scholarly journals Effects of High Fat Feeding on Liver Gene Expression in Diabetic Goto-Kakizaki Rats

2012 ◽  
Vol 6 ◽  
pp. GRSB.S10371 ◽  
Author(s):  
Richard R. Almon ◽  
Debra C. DuBois ◽  
Siddharth Sukumaran ◽  
Xi Wang ◽  
Bai Xue ◽  
...  
Keyword(s):  
Gene Expression ◽  
High Fat ◽  
Liver Gene ◽  
Fat Feeding

Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression

Hepatology ◽  
2009 ◽  
Vol 50 (6) ◽  
pp. 1796-1808 ◽  
Author(s):  
Kimberley D. Bruce ◽  
Felino R. Cagampang ◽  
Marco Argenton ◽  
Junlong Zhang ◽  
Priya L. Ethirajan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mitochondrial Dysfunction ◽  
High Fat ◽  
Adult Mice ◽  
Fat Feeding

scholarly journals Aging and chronic high-fat feeding negatively affect kidney size, function, and gene expression in CTRP1-deficient mice

2021 ◽  
Vol 320 (1) ◽  
pp. R19-R35
Author(s):  
Susana Rodriguez ◽  
Hannah C. Little ◽  
Parnaz Daneshpajouhnejad ◽  
Paride Fenaroli ◽  
Stefanie Y. Tan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heart Function ◽  
Total Protein Content ◽  
High Fat ◽  
Low Fat ◽  
Salt Loading ◽  
Low Fat Diet ◽  
Age Related ◽  
Organ Systems ◽  
Fat Feeding

C1q/TNF-related protein 1 (CTRP1) is an endocrine factor with metabolic, cardiovascular, and renal functions. We previously showed that aged Ctrp1-knockout (KO) mice fed a control low-fat diet develop renal hypertrophy and dysfunction. Since aging and obesity adversely affect various organ systems, we hypothesized that aging, in combination with obesity induced by chronic high-fat feeding, would further exacerbate renal dysfunction in CTRP1-deficient animals. To test this, we fed wild-type and Ctrp1-KO mice a high-fat diet for 8 mo or longer. Contrary to our expectation, no differences were observed in blood pressure, heart function, or vascular stiffness between genotypes. Loss of CTRP1, however, resulted in an approximately twofold renal enlargement (relative to body weight), ∼60% increase in urinary total protein content, and elevated pH, and changes in renal gene expression affecting metabolism, signaling, transcription, cell adhesion, solute and metabolite transport, and inflammation. Assessment of glomerular integrity, the extent of podocyte foot process effacement, as well as renal response to water restriction and salt loading did not reveal significant differences between genotypes. Interestingly, blood platelet, white blood cell, neutrophil, lymphocyte, and eosinophil counts were significantly elevated, whereas mean corpuscular volume and hemoglobin were reduced in Ctrp1-KO mice. Cytokine profiling revealed increased circulating levels of CCL17 and TIMP-1 in KO mice. Compared with our previous study, current data suggest that chronic high-fat feeding affects renal phenotypes differently than similarly aged mice fed a control low-fat diet, highlighting a diet-dependent contribution of CTRP1 deficiency to age-related changes in renal structure and function.

Diet-induced obesity and hepatic gene expression alterations in C57BL/6J and ICAM-1-deficient mice

2002 ◽  
Vol 282 (3) ◽  
pp. E703-E713 ◽  
Author(s):  
Francine M. Gregoire ◽  
Qin Zhang ◽  
Steven J. Smith ◽  
Carmen Tong ◽  
David Ross ◽  
...  
Keyword(s):  
Gene Expression ◽  
High Fat Diet ◽  
Regulatory Element ◽  
Intercellular Adhesion Molecule ◽  
High Fat ◽  
Intercellular Adhesion Molecule 1 ◽  
Affymetrix Genechips ◽  
Element Binding Protein ◽  
Liver Gene ◽  
Deficient Mice

The effects of high-fat feeding on the development of obesity were evaluated in intercellular adhesion molecule-1 (ICAM-1) knockout and C57BL/6J (B6) male mice fed a high-fat diet for ≤50 days. Serum and tissues were collected at baseline and after 1, 11, and 50 days on the diet. After 11 days on the diet, ICAM-1-deficient, but not B6, mice developed fatty livers and showed a significant increase in inguinal fat pad weight. At day 50, ICAM-1-deficient mice weighed less, and their adiposity index and circulating leptin levels were significantly lower than those of B6 controls. To better understand the early differential response to the diet, liver gene expression was analyzed at three time points by use of Affymetrix GeneChips. In both strains, a similar pattern of gene expression was detected in response to the high-fat diet. However, sterol regulatory element-binding protein-1, apolipoprotein A4, and adipsin mRNAs were significantly induced in ICAM-1-deficient livers, suggesting that these genes and their associated pathways may be involved in the acute diet response observed in the knockout mice.

