scholarly journals GROWTH DEPRESSING FACTORS IN RAPESEED OILMEAL.: IV. COMPARATIVE FEEDING VALUES OF ARGENTINE AND POLISH TYPES AND THE EFFECTS OF SUPPLEMENTARY AUREOMYCIN, FISHMEAL, LYSINE, IODIDE AND THYROID-ACTIVE SUBSTANCES

1957 ◽  
Vol 37 (1) ◽  
pp. 43-49
Author(s):  
J. M. Bell
Keyword(s):  
Factorial Design ◽  
Room Temperature ◽  
Allyl Isothiocyanate ◽  
Calcium Stearate ◽  
Protein Supplement ◽  
Male Mice ◽  
Commercial Mixture ◽  
Active Substances

Two experiments were carried out to compare the feeding values of oilmeals derived from Argentine and Polish types of rape. In the first, four rapeseed oilmeal samples were used: (1) new oilmeal representing a commercial mixture of approximately equal parts of both types; (2) old oilmeal, predominantly of Argentine type and which had been stored five years at room temperature in a porous container; (3) Argentine type, and (4) Polish type. According to a factorial design, each oilmeal was tested as either the entire protein supplement, in a 25 per cent protein ration, or as half the supplement along with either linseed oilmeal or skimmilk powder. As cross treatments with each of these 12 rations the following were tested: (1) nil; (2) 0.01 per cent iodinated casein; (3) 20 p.p.m. aureomycin, and (4) iodinated casein plus aureomycin.In the second experiment, three ’goitrogenic’ basal diets were used: (1) soybean oilmeal and linseed oilmeal with 0.15 per cent dl-5-vinyl-2-thiooxazolidone; (2) Argentine rapeseed oilmeal, and (3) Polish rapeseed oilmeal. Three subtreatments were superimposed on each of these: (1) nil; (2) 5 per cent fishmeal, and (3) 0.5 per cent dl-lysine. Cross-treatments of (1) nil, (2)0.02 per cent iodinated casein, (3) 0.0002 percent sodium 1-thyroxine, and (4) 0.014 per cent iodine as KI-calcium stearate were also investigated.The tests involved 252 male mice with records on their gains and individual feed intakes.No marked differences were found between kinds of rapeseed oilmeal. The Argentine and Polish types had 0.4 and 0.3 per cent allyl isothiocyanate equivalent, respectively. Neither linseed oilmeal, skimmilk powder, fishmeal nor lysine proved beneficial at the levels of rapeseed oilmeal tested, but the latter two modified the response to thyroid supplements.Iodinated casein, thyroxine and iodide were likewise ineffective against the growth-depressing factor in rapeseed oilmeal. These findings are discussed in relation to apparently opposing results from other investigators.

scholarly journals Influence of Emollient on the Preparation and stability of Sodiun Ascorbyl Phospate Cream

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Yanni Dhiani Mardhiani ◽  
Deny Puriyani Azhari ◽  
Silviana Wulansari
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Room Temperature ◽  
Antioxidant Activities ◽  
Skin Barrier ◽  
Penetration Enhancer ◽  
Isopropyl Myristate ◽  
Topical Formulation ◽  
Diffusion Test ◽  
Active Substances

As a type of cosmetic preparation products, cream dosage form is widely used with the addition of active substances having antioxidant activities, such as vitamin C and its derivatives. Sodium ascorbyl phosphate (SAP) can be used in topical formulation due to its more stable properties than ascorbic acid. However, it is difficult to deliver SAP into the dermis in a suficient dose. To overcome the problem, occasionally we can add a penetration enhancer. In some literature, emollients that often added in cosmetic preparations also have another effect as a penetration enhancer. The purpose of this research was to observe wether emollient addition could influence the penetration of SAP in the cream formulation or not. SAP was formulated into four formulations with three different emollients: dimethicone (F1), capric triglyceride (F2), and isopropyl myristate (F3) and a formulation without the addition of emollients (F4). The diffusion test was performed by Franz's diffusion cell method using male wistar rat’s abdominal membrane as a standard model of the skin barrier. The result of stability test showed that SAP cream was stable at room temperature but unstable on freeze thaw condition described by significant different values for all formulas. Nonetheless, the diffusion test showed that F2 with the capric triglyceride as emollient had the highest ability to pass SAP through the membrane, followed by isopropyl miristate. We concluded that emollient addition could influence the penetration of the cream of SAP.Keywords: vitamin c, ascorbic acid, sodium ascorbyl phospate, emollient, penetration enhancer

scholarly journals Pengaruh Madu Terhadap Hepar Mencit yang Terpapar Asap

2020 ◽  
Vol 12 (2) ◽  
pp. 1017-1022
Author(s):  
Muhammad Yusha Akbar
Keyword(s):  
Oxidative Stress ◽  
Cigarette Smoke ◽  
Phenolic Antioxidants ◽  
Control Group ◽  
Test Results ◽  
Male Mice ◽  
Food Ingredient ◽  
Post Test ◽  
The Common ◽  
Active Substances

