scholarly journals Increased Copper in Individuals with Autism Normalizes Post Zinc Therapy More Efficiently in Individuals with Concurrent GI Disease

2011 ◽  
Vol 4 ◽  
pp. NMI.S6827 ◽  
Author(s):  
Anthony J. Russo
Keyword(s):  
Plasma Levels ◽  
Inductively Coupled Plasma ◽  
Plasma Zinc ◽  
Autistic Children ◽  
Disease Group ◽  
Lower Plasma ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry ◽  
And Gender ◽  
Copper Plasma

Aim To assess plasma zinc and copper concentration in individuals with autism. Subjects and Methods Plasma from 79 autistic individuals, and 18 age and gender similar neurotypical controls, were tested for plasma zinc and copper using inductively-coupled plasma-mass spectrometry. Results Autistic individuals had significantly elevated plasma levels of copper and Cu/Zn and lower, but not significantly lower, plasma Zn compared to neurotypical controls. Zn levels increased significantly in autistic individuals with and without GI disease after zinc therapy. Cu decreased significantly after zinc therapy in the GI disease group but not in the autistic group without GI disease. Autistic children significantly improved with respect to hyperactivity and stimming after zinc therapy in autistic children with GI disease. Autistic children without GI disease did not improve in these symptoms after the same therapy. Discussion These results suggest an association between zinc and copper plasma levels and autism, and they suggest that zinc therapy may be most effective at lowering copper levels in autistic children with GI disease.

scholarly journals Decreased Zinc and Increased Copper in Individuals with Anxiety

2011 ◽  
Vol 4 ◽  
pp. NMI.S6349 ◽  
Author(s):  
A.J. Russo
Keyword(s):  
Plasma Levels ◽  
Inductively Coupled Plasma ◽  
Zinc Concentration ◽  
Plasma Zinc ◽  
Normal Range ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry ◽  
Anti Oxidant ◽  
Preliminary Study ◽  
Post Therapy

Aim To assess plasma zinc and copper levels in individuals with anxiety and to test the hypothesis that there is a relationship between copper and zinc concentration and improved symptoms. Subjects and Methods Serum from 38 individuals with anxiety and 16 neurotypical age, gender and size similar controls were tested for plasma zinc and copper concentration using inductively-coupled plasma-mass spectrometry. Zinc and copper levels, pre and post therapy, were compared and assessed for perceived anxiety symptoms. Results In this preliminary study, individuals with anxiety had significantly higher plasma levels of Cu ( P = 0.0348), Cu/Zn ( P = 0.0493) and lower Zn ( P = 0.0294) compared to controls. Zn levels normalized (increased to the normal range) and Cu/Zn significantly decreased after zinc therapy ( P = 0.0004, P = 0.0033, respectively), but Cu did not significantly decrease (0.3577). These same patients improved significantly with respect to perceived overall symptoms after zinc and anti-oxidant therapy ( P = 0.013). Discussion These results suggest an association between Zn plasma levels and individuals with anxiety, demonstrate that zinc therapy is effective in increasing zinc plasma levels, and show that zinc supplementation may play a role in improved symptoms.

scholarly journals Analysis of Plasma Zinc and Copper Concentration, and Perceived Symptoms, in Individuals with Depression, Post Zinc and Anti-Oxidant Therapy

2011 ◽  
Vol 4 ◽  
pp. NMI.S6760 ◽  
Author(s):  
A.J. Russo
Keyword(s):  
Symptom Severity ◽  
Inductively Coupled Plasma ◽  
Copper Concentration ◽  
Plasma Zinc ◽  
Elevated Plasma ◽  
Inductively Coupled ◽  
Clinically Depressed ◽  
Plasma Mass Spectrometry ◽  
Anti Oxidant ◽  
Normal Controls

Aim To assess plasma Zn and Cu levels in individuals with depression. Subjects and Methods Plasma from 73 clinically depressed individuals, 38 individuals with anxiety and 16 controls were tested for plasma Zn and Cu concentration using inductively-coupled plasma-mass spectrometry. Results Depressed individuals, with and without secondary anxiety, had decreased plasma Zn and elevated plasma Cu compared to controls. Zn normalized (increased to the level of normal controls) but Cu increased in individuals with depression (with and without secondary anxiety), after Zn therapy, whereas both plasma Zn increased and Cu levels decreased in anxiety, with and without secondary depression, after Zn therapy. Individuals with depression, with and without secondary anxiety, had significantly higher symptom severity when compared to neurotypical controls. Symptom severity in individuals with anxiety (both with and without secondary depression) significantly decreased after Zn therapy, whereas symptoms remained the same in individuals with primary depression. Discussion These data show an association between Zn and Cu plasma levels and clinically depressed individuals, and suggest that high Cu levels are associated with high symptom severity.