141: Gene Expression in Response to High-Fat Feeding in Human Prostate Cancer Xenograft Model

2007 ◽  
Vol 177 (4S) ◽  
pp. 48-48
Author(s):  
Shintaro Narita ◽  
Norihiko Tsuchiya ◽  
Mitsuru Saito ◽  
Takamitsu Inoue ◽  
Teruaki Kumazawa ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Xenograft Model ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
High Fat ◽  
Fat Feeding

scholarly journals Effects of High-Fat Feeding on Skeletal Muscle Gene Expression in Diabetic Goto-Kakizaki Rats

2017 ◽  
Vol 11 ◽  
pp. 117762501771000 ◽  
Author(s):  
Jing Nie ◽  
Debra C DuBois ◽  
Bai Xue ◽  
William J Jusko ◽  
Richard R Almon
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
High Fat ◽  
Muscle Gene Expression ◽  
Muscle Gene ◽  
Fat Feeding

scholarly journals Jersey calf performance in response to high-protein, high-fat liquid feeds with varied fatty acid profiles: Blood metabolites and liver gene expression

2013 ◽  
Vol 96 (6) ◽  
pp. 3845-3856 ◽  
Author(s):  
V.A. Swank ◽  
W.S.Bowen Yoho ◽  
K.M. O’Diam ◽  
M.L. Eastridge ◽  
A.J. Niehaus ◽  
...  
Keyword(s):  
Gene Expression ◽  
Fatty Acid ◽  
High Protein ◽  
Blood Metabolites ◽  
Fatty Acid Profiles ◽  
High Fat ◽  
Calf Performance ◽  
Liver Gene

CTRP6 rapidly responds to acute nutritional changes, regulating adipose tissue expansion and inflammation in mice

2021 ◽  
Author(s):  
Rotem Lahav ◽  
Yulia Haim ◽  
Nikhil Suresh Bhandarkar ◽  
Liron Levin ◽  
Vered Chalifa-Caspi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Tissue Expansion ◽  
Whole Body ◽  
Metabolic Dysfunction ◽  
Wild Type ◽  
High Fat ◽  
Tnf Α ◽  
Fat Feeding ◽  
Nutritional Changes

In chronic obesity, activated adipose tissue pro-inflammatory cascades are tightly linked to metabolic dysfunction. Yet, close temporal analyses of the responses to obesogenic environment such as high-fat feeding (HFF) in susceptible mouse strains question the causal relationship between inflammation and metabolic dysfunction, and/or raises the possibility that certain inflammatory cascades play adaptive/homeostatic, rather than pathogenic roles. Here we hypothesized that CTRP6, a C1QTNF family member, may constitute an early responder to acute nutritional changes in adipose tissue, with potential physiological roles. Both 3 days high-fat feeding (3dHFF) and acute obesity reversal (2 weeks switch to low-fat diet after 8w-HFF) already induced marked changes in whole-body fuel utilization. While adipose tissue expression of classical pro-inflammatory cytokines (Tnf-α, Ccl2, Il1b) exhibited no, or only minor, change, C1qtnf6 uniquely increased, and decreased, in response to 3dHFF and acute obesity reversal, respectively. CTRP6 knockout (KO) mouse embryonic fibroblasts (MEF) exhibited increased adipogenic gene expression (Pparg, Fabp4, Adipoq) and markedly reduced inflammatory genes (Tnf-α, Ccl2, Il6) compared to wild-type MEF, and recombinant CTRP6 induced the opposite gene expression signature, as assessed by RNA-sequencing. Consistently, 3dHFF of CTRP6-KO mice induced a greater whole-body and adipose tissue weight gain compared to wild-type littermates. Collectively, we propose CTRP6 as a gene that rapidly responds to acute changes in caloric intake, acting in acute over-nutrition to induce a "physiological inflammatory response" that limits adipose tissue expansion.

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