Honey is a human food ingredient produced by bees. Honey is a special food ingredient and has high nutritional value, honey has been proven to be used as a burn medicine and as an antioxidant. More specifically and honey can be used to prevent liver damage due to obstruction of the common bile duct and due to cysticercus cysts in the liver. Honey is known to contain organic acids, minerals, vitamins, and is rich in active substances that act as antioxidants that can protect the liver from damage. Research also confirms that the phenolic antioxidants present in honey are very effective, thus increasing the body's resistance to fighting oxidative stress. Cigarette smoke contains 4000 types of organic substances and cigarette smoke can become free radicals that can cause oxidative stress and damage normal tissue. The method used in this study was true experimental with a post-test only controlled group design. Using  30 male mice, the results obtained were that the provision of honey had an effect on the microscopic image of the liver of male mice exposed to cigarette smoke, but the statistical test results did not show any significant differences between the control group and the treatment group. Further research is needed with different dose variations.

scholarly journals Topical antifungal bigels: Formulation, characterization and evaluation

2018 ◽  
Vol 68 (2) ◽  
pp. 223-233 ◽  
Author(s):  
Agne Mazurkeviciute ◽  
Kristina Ramanauskiene ◽  
Marija Ivaskiene ◽  
Aidas Grigonis ◽  
Vitalis Briedis
Keyword(s):  
Room Temperature ◽  
Liquid Paraffin ◽  
Poloxamer 407 ◽  
Microsporum Canis ◽  
Test Results ◽  
Ciclopirox Olamine ◽  
Terbinafine Hydrochloride ◽  
Antifungal Substances ◽  
Active Substances ◽  
Great Inhibition

Abstract Bigels with antifungal substances, ciclopirox olamine and terbinafine hydrochloride, were made of hydrogel (poloxamer 407 gel) and oleogel (polyethylene and liquid paraffin mixture). Prepared bigels were found physically stable at room temperature for six months and at least four months at 40 °C. Released amount of drug decreased when oleogel concentration in the formulation increased. Release test results depended on the insertion place of active substances. The amount of released substance was highest when ciclopirox olamine was incorporated in both phases in an equal quantity, and terbinafine hydrochloride in oleogel or in hydrogel. All formulations showed great inhibition of Microsporum canis. Thus, bigels with ciclopirox olamine and terbinafine hydrochloride are a promising dosage form for topical use.

scholarly journals Lipid Nanoparticles Loaded with Iridoid Glycosides: Development and Optimization Using Experimental Factorial Design

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3161
Author(s):  
Marta Dąbrowska ◽  
Eliana B. Souto ◽  
Izabela Nowak
Keyword(s):  
Factorial Design ◽  
Iridoid Glycosides ◽  
Lipid Nanoparticles ◽  
Stability Study ◽  
Lipid Matrix ◽  
32 Factorial Design ◽  
Nanometer Size Range ◽  
Optimization Of Composition ◽  
Active Substances

Lipid nanoparticles based on multiple emulsion (W/O/W) systems are suitable for incorporating hydrophilic active substances, including iridoid glycosides. This study involved optimization of composition of lipid nanoparticles, incorporation of active compounds (aucubin and catalpol), evaluation of stability of the resulting nanocarriers, and characterization of their lipid matrix. Based on 32 factorial design, an optimized dispersion of lipid nanoparticles (solid lipid:surfactant—4.5:1.0 wt.%) was developed, predisposed for the incorporation of iridoid glycosides by emulsification-sonication method. The encapsulation efficiency of the active substances was determined at nearly 90% (aucubin) and 77% (catalpol). Regarding the stability study, room temperature was found to be the most suitable for maintaining the expected physicochemical parameter values (particle size < 100 nm; polydispersity index < 0.3; zeta potential > |± 30 mV|). Characterization of the lipid matrix confirmed the nanometer size range of the resulting carriers (below 100 nm), as well as the presence of the lipid in the stable β’ form.

