Study of correlation between serum uric acid and fasting blood glucose in type 2 diabetics, their healthy offspring’s matching with healthy controls

2018 ◽  
Vol 8 (2) ◽  
pp. 32-36
Author(s):  
G Manogna ◽  
◽  
Mohammed Jaffer ◽  
Keyword(s):  
Uric Acid ◽  
Blood Glucose ◽  
Serum Uric Acid ◽  
Fasting Blood Glucose ◽  
Healthy Controls ◽  
Type 2 Diabetics

scholarly journals ASSOCIATION OF SERUM SIALIC ACID AND SERUM URIC ACID LEVELS WITH FASTING BLOOD GLUCOSE LEVELS IN TYPE-2 DIABETES MELLITUS PATIENTS

2020 ◽  
pp. 83-86
Author(s):  
YENDREMBAM PASCAL SINGH ◽  
VED PAL SINGH PUNIA ◽  
GLADYS RAI ◽  
MANOJ KUMAR NANDKEOLIAR
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Blood Glucose ◽  
Sialic Acid ◽  
Serum Uric Acid ◽  
Fasting Blood Glucose ◽  
Serum Sialic Acid

Objectives: The objective of the study was to estimate the serum sialic acid and serum uric acid levels in patients with type-2 diabetes mellitus and non-diabetic individuals and determining the association of serum sialic acid and serum uric acid levels with fasting blood glucose levels in patients with type-2 diabetes mellitus and also in non-diabetic individuals. Methods: The study was a cross-sectional analysis where 70 individuals in the age group of 30–70 years participated during 6 months period. This included two groups, one for type-2 diabetes patients as cases and other non-diabetics as controls. In each group, 35 individuals participated. There were 15 males and 20 females in type-2 diabetic group and 16 males and 19 females in non-diabetic group. Fasting blood glucose, serum sialic acid, and serum uric acid were estimated in both the groups. Results: In this study, the serum sialic acid levels of type-2 diabetes mellitus were shown to be increased (76.60 ± 7.89) when compared to non-diabetics (39.66 ± 9.55) with a statistically significant, p < 0.001. The serum uric acid concentrations were also found to be slightly elevated in type-2 diabetes mellitus (4.48 ± 0.79) when compared to non-diabetics (4.28 ± 0.89) with a statistically non-significant, p = 0.323. Conclusion: Based on this study, it is concluded that serum sialic acid and serum uric acid levels have been found to be positively associated with type- 2 diabetes mellitus in both men and women, indicating the risk of developing microvascular complications in those patients. Therefore, estimating the sialic acid and uric acid levels can aid in the early diagnosis and prevention of microvascular complications caused by type-2 diabetes mellitus.

scholarly journals ANGKA BANDING KADAR ASAM URAT AIR KEMIH TERHADAP SERUM DI DIABETES MELITUS TIPE 2 (Ratio of Urinary Uric Acid Levels and Serum Uric Acid in Type 2 Diabetes Mellitus)

2018 ◽  
Vol 21 (1) ◽  
pp. 28
Author(s):  
Amarensi Milka Betaubun ◽  
Fitriani Mangarengi ◽  
Ruland DN Pakasi
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Blood Glucose ◽  
Serum Uric Acid ◽  
Colorimetric Method ◽  
Urinary Levels ◽  
Urine Serum

