SERUM GROWTH HORMONE CONCENTRATION IN HEREFORD AND ANGUS CALVES: EFFECTS OF BREED, SIRE, SEX, AGE, AGE OF DAM, AND DIET

1979 ◽  
Vol 59 (2) ◽  
pp. 367-373 ◽  
Author(s):  
D. G. KELLER ◽  
G. H. COULTER ◽  
V. G. SMITH ◽  
G. J. KING
Keyword(s):  
Growth Hormone ◽  
Body Weight ◽  
Beef Cattle ◽  
Hormone Concentration ◽  
Serum Growth Hormone ◽  
Blood Samples ◽  
Selection Program ◽  
Performance Traits ◽  
Serum Gh ◽  
Sampling Times

Serum growth hormone (GH) concentrations were determined in 172 Hereford and 172 Angus bull and heifer calves before weaning and while restricted to the feedlot for 5.5 mo and fed either an 80% concentrate plus 20% roughage or roughage only diet. Blood samples were taken 1 mo before weaning (27 Sept.; T1), 2 mo into the feedlot period (5 Jan.; T2), and 5 mo into the feedlot period (5 Apr.; T3). GH concentrations and ratios of GH to body weight were greater in Angus than in Hereford at all sampling times. GH levels were higher in bulls than heifers 1 mo before weaning and at 5 mo into the feedlot period. However, the ratio of GH to body weight was higher in bulls than heifers only at 1 mo before weaning. The heritability estimates (h2) for GH and GH/100 kg body weight were generally low. The h2 of GH concentration 1 mo before weaning was 0.16 ± 0.13. Calves at 5 mo of age (T1) tended to have higher serum GH concentrations than at 8 (T2) or 11 (T3) mo of age. Age of dam and plane of nutrition had little effect on GH concentrations or its ratio with body weight in the calves, but had various degrees of influence on the performance traits. Correlations among GH and GH/100 kg body weight estimates with performance traits were also generally low. GH levels at the three sampling times that corresponded to 5, 8, and 11 mo of age in young beef bulls and heifers in this study will, apparently, not be a reliable indicator or predictor of the performance of a particular animal in a beef cattle selection program.

Serum somatotropin concentrations in Holstein heifers administered growth hormone-releasing factor and somatostatin

1998 ◽  
Vol 66 (3) ◽  
pp. 551-556 ◽  
Author(s):  
G. W. Kazmer ◽  
S. A. Zinn
Keyword(s):  
Growth Hormone ◽  
Body Weight ◽  
Early Identification ◽  
Response Curve ◽  
Dairy Calves ◽  
Production Traits ◽  
Individual Animal ◽  
Milk Production Traits ◽  
Serum Growth Hormone ◽  
Blood Samples

AbstractDose-response experiments were designed to determine the dosage of somatostatin (SRIF) necessary to alter serum growth hormone (GH) response to administration of GH-releasing factor (1·44; GRF) in cattle. The objective of this experimentation was to develop a GRF/SRIF challenge model that might be useful in early identification of animals which are genetically superior for milk production traits. In experiment 1, calves received either 0, 5 or 10 /JLg GRF per 100 kg body weight (BW) or GRF 1·29 at 1 ug per 100 kg BW. Both the 5 and 10 ug GRF per 100 kg BW dosages increased GH concentrations (P < 0·05). In experiment 2, animals received 3 ug GRF per 100 kg BW concurrent with administration of 0, 0·5, 1 or 2 ug SRIF per 100 kg BW at 0 min, with second dosage of GRF at +120 min. Administration of SRIF in those dosages did not alter GH response to GRF. In experiment 3, animals received 5 ug SRIF per 100 kg BW at -2, -1, 0 or +1 min relative to 3 ug GRF per 100 kg BW, with a second GRF injection at +120 min. No differences (P < 0·05) were found in response due to timing of SRIF administration. In experiment 4, animals were administered 0, 5, 10 or 20 Xg SRIF per 100 kg BW concurrent with 3 ug GRF per 100 kg BW. SRIF delayed (P < 0·05) the occurrence of maximum GH concentrations but did not affect the maximum concentration nor the area under the GH response curve (AUC) following either the first or second GRF injection. Utilizing data from experiment 4, individual animal response to GRF was reasonably consistent, as repeatabilities of AUCs for 1 h following first and second GRF injections were 0·80 and 0·65, respectively. Furthermore, sufficient among-animal variation existed so that animals could be distinguished from each other. Thus we conclude the method described herein might be useful in identifying superior dairy calves but accuracy would potentially be enhanced by collecting blood samples more frequently during the 20 min immediately after GRF injection.