scholarly journals Antioxidative Effect of Sage (Salvia officinalis L.) Macerate as “Green Extract” in Inhibiting the Oxidation of Fish Oil

Antioxidants ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 100
Author(s):  
Agnieszka M. Hrebień-Filisińska ◽  
Artur Bartkowiak
Keyword(s):  
Fish Oil ◽  
Room Temperature ◽  
Sensory Quality ◽  
Antioxidant Properties ◽  
Carnosic Acid ◽  
Refrigerated Storage ◽  
Antioxidative Effect ◽  
Salvia Officinalis L ◽  
Active Substances ◽  
Temperature Storage

The aim of the study was to assess the antioxidant effect of concentrated oil macerate of sage (M) as a “green extract” in inhibiting the oxidation of Fish Oil (FO). In the homogenization-assisted maceration process, FO was used as a solvent for the sage active substances to produce M, which was then added to FO (25% w/w) and evaluated for its effect by monitoring the level of oxidation during refrigerated and room temperature storage. The macerate also examined polyphenols, plant pigments, DPPH antioxidant potential, oxidation level and sensory quality. It was shown that the maceration process made it possible to obtain aromatized M, containing polyphenols (carnosic acid, carnosol) and pigments, but with an increased level of peroxides, free fatty acids, compared to the control oil. M showed antioxidant properties and inhibited FO oxidation. It showed the best efficiency in FO during refrigerated storage, in the third month it reduced the level of peroxides by about 9 times, compared to the control. M retains unchanged quality at refrigerated temperature for up to 3 months. Sage macerates are „green extracts” that can be used as effective natural antioxidant additives, following preparation improvements to reduce the amount of peroxide formed.

WETTING POWER IN CALCIUM-SOAP–OIL SYSTEMS

1944 ◽  
Vol 22b (6) ◽  
pp. 155-160
Author(s):  
Wilfred Gallay ◽  
Ira E. Puddington
Keyword(s):  
Room Temperature ◽  
Contact Angles ◽  
Calcium Stearate ◽  
Calcium Soap ◽  
Mineral Oils ◽  
Special Means ◽  
Wetting Power ◽  
Water Glycerol ◽  
Sedimentation Volume ◽  
Measured Water

Contact angles of various mineral oils and water on relatively polar and non-polar calcium stearate surfaces prepared by special means were measured. Pre-moistening of the soap surface with small quantities of water decreased the subsequent contact angle against oil. The effect of the polarity of the oil was determined, and the action of water in the system is discussed.The sedimentation volume of calcium stearate in mineral oil, with and without various added materials, was measured. Water, glycerol, and alcohol effected an agglomeration of the suspended soap, and less polar liquids had no effect. Fatty acid in small quantities brought about a swelling of the soap at room temperature. The relation between wetting power and sedimentation volume is discussed.

scholarly journals Development of the Composition and Technology of New Neuroprotective Drug Tablets Using Fractional Factorial Design

2020 ◽  
Vol 9 (1) ◽  
pp. 18-22
Author(s):  
O. A. Terenteva ◽  
E. V. Flisyuk ◽  
D. Yu. Ivkin ◽  
I. A. Narkevich
Keyword(s):  
Factorial Design ◽  
Fractional Factorial Design ◽  
Desirability Function ◽  
Neuroprotective Effect ◽  
Compressibility Factor ◽  
Fractional Factorial ◽  
Calcium Stearate ◽  
Technological Properties ◽  
Maize Starch

Introduction. The creating an effective and safe domestic neuroprotective medicines with a complex of pleiotropic effects realized through specific orphan receptors (SUCNR1, HCA2) of glial cells, is a pressing problem of modern pharmacology and a promising possibility of pharmacotherapy of brain injury and cerebrovascular diseases. Ideally, the medicine should helps restore lost cognitive functions and physical performance after damage to the central nervous system, and its use should improve the quality of life of patients and reduce the risk of complications.Aim. To develop composition and technology of a new medicine tablets with neuroprotective effect, using fractional factorial design of experiment and the Harrington desirability function.Materials and methods. The shape and size of particles, physicochemical (solubility, melting point) and technological properties (bulk density, compressibility factor, fractional composition, hygroscopicity) of the pharmaceutical substance of DEAE derivative were studied according to the methods described in the State Pharmacopoeia of the Russian Federation (14th edition). A three-factor fractional plan based on the 4 × 4 Latin square design for selection a scientifically based composition of solid dosage form was chosen. 16 experiments to test the significance of the factors were carried out. The tablets obtained according to the planning matrix were investigated for disintegration; tablet crush resistance, friability, and hygroscopicity. To optimize the quality of the tablets, the generalized Harrington desirability function was used.Results and discussion. The study of the physicochemical and technological properties of the DEAE derivative substance showed that it is a highly hygroscopic, amorphous, white or pale yellow, odourless powder, prone to the formation of agglomerates. The powder is very easily soluble in water. Taking into account the values of the general desirability function, the best result was shown by sample № 4 consisting of mannitol, calcium stearate, and partially pregelatinized maize starch.Conclusion. The physicochemical and technological properties of the DEAE derivative were studied. The DEAE derivative is a highly hygroscopic substance. Via the method of mathematical planning of the experiment the composition of DEAE derivative tablets was selected and scientifically grounded: DEAE derivative 60 mg, mannitol, partially pregelatinized maize starch, calcium stearate. The average tablet weight is 300 mg. The parameters of pressing tablets were selected.