Diabetes Mellitus (DM) belongs to the group of metabolic diseases. The long-term complications of diabetes such as: diabeticretinopathy, neuropathy, and nephropathy, can be prevented or reduced by controlling the blood glucose levels. Impaired glucose tolerance,hypertension and dyslipidemia can decrease the disappearance from proximal tubules resulting in an increase in serum uric acid. The aimof the study to know the ratio of uric acid urine/serum in DMT2 with controls. This research study used a cross sectional study was andconducted on 35 samples of type 2 diabetes mellitus and 35 control samples of In- and Out-patient Clinics at the Dr. Wahidin SudirohusodoHospital, Makassar. The blood glucose, uric acid levels and urine uric acid were examined by ABX Pentra 400 (colorimetric method). Thenumber of DMT2 male patients was higher than females. Most of their age were between 50−54 years. The ratio of the urinary levels ofurine/serum UA was positively correlated to: age, sex, urine UA in DMT2 and control. Their data were analyzed with unpaired t test (p =0.00). This research showed that the ratio of urine/serum UA in DMT2 was 1.5 times than the controls. The results of this study showedan increase in the ratio of urinary levels of serum uric acid as 1.5 times higher than the controls.

scholarly journals A STUDY OF SERUM URIC ACID LEVELS IN TYPE 2 DIABETES MELLITUS CASES AND ITS COMPARISON WITH THE SERUM CREATININE LEVELS

2021 ◽  
pp. 20-22
Author(s):  
Shajahan Shajahan ◽  
Koneru Sri Lahari ◽  
P. Kiranmai
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Creatinine ◽  
Serum Uric Acid ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
P Value

BACKGROUND:Type 2 Diabetes Mellitus is a major non-communicable disease resulting from insulin resistance and is associated with cardiovascular,neurological and renal complications.Recent studies show association of hyperuricemia and Diabetes Mellitus.Uric acid increases oxidative stress that leads to vascular dysfunction and high intra glomerular pressure leading to renal complications.High serum creatinine is an indicator of renal compromise. OBJECTIVES: To evaluate serum uric acid and serum creatinine levels in type 2 diabetes mellitus patients and to find association between them. METHODOLOGY: The study was conducted in Osmania general hospital. Fifty cases of established Type 2 Diabetes Mellitus formed the study group and 50 normal healthy individuals formed the control group. Serum uric acid, Fasting Blood Glucose (FBS) and serum creatinine were estimated by colorimetric enzymatic methods on Beckman coulter AU5800.Mean values were compared in cases and controls using student t- test.Study group was further studied under 2 subgroups with serum Uric acid < 7 mg/dl and ≥7 mg/dl.In these 2 subgroups the association of Serum uric acid with FBS and creatinine was analysed statistically. RESULTS: Serum uric acid were found high in cases(7.63+/- 3.36)as compared to controls(4.48+/- 1.09) p value < 0.001.Serum creatinine were also high in cases(1.59+/- 1.39 )as compared to controls ( 0.87+/- 0.29) p value <0.005.Study subgroup with serum uric acid ≥7 mg/dl was associated with high creatinine and high fasting blood sugar levels when compared to subgroup with serum uric acid <7 mg/dl. CONCLUSION: Our study showed increased serum uric acid and serum creatinine levels in cases when compared to controls.There was significant association between high serum uric acid and high creatinine levels in cases.Therefore,it is important to measure serum uric acid and serum creatinine levels in diabetics for early detection of renal pathology.

scholarly journals Lack of Associations between Elevated Serum Uric Acid and Components of Metabolic Syndrome Such as Hypertension, Dyslipidemia, and T2DM in Overweight and Obese Chinese Adults

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Li Li ◽  
Qifa Song ◽  
Xi Yang
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Blood Glucose ◽  
Serum Uric Acid ◽  
Muscle Mass ◽  
Alanine Aminotransferase ◽  
Glycosylated Hemoglobin ◽  
Fasting Blood Glucose ◽  
Elevated Serum ◽  
Chinese Adults

