scholarly journals Analysis of Plasma Zinc and Copper Concentration, and Perceived Symptoms, in Individuals with Depression, Post Zinc and Anti-Oxidant Therapy

2011 ◽  
Vol 4 ◽  
pp. NMI.S6760 ◽  
Author(s):  
A.J. Russo
Keyword(s):  
Symptom Severity ◽  
Inductively Coupled Plasma ◽  
Copper Concentration ◽  
Plasma Zinc ◽  
Elevated Plasma ◽  
Inductively Coupled ◽  
Clinically Depressed ◽  
Plasma Mass Spectrometry ◽  
Anti Oxidant ◽  
Normal Controls

Aim To assess plasma Zn and Cu levels in individuals with depression. Subjects and Methods Plasma from 73 clinically depressed individuals, 38 individuals with anxiety and 16 controls were tested for plasma Zn and Cu concentration using inductively-coupled plasma-mass spectrometry. Results Depressed individuals, with and without secondary anxiety, had decreased plasma Zn and elevated plasma Cu compared to controls. Zn normalized (increased to the level of normal controls) but Cu increased in individuals with depression (with and without secondary anxiety), after Zn therapy, whereas both plasma Zn increased and Cu levels decreased in anxiety, with and without secondary depression, after Zn therapy. Individuals with depression, with and without secondary anxiety, had significantly higher symptom severity when compared to neurotypical controls. Symptom severity in individuals with anxiety (both with and without secondary depression) significantly decreased after Zn therapy, whereas symptoms remained the same in individuals with primary depression. Discussion These data show an association between Zn and Cu plasma levels and clinically depressed individuals, and suggest that high Cu levels are associated with high symptom severity.

scholarly journals Decreased Zinc and Increased Copper in Individuals with Anxiety

2011 ◽  
Vol 4 ◽  
pp. NMI.S6349 ◽  
Author(s):  
A.J. Russo
Keyword(s):  
Plasma Levels ◽  
Inductively Coupled Plasma ◽  
Zinc Concentration ◽  
Plasma Zinc ◽  
Normal Range ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry ◽  
Anti Oxidant ◽  
Preliminary Study ◽  
Post Therapy

Aim To assess plasma zinc and copper levels in individuals with anxiety and to test the hypothesis that there is a relationship between copper and zinc concentration and improved symptoms. Subjects and Methods Serum from 38 individuals with anxiety and 16 neurotypical age, gender and size similar controls were tested for plasma zinc and copper concentration using inductively-coupled plasma-mass spectrometry. Zinc and copper levels, pre and post therapy, were compared and assessed for perceived anxiety symptoms. Results In this preliminary study, individuals with anxiety had significantly higher plasma levels of Cu ( P = 0.0348), Cu/Zn ( P = 0.0493) and lower Zn ( P = 0.0294) compared to controls. Zn levels normalized (increased to the normal range) and Cu/Zn significantly decreased after zinc therapy ( P = 0.0004, P = 0.0033, respectively), but Cu did not significantly decrease (0.3577). These same patients improved significantly with respect to perceived overall symptoms after zinc and anti-oxidant therapy ( P = 0.013). Discussion These results suggest an association between Zn plasma levels and individuals with anxiety, demonstrate that zinc therapy is effective in increasing zinc plasma levels, and show that zinc supplementation may play a role in improved symptoms.

scholarly journals Increased Copper in Individuals with Autism Normalizes Post Zinc Therapy More Efficiently in Individuals with Concurrent GI Disease

2011 ◽  
Vol 4 ◽  
pp. NMI.S6827 ◽  
Author(s):  
Anthony J. Russo
Keyword(s):  
Plasma Levels ◽  
Inductively Coupled Plasma ◽  
Plasma Zinc ◽  
Autistic Children ◽  
Disease Group ◽  
Lower Plasma ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry ◽  
And Gender ◽  
Copper Plasma

Aim To assess plasma zinc and copper concentration in individuals with autism. Subjects and Methods Plasma from 79 autistic individuals, and 18 age and gender similar neurotypical controls, were tested for plasma zinc and copper using inductively-coupled plasma-mass spectrometry. Results Autistic individuals had significantly elevated plasma levels of copper and Cu/Zn and lower, but not significantly lower, plasma Zn compared to neurotypical controls. Zn levels increased significantly in autistic individuals with and without GI disease after zinc therapy. Cu decreased significantly after zinc therapy in the GI disease group but not in the autistic group without GI disease. Autistic children significantly improved with respect to hyperactivity and stimming after zinc therapy in autistic children with GI disease. Autistic children without GI disease did not improve in these symptoms after the same therapy. Discussion These results suggest an association between zinc and copper plasma levels and autism, and they suggest that zinc therapy may be most effective at lowering copper levels in autistic children with GI disease.

