scholarly journals Reproductive performance and uterine prostaglandin secretion in gilts conditioned with dead semen and receiving dietary supplements of folic acid

2000 ◽  
Vol 80 (3) ◽  
pp. 467-472 ◽  
Author(s):  
A. Giguère ◽  
C. L. Girard ◽  
R. Lambert ◽  
J. P. Laforest ◽  
J. J. Matte
Keyword(s):  
Folic Acid ◽  
Dietary Supplements ◽  
Reproductive Performance ◽  
Allantoic Fluid ◽  
Estrus Cycle ◽  
Folate Supplementation ◽  
Folate Status ◽  
Litter Weight ◽  
Key Words Folic Acid ◽  
Folic Acid Supplements

The effects of dietary supplements of folic acid at 0 (F−) or 15 ppm (F+) and of conditioning the uterus (C+) or not (C−) with an intrauterine infusion of dead semen on embryonic survival and prostaglandin E2 (PGE2) concentrations in the allantoic fluid on day 30 of gestation were studied. Sixty-four F1 crossbred gilts (Yorkshire × Landrace) were used in a 2 × 2 factorial design. The initiation of folate supplementation and the intrauterine infusion of dead semen were done at the estrus preceding the fertile mating. Folate status in serum was lower in F+ gilts than in F− gilts during the estrus cycle (folic acid × period interaction, P ≤ 0.007). Conditioning increased ovulation rate in F− gilts while it tended to decrease it in F+ gilts (interaction folic acid × conditioning, P ≤ 0.03). A similar interaction (P ≤ 0.02) was observed on the number of presumably live embryos at 30 d of gestation. Mean PGE2 concentration in the allantoic fluid was not affected by treatments (P ≥ 0.44), but the frequency of sows having elevated allantoic PGE2 (> 4 ng mL−1) tended to be higher (P ≤ 0.06) in F+ sows. Overall values of PGE2 were correlated with total litter weight (R2 = 0.54). In conclusion, there was no synergism between folic acid supplements and conditioning of the uterus with dead semen on the reproductive performance or on the secretion of allantoic PGE2 at 30 d of gestation. The secretion of allantoic PGE2 appears as an important factor involved in the control of litter size and weight. Key words: Folic acid, artificial insemination, semen, gilts, conditioning, embryo mortality

scholarly journals Folic Acid Fortification and Women’s Folate Levels in Selected Communities in Brazil - A First Look

2014 ◽  
Vol 84 (5-6) ◽  
pp. 286-294 ◽  
Author(s):  
Hrishikesh Chakraborty ◽  
Kwame A. Nyarko ◽  
Norman Goco ◽  
Janet Moore ◽  
Danilo Moretti-Ferreira ◽  
...  
Keyword(s):  
Folic Acid ◽  
Folate Intake ◽  
Serum Folate ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Folate Supplementation ◽  
Folic Acid Fortification ◽  
Folic Acid Supplements ◽  
Two Samples ◽  
Reproductive Aged Women

Abstract. Background: Several countries have implemented mandatory folic acid fortification of wheat flour and selected grain products to increase the folate intake of reproductive-aged women. Brazil implemented a folic acid fortification program in 2004. No previous studies have examined folate differences among Brazilian women following the mandate. Objective: We evaluate differences in serum and red blood cell (RBC) folate concentrations between two samples of women of childbearing age from selective communities in Brazil, one tested before (N = 116) and the other after the mandate (N = 240). Methods: We compared the baseline folate levels of women enrolled in a prevention study shortly before the fortification mandate was implemented, to baseline levels of women from the same communities enrolled in the same study shortly after fortification began. The participants were women enrolled in a folate supplementation clinical trial, at a hospital specializing in treating craniofacial anomalies in the city of Bauru from January 29, 2004 to April 27, 2005. We only compared baseline folate levels before the women received oral cleft prevention program (OCPP) folic acid supplements. Results: Women enrolled after the fortification mandate had higher means of serum folate (20.3 versus 11.2 nmol/L; p < 0.001) and RBC folate (368.3 versus 177.6 nmol/L; p < 0.001) than women enrolled before the mandate. Differences in folate levels between the two groups remained after adjusting for several co-variables. Conclusions: The results suggest that serum and RBC folate levels among women of childbearing age increased after implementing the folic acid fortification mandate in Brazil.