scholarly journals Alterations of Hair and Nail Content of Selected Trace Elements in Nonoccupationally Exposed Patients with Chronic Depression from Different Geographical Regions

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Anna Błażewicz ◽  
Kuan-Yung Liao ◽  
Heng-Hsin Liao ◽  
Przemysław Niziński ◽  
Łukasz Komsta ◽  
...  
Keyword(s):  
Trace Elements ◽  
Inductively Coupled Plasma ◽  
Healthy Subjects ◽  
Principal Component ◽  
Chronic Depression ◽  
Logistic Regression Models ◽  
Inductively Coupled ◽  
Geographical Regions ◽  
Plasma Mass Spectrometry ◽  
And Gender

The aim of this study was to determine if altered levels of selected trace elements manifest themselves during chronic depression. To identify elements strongly associated with chronic depression, relationships between the elemental contents of hair and nails and the interelement correlations were checked. Inductively coupled plasma mass spectrometry and ion chromatography were used to evaluate the contents of Zn, Cu, Co, Pb, Mn, and Fe in hair and nail samples from a total of 415 subjects (295 patients and 120 healthy volunteers). The study included logistic regression models to predict the probability of chronic depression. To investigate possible intercorrelations among the studied elements, the scaled principal component analysis was used. The research has revealed differences in TE levels in the group of depressed men and women in comparison to the healthy subjects. Statistically significant differences in both hair and nails contents of several elements were observed. Our study also provides strong evidence that the intermediary metabolism of certain elements is age- and gender-dependent. Zn, Mn, Pb, and Fe contents in hair/nails seem to be strongly associated with chronic depression. We found no statistically significant residence-related differences in the contents of studied elements in nonoccupationally exposed patients and healthy subjects.

Decreased Serum Hepatocyte Growth Factor (HGF) in Individuals with Schizophrenia Normalizes after Zinc and B-6 Therapy

2010 ◽  
Vol 3 ◽  
pp. PRI.S6145
Author(s):  
A.J. Russo ◽  
Robert deVito
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Serum Levels ◽  
Age And Gender ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry ◽  
And Gender ◽  
Zinc Levels ◽  
Hepatocyte Growth ◽  
Post Therapy

Aim To assess serum HGF concentration in individuals with schizophrenia and investigate the efficacy of zinc and B-6 therapy on these levels. Subjects and methods Serum from 18 individuals diagnosed with schizophrenia and 19 age and gender similar controls ( P = 0.18) were tested for HGF concentration using ELISAs, and tested for copper and zinc plasma levels using inductively-coupled plasma-mass spectrometry. Results HGF serum levels of individuals with schizophrenia, before zinc and B-6 therapy, were significantly lower than age and gender similar controls ( P = 0.016), and significantly lower in schizophrenia patients pre-therapy compared to post therapy ( P = 0.028). HGF levels normalized (reached levels similar to controls) post-therapy. Zinc levels in these same individuals also normalized, and perceived symptoms, particularly anxiety ( P = 0.03), improved significantly after therapy. Discussion These results suggest an association between low HGF levels and schizophrenia and demonstrate that zinc and B-6 therapy may be associated with the normalization of HGF levels and perceived improvement in symptoms.

scholarly journals Increased lead concentrations in the hairs of radiographers in general hospitals

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mao-Chin Hung ◽  
Peter Chang
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Scalp Hair ◽  
General Hospitals ◽  
Inductively Coupled ◽  
Environmental Lead ◽  
Hair Samples ◽  
Plasma Mass Spectrometry ◽  
Lead Shielding ◽  
And Gender

AbstractThis study investigated lead concentrations in the hairs of radiographers working in the radiological departments of general hospitals that used lead shielding for radiation protection. We collected scalp hair samples from 32 radiographers working in four radiology departments with lead shielding and 18 administration personnel in the same hospitals without lead shielding. Samples were analyzed for lead concentrations by inductively coupled plasma mass spectrometry. As a result, lead concentrations in the hairs of the radiological technologists were significantly higher than those in the administration staffs (0.72 ± 0.51 vs. 0.19 ± 0.27 μg/g, P < 0.001). The hair lead concentrations were positively and significantly associated with environmental lead concentrations (r = 0.6, P = 0.001), but not associated with age, working duration, and gender distribution.