scholarly journals Plasma Copper and Zinc Concentration in Individuals with Autism Correlate with Selected Symptom Severity

2012 ◽  
Vol 5 ◽  
pp. NMI.S8761 ◽  
Author(s):  
Anthony J. Russo ◽  
Andrea P. Bazin ◽  
Richard Bigega ◽  
Robert S. Carlson ◽  
Martin G. Cole ◽  
...  
Keyword(s):  
Motor Skills ◽  
Symptom Severity ◽  
Inductively Coupled Plasma ◽  
Zinc Concentration ◽  
Receptive Language ◽  
Fine Motor ◽  
Fine Motor Skills ◽  
Plasma Zinc ◽  
Inductively Coupled ◽  
Copper And Zinc

Aim To assess plasma zinc and copper concentration in individuals with autism and correlate these levels with symptom severity. Subjects and Methods Plasma from 102 autistic individuals, and 18 neurotypical controls, were tested for plasma zinc and copper using inductively-coupled plasma-mass spectrometry. Copper and zinc levels and Cu/Zn were analyzed for possible correlation with severity of 19 symptoms. Results Autistic individuals had elevated plasma levels of copper and Cu/Zn and lower, but not significantly lower, plasma Zn compared to neurotypical controls. There was a correlation between Cu/Zn and expressive language, receptive language, focus attention, hyperactivity, fine motor skills, gross motor skills and Tip Toeing. There was a negative correlation between plasma zinc concentration and hyperactivity, and fine motor skills severity. Discussion These results suggest an association between plasma Cu/Zn and severity of symptoms associated with autism.

Metal-Organic Frameworks vs. Buffers: Case Study of UiO-66 Stability

2020 ◽  
Author(s):  
Daniel Bůžek ◽  
Slavomír Adamec ◽  
Kamil Lang ◽  
Jan Demel
Keyword(s):  
Inductively Coupled Plasma ◽  
Buffer Capacity ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Analytical Techniques ◽  
Aqueous Dispersions ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry ◽  
Metal Organic

<div><p>UiO-66 is a zirconium-based metal-organic framework (MOF) that has numerous applications. Our group recently determined that UiO-66 is not as inert in aqueous dispersions as previously reported in the literature. The present work therefore assessed the behaviour of UiO-66 in buffers: 2-amino-2-(hydroxymethyl)-1,3-propanediol (TRIS), 4-(2-hydroxyethyl)piperazine-1-ethane sulfonic acid (HEPES), N-ethylmorpholine (NEM) and phosphate buffer (PB), all of which are commonly used in many UiO-66 applications. High pressure liquid chromatography and inductively coupled plasma mass spectrometry were used to monitor degradation of the MOF. In each buffer, the terephthalate linker was released to some extent, with a more pronounced leaching effect in the saline forms of these buffers. The HEPES buffer was found to be the most benign, whereas NEM and PB should be avoided at any concentration as they were shown to rapidly degrade the UiO-66 framework. Low concentration TRIS buffers are also recommended, although these offer minimal buffer capacity to adjust pH. Regardless of the buffer used, rapid terephthalate release was observed, indicating that the UiO-66 was attacked immediately after mixing with the buffer. In addition, the dissolution of zirconium, observed in some cases, intensified the UiO-66 decomposition process. These results demonstrate that sensitive analytical techniques have to be used to monitor the release of MOF components so as to quantify the stabilities of these materials in liquid environments.</p></div>

Single Particle Inductively Coupled Plasma Mass Spectrometry: Investigating Nonlinear Response Observed in Pulse Counting Mode and Extending the Linear Dynamic Range by Compensating for Dead Time Related Count Losses on a Microsecond Timescale

2019 ◽  
Author(s):  
Ingo Strenge ◽  
Carsten Engelhard
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Nonlinear Response ◽  
Dynamic Range ◽  
Dead Time ◽  
Inorganic Nanoparticles ◽  
Linear Dynamic Range ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

<p>The article demonstrates the importance of using a suitable approach to compensate for dead time relate count losses (a certain measurement artefact) whenever short, but potentially strong transient signals are to be analysed using inductively coupled plasma mass spectrometry (ICP-MS). Findings strongly support the theory that inadequate time resolution, and therefore insufficient compensation for these count losses, is one of the main reasons for size underestimation observed when analysing inorganic nanoparticles using ICP-MS, a topic still controversially discussed.</p>

Sign in / Sign up

Export Citation Format

Share Document