scholarly journals Kualitas Telur Puyuh Selama Penyimpanan dan Temperatur yang Berbeda

2020 ◽  
Vol 10 (1) ◽  
pp. 70
Author(s):  
Rizki Arizona ◽  
Abdul Rahman Ollong
Keyword(s):  
Weight Loss ◽  
Factorial Design ◽  
Cell Size ◽  
Room Temperature ◽  
Storage Time ◽  
Shape Index ◽  
Refrigerated Storage ◽  
Significant Difference ◽  
The Impact

The objective of this study is to determine the quality of quail eggs stored at room temperature and refrigerated. The variables evaluated are weight loss, shape index, air cell size, and the height of both the albumen and the yolk. Several factors, such as storage time and temperature could affect the quality of quail eggs. Therefore, we investigated the impact of both factors. The samples used for this experiment include 360 quail eggs. This research uses a completely randomized factorial design with two treatments. The treatments consisted of storage time (0, 7, 14, and 21 days) and temperature (room temperature and refrigerator). Each treatment was replicated 9 times. Analyses of variance had been applied to analyze the data and followed with Duncan’s test to see whether there was a significant difference between treatments. The result showed that storage time and temperature have significant effects on weight loss of the eggs, air cell size, and albumen and yolk height. The interaction between treatments had a significant impact on air cell size and yolk height. Refrigerated storage for 21 days showed the best result.

By Using FE-Fe2O3 Galvanic Pair in Sulphate Solution for Obtaining of a Chemical Source of a Current

2014 ◽  
Vol 1033-1034 ◽  
pp. 170-172
Author(s):  
Z.M. Mussina ◽  
A.B. Bayeshov ◽  
M.Zh. Zhurynov ◽  
G. Toktar
Keyword(s):  
Iron Oxide ◽  
Electromotive Force ◽  
Room Temperature ◽  
Water Solution ◽  
External Loading ◽  
Electrochemical System ◽  
Iron Sulphates ◽  
The Given ◽  
Active Substances ◽  
A Current

In this article was given the results of research of electrochemical system on a basis of iron and iron oxide (Fe2O3) which can be used for obtaining of a chemical source of a current (CSC). Use of the given system does not suggest the application of expensive and ecologically harmful active substances. Electromotive force of a source of a current it was investigated in a water solution of iron sulphates, at a room temperature, in absence of external loading.

Dependence of Intergranular Fracture on Boundary Topography and Cohesion

1973 ◽  
Vol 31 ◽  
pp. 150-151
Author(s):  
J. E. Doherty ◽  
A. F. Giamei ◽  
B. H. Kear ◽  
C. W. Steinke
Keyword(s):  
Grain Boundary ◽  
Room Temperature ◽  
Nickel Base Superalloy ◽  
Boundary Shear ◽  
Room Temperature Ductility ◽  
Solid Solution Matrix ◽  
Nickel Base ◽  
Solution Matrix ◽  
Different Levels ◽  
Base Superalloy

Recently we have been investigating a class of nickel-base superalloys which possess substantial room temperature ductility. This improvement in ductility is directly related to improvements in grain boundary strength due to increased boundary cohesion through control of detrimental impurities and improved boundary shear strength by controlled grain boundary micros true tures.For these investigations an experimental nickel-base superalloy was doped with different levels of sulphur impurity. The micros tructure after a heat treatment of 1360°C for 2 hr, 1200°C for 16 hr consists of coherent precipitates of γ’ Ni3(Al,X) in a nickel solid solution matrix.

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