Folate Status Assessment and Folic Acid Supplements in Sickle Cell Disease

2001 ◽  
Vol 23 (8) ◽  
pp. 548 ◽  
Author(s):  
J. B. Schnog ◽  
F. P. L. van der Dijs ◽  
M. R. Fokkema ◽  
F. D. Muskiet ◽  
F. A. J. Muskiet
Keyword(s):  
Folic Acid ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cell Disease ◽  
Folate Status ◽  
Folic Acid Supplements ◽  
Status Assessment

Pre- and post-mating dietary supplements of folic acid and uterine secretory activity in gilts

1997 ◽  
Vol 77 (3) ◽  
pp. 415-420 ◽  
Author(s):  
J. Duquette ◽  
J. J. Matte ◽  
C. FarMer ◽  
C. L. Girard ◽  
J. -P. Laforest
Keyword(s):  
Folic Acid ◽  
Dietary Supplements ◽  
Culture Medium ◽  
Secretory Activity ◽  
Uterine Tissue ◽  
Key Words Folic Acid ◽  
Uterine Secretions ◽  
The Impact ◽  
Sow Reproduction ◽  
Estradiol 17Β

The present study was carried out to determine the effects of pre- and (or) post-mating dietary supplements of folic acid on uterine secretions and secretory activity on day 12 of gestation. Crossbred gilts were assigned randomly to three treatments: SS) a dietary supplement of 15 mg of folic acid kg−1 of diet from the estrus before mating (approximately day –21) until day 12 of gestation (n = 9), 0S) the same folic acid supplement from mating (day 0) to day 12 of gestation (n = 10), and 00) no supplement of folic acid (n = 10). At slaughter (day 12 of gestation), one uterine horn was flushed with 20 mL of PBS to collect embryos and uterine flushings, while samples of uterine tissue were collected from the other horn. Supplementary folic acid (0S and SS) increased total folates in uterine flushings (P ≤ 0.05) as well as concentrations of folates in the endometrium (P ≤ 0.0004) and in the whole uterine tissue (endometrium + myometrium: P ≤ 0.0001). Total amounts of prostaglandin (PG)E2 and PGF2α in uterine flushings were not affected (P ≥ 0.8) by any treatment but estradiol-17β was numerically 40% lower (P ≥ 0.12) in uterine flushings of 0S and SS sows. Samples of endometrium (15–17 mg) were cultured for 2 to 7 h. Concentrations of PGE2 and PGF2α in the culture medium increased with the duration of incubation (P ≤ 0.0001) but there was no treatment effect (P ≥ 0.4). The inconsistency between the folic acid response seen in the present study and in previous results using multiparous sows suggests that the impact of this vitamin on sow reproduction might be linked to the parity (and/or prolificacy) of the animal. Key words: Folic acid, uterine tissue, secretion, prostaglandins, gilts

Serum clearance and urinary excretion of folic acid in milk-fed and weaned calves

1997 ◽  
Vol 77 (1) ◽  
pp. 69-75 ◽  
Author(s):  
C. L. Girard ◽  
J. J. Matte
Keyword(s):  
Folic Acid ◽  
Urinary Excretion ◽  
Folic Acid Supplementation ◽  
Short Term ◽  
Folate Status ◽  
Serum Clearance ◽  
Key Words Folic Acid ◽  
Erythrocyte Concentration ◽  
Milk Replacers