Reproductive and lactational responses and serum growth hormone and insulin in fine-wool ewes treated with ovine growth hormone

1988 ◽  
Vol 46 (2) ◽  
pp. 195-202 ◽  
Author(s):  
D. W. Holcombe ◽  
D. M. Hallford ◽  
W. C. Hoefler
Keyword(s):  
Growth Hormone ◽  
Food Intake ◽  
Milk Production ◽  
Milk Fat ◽  
Serum Insulin ◽  
Post Partum ◽  
Serum Growth Hormone ◽  
Blood Samples ◽  
Treatment Groups ◽  
Serum Gh

AbstractEighteen mature (3 to 6 years) Debouillet × Rambouillet ewes (mean weight 79·2 (s.e. 21) kg) producing and nursing single offspring were randomly allotted to one of three groups to examine the influence of ovine growth hormone (oGH) on reproductive, hormonal and lactational responses of springlambing ewes. Each ewe received a daily subcutaneous injection of either 0, 5 or 10 mg oGH from day 11 through to day 20 post partum (day 0 = parturition). Treatment groups were subdivided into two pens (three ewes per pen) and food intake was monitored from day 1 through to day 20 post partum. On days 11 and 20 post partum, jugular blood samples were collected before and hourly for 8 h after treatment. Blood samples were also collected daily from day 10 through to day 21 post partum and on alternate days through to day 40 post partum. Milk production (oxytocin-induced hand milking) and fat and protein concentrations were determined 21 days post partum. Food intake did not differ before or during the treatment period (P > 0·05). Likewise, ewe and lamb weights were similar among treatment groups through to day 60 post partum (P > 0·05). Serum insulin did not differ before or after treatment on day 11 (P > 0·05); however, on day 20 before treatment, serum insulin was significantly higher in ewes receiving 5 (2·3 (s.e. 0·3) μg/I) and 10 (2·4 (s.e. 0·3) μg/1) mg oGH than in controls (1·2 (s.e. 0·3) μg/1) (P < 0·05). After treatment, no differences were detected in serum insulin among treatments on day 20 post partum (P > 0·05). Serum growth hormone (GH) was similar among groups before treatment on day 11 post partum; but by 8 h after treatment, serum GH was significantly elevated in ewes receiving 10 mg oGH (32·4 (s.e. 1·9) μg/1) compared with ewes receiving 5 (13·9 (s.e. 1·9) μg/1) or 0 (4·5 (s.e. 1·9) μg/1) mg oGH (P < 0·01). By 20 days after lambing, serum GH differed significantly among groups both before and after administration of exogenous oGH (P < 0·01). Ewes receiving 5 or 10 mg oGH produced 2·3 (s.e. 0·2) kg milk per day compared with 1·9 (s.e. 0·2) kg/day for controls (P < 0·10). Milk fat and protein concentrations did not differ significantly among treatments (P > 0·05), but total fat yield was higher in ewes receiving either dose of oGH (206 (s.e. 20) g/day) compared with control ewes (141 (s.e. 20) g/day) (P < 005). Serum progesterone remained less than 0·5 μg/1 in ewes through to day 40 post partum. A linear decrease was observed in interval from parturition to first observed oestrus as dosage of oGH increased (116, 108 and 102 (s.e. 6) days for ewes receiving 0, 5 and 10 mg oGH, respectively; P = 0·10). Administration of exogenous oGH to lactating. anoestrous ewes between days 11 and 20 post partum enhances milk production and may influence the interval to oestrus.

Effects of refeeding of undernourished and insulin treatment of diabetic neonatal rats on IGF and IGFBP

1996 ◽  
Vol 271 (2) ◽  
pp. E223-E231 ◽  
Author(s):  
L. Goya ◽  
F. Rivero ◽  
M. A. Martin ◽  
R. Arahuetes ◽  
E. R. Hernandez ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Body Weight ◽  
Growth Factor ◽  
Mrna Expression ◽  
Insulin Treatment ◽  
Diabetic Rats ◽  
Insulin Like Growth Factor ◽  
Neonatal Rats ◽  
Igf I ◽  
Serum Gh

The effect of refeeding and insulin treatment of undernourished and diabetic neonatal rats, respectively, on the regulation of insulin-like growth factor (IGF) and insulin-like growth factor binding protein (IGFBP) was investigated. The changes in body weight, insulinemia, glycemia, serum IGF-I, and growth hormone (GH) as well as the increase of the 30-kDa IGFBP in undernourished and diabetic neonatal rats previously shown elsewhere were reversed by refeeding and insulin treatment, respectively. Also, changes in liver mRNA expression of IGF-I and-II and IGFBP-1 and -2 were restored in refed undernourished and IGF-I and IGFBP-1 levels recovered in insulin-treated diabetic rats. However, serum GH was still below normal after rehabilitation in both situations. Thus the present results support the idea of a GH-independent IGF/ IGFBP regulation mediated by a balance of insulin and nutrients as has already been suggested in previous neonatal studies.

