilization of the elevated plasma FFA concentration minimizes hyperketogenesis. ketone bodies; metabolism; nonesterified fatty acids Submitted on April 27, 1964

Nutritional status of patients with acquired immunodeficiency syndrome.

1988 ◽  
Vol 34 (10) ◽  
pp. 1957-1959 ◽  
Author(s):  
C M Huang ◽  
M Ruddel ◽  
R J Elin
Keyword(s):  
Nutritional Status ◽  
Binding Protein ◽  
Morbidity And Mortality ◽  
Retinol Binding Protein ◽  
Total Serum Protein ◽  
Total Serum ◽  
Hiv Positive ◽  
Normal Individuals ◽  
Significant Difference ◽  
Immunodeficiency Syndrome

Abstract Nutritional status may be an important factor in the prognosis of morbidity and mortality. We assessed the nutritional status of individuals seropositive for human immunodeficiency virus (HIV) (as confirmed by Western blot) and of patients with AIDS, by determining the concentration in serum of total protein, albumin, prealbumin (transthyretin), and retinol-binding protein. HIV-seropositive individuals showed no significant difference from normal volunteers in values for prealbumin, albumin, and retinol-binding protein. Patients with AIDS showed significantly smaller prealbumin and albumin concentrations than did normal and HIV-positive individuals. There was no significant difference in the concentration of retinol-binding protein among the three groups. The concentration of total serum protein was significantly greater in HIV-positive individuals and in patients with AIDS than in normal individuals. Thus, the nutritional status of patients with AIDS may be a factor for morbidity and mortality.

scholarly journals Nonesterified Fatty Acids and Hospitalizations Among Older Adults: The Cardiovascular Health Study

2020 ◽  
Author(s):  
Peter D Ahiawodzi ◽  
Petra Buzkova ◽  
Luc Djousse ◽  
Joachim H Ix ◽  
Jorge R Kizer ◽  
...  
Keyword(s):  
Older Adults ◽  
Fatty Acids ◽  
Cardiovascular Health ◽  
Proportional Hazards ◽  
Clinic Visit ◽  
Cox Proportional Hazards ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Total Serum ◽  
Nonesterified Fatty Acids

Abstract Background We sought to determine associations between total serum concentrations of nonesterified fatty acids (NEFAs) and incident total and cause-specific hospitalizations in a community-living cohort of older adults. Methods We included 4715 participants in the Cardiovascular Health Study who had fasting total serum NEFA measured at the 1992/1993 clinic visit and were followed for a median of 12 years. We identified all inpatient admissions requiring at least an overnight hospitalization and used primary diagnostic codes to categorize cause-specific hospitalizations. We used Cox proportional hazards regression models to determine associations with time-to-first hospitalization and Poisson regression for the rate ratios (RRs) of hospitalizations and days hospitalized. Results We identified 21 339 hospitalizations during follow-up. In fully adjusted models, higher total NEFAs were significantly associated with higher risk of incident hospitalization (hazard ratio [HR] per SD [0.2 mEq/L] = 1.07, 95% confidence interval [CI] = 1.03–1.10, p &lt; .001), number of hospitalizations (RR per SD = 1.04, 95% CI = 1.01–1.07, p = .01), and total number of days hospitalized (RR per SD = 1.06, 95% CI = 1.01–1.10, p = .01). Among hospitalization subtypes, higher NEFA was associated with higher likelihood of mental, neurologic, respiratory, and musculoskeletal causes of hospitalization. Among specific causes of hospitalization, higher NEFA was associated with diabetes, pneumonia, and gastrointestinal hemorrhage. Conclusions Higher fasting total serum NEFAs are associated with a broad array of causes of hospitalization among older adults. While some of these were expected, our results illustrate a possible utility of NEFAs as biomarkers for risk of hospitalization, and total days hospitalized, in older adults. Further research is needed to determine whether interventions based on NEFAs might be feasible.

Nutritional Status of Korean Peritoneal Dialysis Patients

1999 ◽  
Vol 19 (2_suppl) ◽  
pp. 517-523 ◽  
Author(s):  
Sung Hee Chung ◽  
Myung Hee Na ◽  
Sui Hyung Lee ◽  
Sung Ja Park ◽  
Won Seck Chu ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Nutritional Status ◽  
Body Mass ◽  
University Hospital ◽  
Stepwise Multiple Regression ◽  
Severe Malnutrition ◽  
Total Serum Protein ◽  
Total Serum ◽  
Western Literature

Objectives To assess the nutritional status of Korean peritoneal dialysis (PD) patients and to compare with data from Western literature, and to elucidate independent factors determining nutritional status and death. Design Cross-sectional single-center study. Setting Kidney Center, Soon Chun Hyang University Hospital. Materials Ninety-eight CAPD patients were included. Of these, 54 patients were male, 32 patients were diabetic, mean age was 47.9 :i: 13.1 years, and mean duration of CAPD was 22.3 :i: 21.6 months. The patients were followed until death, transfer to hemodialysis (HD) or other units, transplantation, or until 3 years had elapsed after the first evaluation. Methods Nutritional status was assessed by subjective global assessment (SGA), biochemical and anthropometric measurements, fat-free edema-free (FFEF) body mass by creatinine (Cr) kinetics, protein equivalent of total nitrogen appearance (PNA), and urea kinetic studies. Results By SGA score, 53.1% of patients were classified as normal, 44.9% with mild-to-moderate malnutrition, and 2% with severe malnutrition. Patients with malnutrition were significantly older and had higher peritonitis rates, lower serum albumin (Alb), blood urea nitrogen (BUN), serum Cr, FFEF body mass, mid arm muscle circumference, and PNA (p < 0.05). On stepwise multiple regression analysis, the SGA score was negatively correlated with age and peritonitis rate (p < 0.01). At the end of the 3-year follow-up period, 11 patients were still on CAPD, 26 had died, 51 had transferred to HD and 5 to other units, 3 patients had been transplanted, and 2 patients were lost to follow-up. Patients who died during follow-up were older and had higher peritonitis rates and lower total serum protein, Alb, Cr, and FFEF body mass when compared to those who survived (p < 0.05). Independent predictors of death were age, peritonitis rate, and serum Alb (p < 0.01). Conclusion Malnutrition was as common in Korean PD patients as reported in the Western literature. Our data suggests that, to prevent malnutrition and early death, it is important to reduce the peritonitis rate, to improve protein intake, and to prescribe an adequate dose of peritoneal dialysis.

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