Thirty male calves were assigned to treatments in a 2 × 3 factorial experiment in which the diet (exclusively milk replacers or dry feed) and the duration of the period of folic acid supplementation (no, short-term, i.e., 7 d before each period of evaluation of the folate status, or long-term supplementation, i.e., throughout the experiment) were the two main factors. During their first 4 mo of life, the folate status of calves was evaluated monthly. In milk-fed calves, erythrocyte concentration of folates increased with the duration of the supplementation (P = 0.008) but it decreased with age (P = 0.01). In weaned calves, it was similar for calves receiving no or a short-term supplementation but it was higher for those receiving the long-term supplementation and the decrease with age was more marked with this last treatment (supplementation × age, P = 0.01). Serum clearance of an i.v. bolus of folic acid was similar for milk-fed and weaned calves (P = 0.2), it was more rapid with age (P = 0.02), but it slowed down with the duration of the supplementation (P = 0.05). The percentage of the dose of folic acid injected i.m. recovered in urine was higher in milk-fed than in weaned calves (P = 0.0001) and it decreased with age (P = 0.0001). The present results suggest that the tissue demand for folic acid is high in preruminant and ruminant calves and it increases during the first 4 mo of life. Key words: Folic acid, serum clearance, urinary excretion, milk-fed calf, weaned calf

scholarly journals Folic Acid From Supplements or Fortified Foods Consumed During Pregnancy and/or Lactation and Health Outcomes in Mothers and Their Children: A NESR Systematic Review

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 795-795
Author(s):  
Julie Nevins ◽  
Maureen Spill ◽  
Sharon M Donovan ◽  
Kathryn Dewey ◽  
Rachel Novotny ◽  
...  
Keyword(s):  
Systematic Review ◽  
Folic Acid ◽  
Health Outcomes ◽  
Risk Of Bias ◽  
Dietary Guidelines ◽  
Fortified Foods ◽  
Folate Status ◽  
Moderate Evidence ◽  
Hypertensive Disorders ◽  
Folic Acid Supplements

Abstract Objectives To inform the Dietary Guidelines for Americans, 2020–2025, USDA and HHS identified the following important public health question for the 2020 Dietary Guidelines Advisory Committee to answer with support from USDA's Nutrition Evidence Systematic Review (NESR) team: What is the relationship between folic acid from supplements and/or fortified foods consumed before and during pregnancy and lactation and health outcomes? Methods The Committee developed protocols to describe how they would use NESR's systematic review methodology to examine the evidence. NESR conducted a literature search and dual-screened the results using pre-defined inclusion and exclusion criteria for articles published between 1980 and 2019. NESR extracted data and assessed risk of bias of included studies. The Committee synthesized the evidence, developed conclusion statements, and graded the strength of the evidence underlying the conclusion statements. Results This systematic review included 30 articles, most of which were well-designed RCTs. Observational studies had risk of bias concerns. The study populations did not fully represent the diversity of the U.S. population. Conclusions Strong evidence indicates that folic acid supplements consumed before and/or during pregnancy are positively associated with folate status. Moderate evidence indicates that folic acid supplements consumed during lactation are positively associated with folate status. Limited evidence suggests that folic acid supplements consumed during early pregnancy may have a beneficial effect on reducing the risk of hypertensive disorders during pregnancy among women at high-risk versus no supplementation. Moderate evidence indicates that higher versus lower levels of folic acid supplements consumed during pregnancy does not affect the risk of hypertensive disorders during pregnancy among women at low-risk. Moderate evidence indicates that folic acid supplements consumed during lactation does not influence folate levels in human milk. Insufficient or no evidence was available to examine folic acid and gestational diabetes or child developmental, or folic acid from fortified foods and any outcome. Funding Sources USDA, Food and Nutrition Service, Center for Nutrition Policy and Promotion.

scholarly journals Health behaviours in 131,182 UK women planning pregnancy

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Beth McDougall ◽  
Kimberley Kavanagh ◽  
Judith Stephenson ◽  
Lucilla Poston ◽  
Angela C. Flynn ◽  
...  
Keyword(s):  
Folic Acid ◽  
Health Behaviours ◽  
Folic Acid Supplementation ◽  
Preconception Health ◽  
Younger Women ◽  
Healthy Pregnancy ◽  
Folic Acid Supplements ◽  
Weekly Physical Activity ◽  
The Uk ◽  
Changes Over Time