Cytostatics for acromegaly

1987 ◽  
Vol 116 (3) ◽  
pp. 347-349 ◽  
Author(s):  
A. A. Kasperlik-Zaluska ◽  
J. Wislawski ◽  
J. Kaniewska ◽  
J. Zborzil ◽  
E. Frankiewicz ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Visual Field ◽  
Ct Scan ◽  
Tumour Growth ◽  
Pituitary Tumour ◽  
Hormone Concentration ◽  
Serum Growth Hormone ◽  
X Ray ◽  
Transcranial Approach ◽  
Symptoms And Signs

Abstract. A 21-year-old woman suffering from acromegaly was treated with transsphenoidal subtotal hypophysectomy (microscopy: acidophilic adenoma), followed by x-ray and bromocriptine therapy. Seven years later she was re-operated because of a partial bitemporal loss of vision, intracranial hypertension, and regrowth of the pituitary tumour seen on CT-scan. A large part of the invasive suprasellar tumour was then removed by transcranial approach. The neurosurgery was followed by cobalt radiotherapy and bromocriptine administration. Two years later, symptoms and signs of tumour growth reappeared. Administration of cytostatics, such as doxorubicin (Adriamycin®) and lomustine (Belustine®), resulted in distinct clinical improvement associated with a seven-fold decrease in the serum growth hormone concentration. The visual field became normal and the intracranial mass on a CT scan decreased markedly. As a result the patient was able to resume work.

Endocrine changes and their relationship with body weight in growing yaks

2002 ◽  
Vol 74 (1) ◽  
pp. 89-94
Author(s):  
Tian Yongqiang ◽  
Zhao Xingxu ◽  
Wang Minqiang ◽  
Lu Zhonglin ◽  
Zhang Rongchang
Keyword(s):  
Growth Hormone ◽  
Body Weight ◽  
Seasonal Change ◽  
Seasonal Changes ◽  
Significant Positive Correlation ◽  
The Body ◽  
Nutrition Status ◽  
Blood Samples ◽  
Different Seasons ◽  
Grass Growth

AbstractThe concentrations of growth hormone (GH), insulin (Ins), tri-iodothyronine (T3) and thyroxine (T4) in blood samples of growing yaks during different bimonthly seasons were determined by radioimmunoassay. The changes of body weight of growing yaks and composition of grass grazed were measured accordingly. The seasonal changes of hormones were significant (P < 0·01 or P < 0·05). Within season, the variances of hormones depended upon the different growing stages. The body-weight gains in the different groups varied in different seasons, increase being significant in May, July and September, decrease being significant from January to May. Correlation analysis indicated that T4 concentration had a significant positive correlation with the body weight of the growing yaks(r = 0·2509, P < 0·05) and other hormones did not have any significant correlation with body weight. The results showed that the annual cycle of weight loss and gain was attributed to the seasonal change of nutrition status. The seasonal change of the assayed hormones depended on the grass growth.

The influence of dietary monensin and salinomycin on growth and endocrine status of gilts

1992 ◽  
Vol 72 (2) ◽  
pp. 427-429 ◽  
Author(s):  
T. A. Van Lunen ◽  
R. N. Kirkwood ◽  
P. A. Thacker
Keyword(s):  
Growth Hormone ◽  
Body Weight ◽  
Key Words ◽  
Crude Protein ◽  
Protein Diet ◽  
Serum Growth Hormone ◽  
Endocrine Status ◽  
Effect Of Treatment

Seventy-two gilts were fed a 16% crude protein diet supplemented with monensin, salinomycin or not supplemented. There was no effect of treatment on gilt growth between 30 and 100 kg body weight. Monensin-fed gilts tended to have increased, while salinomycin-fed gilts had decreased (P < 0.01), serum growth hormone concentrations. Salinomycin-fed gilts were older and heavier at puberty (P < 0.05). Key words: Monensin, salinomycin, gilts, growth, reproduction

Effect of Chlorpromazine on Serum Growth-Hormone Concentration in Man

1971 ◽  
Vol 284 (2) ◽  
pp. 72-74 ◽  
Author(s):  
Lawrence Sherman ◽  
Sooseng Kim ◽  
Fred Benjamin ◽  
Howard D. Kolodny
Keyword(s):  
Growth Hormone ◽  
Hormone Concentration ◽  
Serum Growth Hormone ◽  
Growth Hormone Concentration ◽  
Serum Growth Hormone Concentration