scholarly journals Decreased Serum Hepatocyte Growth Factor (HGF) in Individuals with Bipolar Disorder Normalizes after Zinc and Anti-oxidant Therapy

2010 ◽  
Vol 3 ◽  
pp. NMI.S5528 ◽  
Author(s):  
A.J. Russo
Keyword(s):  
Bipolar Disorder ◽  
Serum Concentration ◽  
Inductively Coupled Plasma ◽  
Serum Levels ◽  
Age And Gender ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry ◽  
And Gender ◽  
Zinc Levels ◽  
Bipolar Patients

Aim To assess serum HGF concentration in individuals with bipolar disorder and investigate the efficacy of zinc therapy on these levels. Subjects and Methods Serum from 35 individuals diagnosed with bipolar disorder and 19 age and gender similar controls were tested for HGF concentration using ELISAs, and copper and zinc plasma levels using inductively-coupled plasma-mass spectrometry. Results HGF serum levels of individuals with bipolar disorder were significantly lower than age and gender similar controls ( P = 0.0021). HGF serum concentration was significantly lower in Bipolar patients pre-therapy ( P = 0.0009) and HGF levels normalized post-therapy. Zinc levels in these same individuals also normalized ( P = 0.0046) and patient's perceived severity of Bipolar symptoms significantly decreased after therapy ( P = 0.0003). We also found a significant direct correlation between Zinc and HGF serum concentration in the bipolar patients ( P = 0.04). Discussion These results suggest an association between low HGF levels and bipolar disorder and also demonstrate that zinc therapy may be associated with the normalization of HGF levels and decrease in severity of disease.

scholarly journals Analysis of eight nutrient elements in peripheral blood of children and adolescents using inductively coupled plasma‐mass spectrometry

2021 ◽  
Author(s):  
Fang Luan ◽  
Bin Liu ◽  
Shuzhen Sun ◽  
Yuan Chen ◽  
Yanqiu Xu ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Whole Blood ◽  
Inductively Coupled Plasma ◽  
Age Groups ◽  
Reference Intervals ◽  
Age And Gender ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
And Gender

Abstract Background Several researches have been conducted on the associations between elements and diseases. Few studies have examined trace elements in young people’s hair. The objective of this study is to investigate the influence of age, gender and season on the contents of magnesium (Mg), calcium (Ca), Iron (Fe), copper (Cu), zinc (Zn), manganese (Mn), selenium (Se) and strontium (Sr) as well as to establish the reference intervals (RIs). Methods We conducted a retrospective study of 589 apparently healthy children and adolescents under 19 years old. Quantitative analysis has been carried out using inductively coupled plasma-mass spectrometry (ICP-MS). Eight nutrient elements in peripheral blood of children and adolescents in eastern China were grouped according to age, sex or season, and analyzed using and Mann-Whitney U test and spearman statistical analyses. RIs were defined by using 95% confidence interval. Results Precisions of ICP-MS detecting for Mg, Ca, Fe, Cu, Zn, Mn, Se and Sr are 2.8%~12.2%. The linearity were all > 0.999 and the bias were all within 10%. Differences between contents of particularly Mg, Fe, Cu and Zn in girls’ and boys’ whole blood were found, and higher contents of Mg, Cu for boys were measured in some age groups. Positive correlations for Fe, Zn, Se and Sr, while negative for Ca and Cu were found with age. And substantial differences between age groups were stated. In general, an increasing trend was found for bioelements (Fe, Zn,Se) both for girls and boys in all age groups, while for Ca and Cu changes were even decreasing for children and teenagers. The most frequently correlating element pairs were Fe-Zn, Mg-Se, and Fe-Se in five successive age groups. Lower contents of essential elements (Mg, Ca, Fe, Zn, Se) were found in summer comparing with other seasons. Finally, the reference interval of each element was initially established according to age and gender grouping. Conclusions The contents of elements in whole blood varies depending mainly on the gender and age of children and adolescents. Besides, season is also a factor that affects the contents of elements in the body. The reference intervals of elements in whole blood grouped by age and gender provide a reference basis for clinical diagnosis and treatment of element-related diseases.

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