THE INFLUENCE OF GROWTH HORMONE TREATMENT ON THYROID FUNCTION IN SWINE

1990 ◽  
Vol 70 (3) ◽  
pp. 991-995 ◽  
Author(s):  
R. N. KIRKWOOD ◽  
P. A. THACKER ◽  
B. LAARVELD
Keyword(s):  
Growth Hormone ◽  
Body Weight ◽  
Key Words ◽  
Growth Hormone Treatment ◽  
Sampling Period ◽  
Hormone Treatment ◽  
Serum Concentrations ◽  
Significant Treatment ◽  
Blood Samples ◽  
To Receive

Twelve castrated male pigs of Yorkshire and Landrace breeding were selected at 95.9 ± 1.6 kg body weight (BW) and allocated equally to receive daily injections of either porcine growth hormone (pGH) at 90 μg kg−1 BW or vehicle buffer for four consecutive days. Following the last pGH injection, the pigs were infused via indwelling vena caval cannulae with thyrotropin-releasing hormone (TRH) at 0.5 μg kg−1 BW. Blood samples were obtained at 10 and 0 min before TRH and thereafter at 10-min intervals for 90 min. Serum concentrations of thyroxine and thyrotropin were lower (P < 0.06 and P < 0.1, respectively) but those of triiodothyronine higher (P < 0.01) in pGH-treated pigs throughout the sampling period. There were no significant treatment-by-time interactions indicating that the thyroid response to TRH was not influenced by pGH treatment. Key words: Swine, thyroid, growth hormone, somatotropin

THE INFLUENCE OF EXOGENOUS GROWTH HORMONE ON ENDOCRINE STATUS AND THE OVULATORY RESPONSE TO PMSG IN PREPUBERTAL GILTS

1990 ◽  
Vol 70 (1) ◽  
pp. 309-312 ◽  
Author(s):  
R. N. KIRKWOOD ◽  
P. A. THACKER ◽  
R. S. KORCHINSKI ◽  
B. LAARVELD
Keyword(s):  
Growth Hormone ◽  
Key Words ◽  
Jugular Vein ◽  
Serum Concentrations ◽  
Blood Samples ◽  
Exogenous Growth ◽  
Endocrine Status ◽  
The Difference ◽  
To Receive ◽  
Surge Height

Twenty-three prepubertal Yorkshire × Landrace gilts were allocated to receive daily injections of either porcine growth hormone (pGH) or vehicle for 6 consecutive days. At the time of first pGH or buffer injection, all gilts received an injection of 500 IU PMSG. Blood samples were taken by jugular vein puncture at 0, 24 and 48 h then every 12 h until 96 h then every 8 h until 144 h. Samples were assayed for triiodothyronine (T3), insulin, glucose and LH. Treatment with pGH elevated (P < 0.01) serum concentrations of T3, insulin and glucose, and was associated with a reduced (P < 0.05) LH surge height. Fewer pGH-treated than vehicle-treated gilts ovulated (4/12 vs. 7/11), but the difference was not significant. Key words: Gilts, growth hormone, gonadotrophins, ovulation

scholarly journals The response of the hepatic insulin-like growth factor system to growth hormone and dexamethasone in calves

2003 ◽  
Vol 179 (3) ◽  
pp. 427-435 ◽  
Author(s):  
HM Hammon ◽  
Y Zbinden ◽  
H Sauerwein ◽  
BH Breier ◽  
JW Blum ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Body Weight ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Postnatal Growth ◽  
Mrna Levels ◽  
Plasma Growth Hormone ◽  
Somatotropic Axis ◽  
Igf I ◽  
Igfbp 3

Glucocorticoids inhibit postnatal growth and yet can stimulate the somatotropic axis around birth. The aim of the present study was to investigate the effects of dexamethasone on the somatotropic axis and on the responses of the insulin-like growth factor (IGF) system to growth hormone treatment in calves. Calves (n=24) were randomly divided into four groups. Group DX was injected with dexamethasone (30 micro g/kg body weight per day), group GH was injected with 500 mg slow-release bovine growth hormone at 14-day intervals, group GHDX was injected with dexamethasone and bovine growth hormone, and group CNTRL (serving as control) was injected with saline from day 3 to day 42 of life. Blood samples were taken on day 3 and blood and liver samples were obtained on days 7, 14, 28 and 42. Body weight increased in the CNTRL and GH groups up to the end of the study and in the DX and GHDX groups up to the fourth week. Dexamethasone treatment decreased (P<0.05) plasma IGF binding protein (IGFBP)-1 on days 7 and 14, but increased (P<0.05) plasma IGFBP-1, decreased (P<0.05) plasma IGF-I and IGFBP-3, and decreased hepatic mRNA for growth hormone receptor (GHR) and IGF-I on day 42. Growth hormone treatment increased (P<0.05) plasma growth hormone concentrations on days 7 and 14, tended to increase (P<0.1) plasma IGF-I concentrations on day 42, and increased (P<0.05) hepatic mRNA levels of GHR on day 14 and IGF-I mRNA levels on days 7 and 14. The combined dexamethasone and growth hormone treatment increased plasma growth hormone concentrations on day 7 and resulted in the highest plasma concentrations of IGF-I and IGFBP-3 (day 7 to day 28) as well as the greatest abundance of hepatic GHR (day 14) and IGF-I (days 7 and 14) mRNA. Plasma IGFBP-1 concentrations in the GHDX group behaved in a similar manner as in the DX group. In conclusion, the response of the somatotropic axis to growth hormone treatment could be greatly enhanced by dexamethasone treatment during the neonatal and early postnatal period, but body weight gain was not improved. Dexamethasone alone inhibited the somatotropic axis and postnatal growth after the first Month of life.

Effect of glucocorticoid and growth hormone treatment on proinsulin levels in humans

Diabetes ◽  
1993 ◽  
Vol 42 (7) ◽  
pp. 1082-1085 ◽  
Author(s):  
S. E. Kahn ◽  
F. F. Horber ◽  
R. L. Prigeon ◽  
M. W. Haymond ◽  
D. Porte
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Treatment ◽  
Hormone Treatment

scholarly journals Patient preferences for growth hormone treatment in Japanese children

2021 ◽  
Author(s):  
Toshiaki Tanaka ◽  
Takahiro Sato ◽  
Akira Yuasa Mhwm ◽  
Takeshi Akiyama ◽  
Adeeb Tawseef
Keyword(s):  
Growth Hormone ◽  
Patient Preferences ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Japanese Children
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