Growth hormone response to growth hormone-releasing hormone in normal and uraemic children. Comparison with hypoglycaemia following insulin administration

1987 ◽  
Vol 114 (1) ◽  
pp. 5-11 ◽  
Author(s):  
D. Bessarione ◽  
F. Perfumo ◽  
M. Giusti ◽  
F. Ginevri ◽  
G. Mazzocchi ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Body Weight ◽  
Adverse Effects ◽  
Significant Variation ◽  
Growth Hormone Releasing Hormone ◽  
Blood Samples ◽  
Releasing Hormone ◽  
Uraemic Children ◽  
Insulin Test ◽  
Peak Value

Abstract. The uraemic syndrome is characterized by several endocrinological disturbances. This study was undertaken in order to evaluate the GH response to growth hormone-releasing hormone (GRH) in children with chronic renal failure (CRF) and to compare the results with those observed after insulin hypoglycaemia. Twenty-two children with CRF, 10 undergoing continuous ambulatory peritoneal dialysis (CAPD) and 12 on conservative treatment (CT), age ranges 2–15 years, were studied and the data were compared with those from 14 children with normal renal function and normal hormonal behaviour, affected by short stature (NC), and those form 13 healthy adult volunteers (NA). The GRH test (1 μg/kg body weight, iv) was carried out in 8 CAPD, 8 CT, 9 NC and 10 NA subjects. The blood samples were taken every 30 min for 3 h in CAPD and CT and for 2 h in NC and NA starting at 09.00 h. The following hormones were measured: GH, LH, FSH, Prl, TSH and cortisol (F). The insulin test (0.1 U/kg body weight, iv) was carried out in 5 CAPD, 5 CT, 10 NC and 9 NA on blood samples taken every 30 min for 2 h, measuring GH and glycaemia. No adverse effects were observed after the infusion of GRH. GRH administration induced a prompt response in all subjects, but GH plasma levels were significantly higher in uraemic children than in adults (peak value of 43.5 ± 8.2, 45.0 ± 8.4, 27.8 ± 6.0; 13.5 ± 2.6 μg/ml in CAPD, CT, NC and NA, respectively). The secretory areas were significantly narrower in NC (P < 0.05) and NA (P < 0.01) than in CAPD, and in NA than in CT (P < 0.01). The GH response to insulin did not differ in the 4 groups. The secretory area in CAPD and CT was wider after GRH than after insulin. The GH peak value of CAPD and NC was significantly higher after GRH than following insulin. No significant variation in TSH, LH and FSH was observed after the infusion of the neuropeptide, whereas Prl and F showed a reduction. The behaviour of Prl and F in NA and NC was similar after placebo and GRH. Our data show: a) There is a greater response of GH to GRH in children than in adults; b) compared with the insulin test, GRH stimulation seems to be a reliable means of evaluating GH secretion both in normal and uraemic children owing to the absence of qualitatively different responses and to the freedom from the adverse effects or risks which follow insulin infusion; c) GRH administration does not induce any significant variation on other hypophyseal hormones and the reduction of Prl and F seems to follow the normal sleep-wake and circadian behaviour.

THE INFLUENCE OF GROWTH HORMONE TREATMENT ON THYROID FUNCTION IN SWINE

1990 ◽  
Vol 70 (3) ◽  
pp. 991-995 ◽  
Author(s):  
R. N. KIRKWOOD ◽  
P. A. THACKER ◽  
B. LAARVELD
Keyword(s):  
Growth Hormone ◽  
Body Weight ◽  
Key Words ◽  
Growth Hormone Treatment ◽  
Sampling Period ◽  
Hormone Treatment ◽  
Serum Concentrations ◽  
Significant Treatment ◽  
Blood Samples ◽  
To Receive

Twelve castrated male pigs of Yorkshire and Landrace breeding were selected at 95.9 ± 1.6 kg body weight (BW) and allocated equally to receive daily injections of either porcine growth hormone (pGH) at 90 μg kg−1 BW or vehicle buffer for four consecutive days. Following the last pGH injection, the pigs were infused via indwelling vena caval cannulae with thyrotropin-releasing hormone (TRH) at 0.5 μg kg−1 BW. Blood samples were obtained at 10 and 0 min before TRH and thereafter at 10-min intervals for 90 min. Serum concentrations of thyroxine and thyrotropin were lower (P < 0.06 and P < 0.1, respectively) but those of triiodothyronine higher (P < 0.01) in pGH-treated pigs throughout the sampling period. There were no significant treatment-by-time interactions indicating that the thyroid response to TRH was not influenced by pGH treatment. Key words: Swine, thyroid, growth hormone, somatotropin

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