The overweight and obese population experiences a higher occurrence of both hyperuricemia and metabolic syndrome. The present study was to explore the relationship between serum uric acid and metabolic syndrome-related risk factors among 409 obese Chinese adults (254 women and 155 men) with >24 kg/m2 BMI. Based on sex-specific reference ranges, 233 (57%) patients showed elevated serum uric acid. A total of 15 attributes were selected to assess the associations between elevated serum uric acid and components of metabolic syndrome, including serum uric acid, total cholesterol, HDL-C, LDL-C, triglyceride, systolic blood pressure, fasting blood glucose, glycosylated hemoglobin, HOMA-IR, alanine aminotransferase, creatinine, urine microalbumin, muscle mass amount, BMI, and age. Among the participants stratified into three groups of grade I, grade II, and grade III obesity, as well as among the participants stratified into male and female groups, univariate correlation analysis identified a negative association (P<0.01) for age, positive associations (P<0.01) for BMI, muscle mass, alanine aminotransferase, and creatinine. The stepwise multivariate logistic regression proved similar associations for age, BMI, creatinine, and alanine aminotransferase. No significant associations were testified between serum uric acid levels and cholesterol, HDL-C, LDL-C, triglyceride, fasting blood glucose, glycosylated hemoglobin, HOMA-IR, and urine microalbumin. Factor analysis illustrated that 15 attributes could be grouped into two common factors and five individual factors. A common underlying factor was identified among uric acid, muscle mass, creatinine, alanine aminotransferase, and BMI. The results indicate that serum uric acid has no apparent association with metabolic syndromes that are commonly characterized by hypertension, dyslipidemia, and T2DM.

scholarly journals Status of serum uric acid in diabetic and non-diabetic subjects.

2020 ◽  
Vol 27 (11) ◽  
pp. 2458-2462
Author(s):  
Naveed Ahsan ◽  
Fasiha Fatima ◽  
Sarwat Jahan ◽  
Shahid Zafar ◽  
Jai Kershan
Keyword(s):  
Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Medical Center ◽  
Fasting Blood Glucose ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Glucose Levels ◽  
Relative Deficiency

Diabetes Mellitus is a chronic metabolic disorder which occurs due to absolute or relative deficiency of insulin hormone and the diabetic patients are more prone to develop stroke, heart attack, kidney failure, blindness, coronary artery disease, neuropathy and gangrene. Increased uric acid levels in serum are one of the metabolic abnormalities associated with diabetes mellitus type 2. Objectives: The purpose of the research is to assess the status of serum uric acid in non-diabetic and diabetic subjects. Study Design: Cross Sectional Comparative study. Setting: Department of Medicine Jinnah Postgraduate Medical Center, Karachi. Period: Feb 2018 till September 2018. Material & Methods: A total of 80 subjects of both sexes were taken and divided into two groups. Fasting glucose levels, serum uric acid were performed by enzymatic method. Results: This study showed significantly raised levels of serum uric acid and Fasting blood glucose (FBS) in diabetic type 2 subjects when compared to non-diabetic subjects(p<0.01). Conclusion: The results of the present study suggests that compared to non‐diabetic subject’s diabetic subjects have significantly higher level of uric acid.

scholarly journals THE STUDY ON ASSOCIATION BETWEEN URIC ACID AND ALBUMINURIA IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

2021 ◽  
pp. 1-3
Author(s):  
Sk. Adnan Yusuf ◽  
Debarshi Jana
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Fasting Blood Glucose ◽  
General Medicine ◽  
Urinary Albumin ◽  
Chronic Hyperglycemia

Introduction: Diabetes Mellitus (DM) is a metabolic disorder characterized by the presence of chronic hyperglycemia accompanied by greater or lesser impairment in the metabolism of carbohydrates, lipids and proteins resulting from defects in insulin secretion, action or both. Aims & objectives: The aim of this study is to evaluate the association between serum uric acid & urinary Albumin to Creatinine Ratio (ACR) among patients with type 2 diabetes mellitus. Material and Methods: 83 patients aged between 40 to 80 years was selected from Medicine OPD and indoor wards, Department of General Medicine, KPC Medical College & Hospital, West Bengal from 1august 2019 to 1august 2020. Type 2 Diabetics Melitus (T2DM) patients, Age: between 40 to 80 years. Age, Body weight, Height, BMI, serum uric acid, urinary albumin to creatine ratio (ACR), Fasting Blood Glucose (FBG), HbA1C, lipid profile, serum creatinine. Conclusion: Present study found that positive correlation between serum uric acid with DBP, FBS, HB1AC, Serum Createnine, TG and LDL. There was negative correlation between serum uric acid with GFR and HDL, which were statistically significant.

