HLA-A, -B, -C, -DRB1, and -DQB1 Allele Lineages and Haplotype Frequencies among Saudis

2014 ◽  
pp. 1 ◽  
Author(s):  
Osman ◽  
F Gonzalez-Galarza ◽  
M Mubasher ◽  
H Al-Harthi ◽  
N El Sheikh ◽  
...  
Keyword(s):  
Haplotype Frequencies ◽  
Dqb1 Allele

HLA-A, -B, -C, -DRB1 and -DQB1 allele and haplotype frequencies in the Serbian population

2014 ◽  
Vol 75 (3) ◽  
pp. 218-226 ◽  
Author(s):  
Zorana Andric ◽  
Dusan Popadic ◽  
Barbara Jovanovic ◽  
Ivana Jaglicic ◽  
Svetlana Bojic ◽  
...  
Keyword(s):  
Haplotype Frequencies ◽  
Dqb1 Allele

HLA-A, -B, -C, -DRB1 and -DQB1 allele and haplotype frequencies and phylogenetic analysis of Bahraini population

Gene ◽  
2020 ◽  
Vol 735 ◽  
pp. 144399
Author(s):  
Abdelhafidh Hajjej ◽  
F. Lisa Saldhana ◽  
Rana Dajani ◽  
Wassim Y. Almawi
Keyword(s):  
Phylogenetic Analysis ◽  
Haplotype Frequencies ◽  
Dqb1 Allele ◽  
Bahraini Population

HLA-DRB1,-DQA1 and -DQB1 Allele and Haplotype Frequencies in Female Patients with Early Onset Breast Cancer

2011 ◽  
Vol 18 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Majid Mahmoodi ◽  
Hedayat Nahvi ◽  
Mahdi Mahmoudi ◽  
Amir Kasaian ◽  
Mohammad-Ali Mohagheghi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Onset ◽  
Early Onset Breast Cancer ◽  
Female Patients ◽  
Haplotype Frequencies ◽  
Dqb1 Allele

HLA-A, -B, -C, -DRB1 and -DQB1 allele and haplotype frequencies of 1463 umbilical cord blood units typed in high resolution from Bogotá, Colombia

2019 ◽  
Vol 80 (7) ◽  
pp. 425-426 ◽  
Author(s):  
Iván Aurelio Páez-Gutiérrez ◽  
David Guillermo Hernández-Mejía ◽  
Diana Vanegas ◽  
Bernardo Camacho-Rodríguez ◽  
Ana María Perdomo-Arciniegas
Keyword(s):  
High Resolution ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Haplotype Frequencies ◽  
Dqb1 Allele

scholarly journals HLA-A, -B, -C, -DRB1, and -DQB1 Allele Lineages and Haplotype Frequencies among Saudis

2014 ◽  
Vol 6 ◽  
pp. III.S16769
Author(s):  
Awad E. Osman ◽  
Faviel F. Gonzalez-Galarza ◽  
Mohamed Mubasher ◽  
Hanan Al-Harthi ◽  
Nezar Eltayeb Elsheikh ◽  
...  
Keyword(s):  
Principal Component ◽  
Human Leukocyte ◽  
Marrow Transplant ◽  
Genetic Distances ◽  
Specific Oligonucleotide Probe ◽  
Haplotype Frequencies ◽  
Medical City ◽  
Reported Data ◽  
Sequence Specific Oligonucleotide Probe ◽  
Dqb1 Allele

There are few reported studies on Saudi population for human leukocyte antigens (HLA) genes. We investigated allele lineages (two-digit) and haplotype frequencies of HLA-A, -B, -C, -DRB1, and -DQB1 loci in 499 healthy unrelated individuals, selected from potential bone marrow transplant (BMT) families’ donors at King Fahad Medical City (KFMC), Saudi Arabia (SA). Genotyping was performed by Sequence Specific Oligonucleotide Probe (SSOP) utilizing a Luminex-based method. Allele lineages and haplotype frequencies were evaluated along with principal component analysis (PCA) to compare findings with previously reported data on Arab related populations. A total of 18 allele lineages for HLA-A, 28 for -B, 14 for -C, 13 for -DRB1, and 5 for -DQB1 were detected. High values for linkage disequilibrium indicators were found for B:C ( D’ = 0.86599) and DRB1:DQB1 ( D’ = 0.89468) loci. Additionally, PCA results confirmed previous findings on this population, but also indicated some genetic distances from other Arab related populations. The present study helps in further investigations of this population in anthropological analysis and HLA-associated disease studies.

HLA-A, -B, -C, -DRB1 and -DQB1 allele and haplotype frequencies in Saudis using next generation sequencing technique

2013 ◽  
Vol 82 (4) ◽  
pp. 252-258 ◽  
Author(s):  
A. H. Hajeer ◽  
M. A. Al Balwi ◽  
F. Aytül Uyar ◽  
Y. AlHaidan ◽  
A. AlAbdulrahman ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Next Generation ◽  
Haplotype Frequencies ◽  
Sequencing Technique ◽  
Dqb1 Allele ◽  
Generation Sequencing

scholarly journals Human Leukocyte Antigen-A, B, C, DRB1, and DQB1 Allele and Haplotype Frequencies in a Subset of 237 Donors in the South African Bone Marrow Registry

2018 ◽  
Vol 2018 ◽  
pp. 1-8
Author(s):  
Mqondisi Tshabalala ◽  
Charlotte Ingram ◽  
Terry Schlaphoff ◽  
Veronica Borrill ◽  
Alan Christoffels ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Human Leukocyte Antigen ◽  
South African ◽  
Association Studies ◽  
Human Leukocyte ◽  
The South ◽  
Multiple Allele ◽  
Leukocyte Antigen ◽  
Haplotype Frequencies ◽  
Dqb1 Allele

Human leukocyte antigen- (HLA-) A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 allele and haplotype frequencies were studied in a subset of 237 volunteer bone marrow donors registered at the South African Bone Marrow Registry (SABMR). Hapl-o-Mat software was used to compute allele and haplotype frequencies from individuals typed at various resolutions, with some alleles in multiple allele code (MAC) format. Four hundred and thirty-eight HLA-A, 235 HLA-B, 234 HLA-DRB1, 41 HLA-DQB1, and 29 HLA-C alleles are reported. The most frequent alleles were A∗02:02g (0.096), B∗07:02g (0.082), C∗07:02g (0.180), DQB1∗06:02 (0.157), and DRB1∗15:01 (0.072). The most common haplotype was A∗03:01g~B∗07:02g~C∗07:02g~DQB1∗06:02~DRB1∗15:01 (0.067), which has also been reported in other populations. Deviations from Hardy-Weinberg equilibrium were observed in A, B, and DRB1 loci, with C~DQB1 being the only locus pair in linkage disequilibrium. This study describes allele and haplotype frequencies from a subset of donors registered at SABMR, the only active bone marrow donor registry in Africa. Although the sample size was small, our results form a key resource for future population studies, disease association studies, and donor recruitment strategies.

HLA‐A, B, C, DRB1 and DQB1 allele and haplotype frequencies in volunteer bone marrow donors from Eastern Region of Saudi Arabia

HLA ◽  
2019 ◽  
Author(s):  
Dunia Jawdat ◽  
Mohsen Al‐Zahrani ◽  
Ahmed Al‐Askar ◽  
Hana Fakhoury ◽  
Fatma Aytül Uyar ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Saudi Arabia ◽  
Eastern Region ◽  
Haplotype Frequencies ◽  
Dqb1 Allele
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