Abstract Background A woman’s health at the time of conception lays the foundation for a healthy pregnancy and the lifelong health of her child. We investigated the health behaviours of UK women planning pregnancy. Methods We analysed survey data from the ‘Planning for Pregnancy’ online tool (Tommy’s, UK). We described all women planning pregnancy and compared the frequency of non-adherence to preconception recommendations in women who had already stopped contraception (active planners) and those who had not (non-active planners). Results One hundred thirty-one thousand one hundred eighty-two women from across the UK were included, of whom 64.8% were actively planning pregnancy. Of the whole cohort, twenty percent were smokers and less than one third took folic acid supplements (31.5%). Forty two percent engaged in less than the recommended 150 min of weekly physical activity and only 53.3% consumed five portions of fruit or vegetables 4 days a week. Smokers were 1.87 times more likely to be active planners than non-smokers (95% CI 1.79–1.94), and women who took folic acid were 7 times more likely to be active planners (95% CI 6.97–7.59) compared to women who did not. Smoking, drug use and lack of folic acid supplementation were common in younger women and those who were underweight. Conclusions This unique survey of UK women has identified poor adherence to preconception recommendations in those planning pregnancies and supports the need for a greater public health focus on preconception health. This study provides a contemporary basis from which to inform preconception health advice and a benchmark to measure changes over time.

scholarly journals Utilization of preconception care and its impacts on health behavior changes among expectant couples in Shanghai, China

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Li Du ◽  
Xuena La ◽  
Liping Zhu ◽  
Hong Jiang ◽  
Biao Xu ◽  
...  
Keyword(s):  
Folic Acid ◽  
Child Health ◽  
Health Behavior ◽  
Pregnant Women ◽  
Preconception Care ◽  
Behavior Changes ◽  
Care Services ◽  
Folic Acid Supplements ◽  
Health Behavior Changes ◽  
And Child Health

Abstract Background Preconception care is an opportunity for detecting potential health risks in future parents and providing health behavior education to reduce morbidity and mortality for women and their offspring. Preconception care has been established in maternal and child health hospitals in Shanghai, China, which consists of health checkups, health education and counseling. This study investigated factors associated with the utilization of preconception care, and the role of preconception care on health behavior changes before conception among pregnant women and their partners. Methods A cross-sectional study was conducted among pregnant women at three maternal and child health hospitals in Shanghai. The participants were invited to complete a self-administered questionnaire on the utilization of preconception care and health behavioral changes before conception. Results Of the 948 recruited pregnant women, less than half (42.2%) reported that they had utilized preconception care before the current pregnancy. Unplanned pregnancy, unawareness of preconception care and already having a general physical examination were the main reasons for not attending preconception care. The two main sources of information about preconception care were local community workers and health professionals. Younger women and the multipara were less likely to utilize preconception care. Women who utilized preconception care were more likely to take folic acid supplements before conception [Adjusted Odds Ration (aOR) 3.27, 95% Confidence Interval (CI) 2.45–4.36, P < 0.0001]. The partners of pregnant women who had attended preconception care services were more likely to stop smoking [aOR 2.76, 95%CI 1.48–5.17, P = 0.002] and to stop drinking [aOR 2.13, 95%CI 1.03–4.39, P = 0.041] before conception. Conclusions Utilization of preconception care was demonstrated to be positively associated with preconception health behavior changes such as women taking folic acid supplements before pregnancy, their male partner stopping smoking and drinking before conception. Future studies are needed to explore barriers to utilizing preconception care services and understand the quality of the services. Strategies of promoting preconception care to expectant couples, especially to young and multipara women, should be developed to further improve the utilization of the services at the community level.

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