scholarly journals IMPACT OF NUTRITION EDUCATION AND DIET THERAPY ON GLYCEMIC CONTROL IN PATIENTS WITH TYPE 2 DIABETES

2020 ◽  
pp. 1-2
Author(s):  
B. Premagowri
Keyword(s):  
Blood Glucose ◽  
Glycemic Control ◽  
Nutrition Education ◽  
Diabetes Management ◽  
Fasting Blood Glucose ◽  
Diet Therapy ◽  
Information Communication ◽  
Type 2 Diabetics ◽  
Post Test

Lifestyle modications including alteration of diet and physical activity are the rst lines of management during diabetes. The objective of the study was to evaluate the effects of nutrition education on glycemic control in type 2 diabetics. Around 410 newly detected type 2 diabetics were selected and socio-economic, anthropometric, dietary survey and biochemical data were collected by using the standard interview schedule. Programmed nutrition education using Information Communication Technology (ICT) were conducted to all the selected subjects. Using questionnaire, pre and post test was conducted to nd the knowledge improvement on diabetes management. The mean scores 9.90±1.60 obtained in pre-test were increased to 17.85 ±1.15 after nutrition education. For the selected subjects without hypoglycemic drugs, fasting blood glucose reduced by 27.92mg/dl (t= 8.612), post prandial blood glucose reduced by 53.94mg/dl (t= 14.442) and HbA1c reduced by 0.55% (t= 13.987). Thus, imparting nutrition education through ICT tools was found to be effective in improving the level of nutrition knowledge.

scholarly journals Glycosuria Lowers Serum Uric Acid in Type 2 Diabetics

2018 ◽  
Vol 42 (2) ◽  
pp. 173-181
Author(s):  
Satoru Kuriyama ◽  
Tomoko Nakano ◽  
Kosuke Honda ◽  
Naoki Sugano ◽  
Yukio Maruyama ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Type 2 Diabetics

CORRELATION OF SERUM URIC ACID LEVEL WITH GLYCAEMIC STATUS IN TYPE 2 DIABETES MELLITUS PATIENTS IN DARBHANGA

2021 ◽  
pp. 68-70
Author(s):  
Mritunjay Kumar ◽  
Sheela Kumari ◽  
Debarshi Jana
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Blood Glucose ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level

Objectives : Our study was to detect the correlation of serum uric acid level with glycaemic status and with lipid prole. And also evaluate the various biochemical parameters, anthropometric measurements, blood pressure, serum uric acid level and associated factors. Methods: A 100 subjects with type 2 diabetes mellitus as a case and 100 subjects with non diabetics as control with age group greater than 40 years were enrolled in this study. A detail history, dietary pattern, clinical examination and relevant investigation were performed. Anthropometric examination like as measurement of BMI, measurement of waist-hip ratio and biochemical investigations like as blood glucose, serum HbA1c estimation, serum uric acid and serum lipid prole were performed to all subjects. Results : Data was analyzed by using SPSS software. Mean±SD was observed. P value was taken ≤0.05 for signicant differences. Conclusion : Type 2 diabetes mellitus patients is a strong negative correlation between blood glucose level and serum uric acid level. So that serum uric acid can be used as an important parameter to assess future cardiovascular risk in a type 2 diabetes mellitus patient.

scholarly journals Serum uric acid in type 2 diabetics

2008 ◽  
Vol 34 (1) ◽  
pp. 69-75
Author(s):  
Jamal M. Hammed ◽  
Bassam E . Hanna
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Type 2 Diabetics
Sign in / Sign up

Export Citation Format

Share Document