scholarly journals “Old” and emerging Therapies of Human Tremor

2010 ◽  
Vol 2 ◽  
pp. CMT.S2999 ◽  
Author(s):  
G. Grimaldi ◽  
M. Manto
Keyword(s):  
Deep Brain Stimulation ◽  
Movement Disorder ◽  
Essential Tremor ◽  
Brain Stimulation ◽  
Daily Practice ◽  
Pharmacological Therapy ◽  
Review Article ◽  
Pharmacological Agents ◽  
Emerging Therapies ◽  
Deep Brain

Tremor is the most common movement disorder encountered during daily practice. Most forms of tremor are currently managed with drugs. However, the response of tremor to pharmacotherapy is variable and a combination of agents is often required. Surgery is considered when the response is not sufficient. In particular deep brain stimulation (DBS) is now playing a key-role, especially for refractory Parkinson's disease. DBS is also a well established therapy for essential tremor resistant to pharmacological therapy. New therapies are emerging, not only in the field of pharmacological agents, but also in the domain of bioengineering. They are presented in this review article.

scholarly journals Modeling mechanisms of tremor reduction for essential tremor using symmetric biphasic DBS

2019 ◽  
Author(s):  
Shane Lee ◽  
Wael F Asaad ◽  
Stephanie R Jones
Keyword(s):  
Deep Brain Stimulation ◽  
Side Effects ◽  
Movement Disorder ◽  
Essential Tremor ◽  
Brain Stimulation ◽  
Future Studies ◽  
Tremor Frequency ◽  
Ventral Intermediate Nucleus ◽  
Different Shapes ◽  
Deep Brain

AbstractEssential tremor (ET) is the most common movement disorder, in which the primary symptom is a prominent, involuntary 4–10 Hz movement. For severe, medication refractory cases, deep brain stimulation (DBS) targeting the ventral intermediate nucleus of the thalamus (VIM) can be an effective treatment for cessation of tremor and is thought to work in part by disrupting tremor frequency oscillations (TFOs) in VIM. However, DBS is not universally effective and may be further disrupting cerebellar-mediated activity in the VIM. Here, we applied biophysically detailed computational modeling to investigate whether the efficacy of DBS is affected by the mechanism of generation of TFOs or by the pattern of stimulation. We simulated the effects of DBS using standard, asymmetric pulses as well as biphasic, symmetric pulses to understand biophysical mechanisms of how DBS disrupts TFOs generated either extrinsically or intrinsically. The model results suggested that the efficacy of DBS in the VIM is affected by the mechanism of generation of TFOs. Symmetric biphasic DBS reduced TFOs more than standard DBS in both networks, and these effects were stronger in the intrinsic network. For intrinsic tremor frequency activity, symmetric biphasic DBS was more effective at reducing TFOs. Simulated non-tremor signals were also transmitted during symmetric biphasic DBS, suggesting that this type of DBS may help to reduce side effects caused by disruption of the cerebellothalamocortical pathway. Biophysical details in the model provided a mechanistic interpretation of the cellular and network dynamics contributing to these effects that can be empirically tested in future studies.Significance StatementEssential tremor (ET) is a common movement disorder, whose primary symptom is an involuntary rhythmic movement of the limbs or head. An area of the human tha-lamus demonstrates electrical activity that oscillates at the frequencies of tremor, and deep brain stimulation (DBS) in this area can reduce tremor. It is not fully understood how DBS affects tremor frequency activity in the thalamus, and studying different patterns of DBS stimulation may help to clarify these mechanisms. We created a computational model of different shapes of DBS and studied how they reduce different hypothesized generators of tremor frequency activity. A greater understanding of how DBS affects the thalamus may lead to improved treatments to reduce tremor and alleviate side effects in patients with ET.

scholarly journals Impact of an Interdisciplinary Deep Brain Stimulation Screening Model on Post-Surgical Complications in Essential Tremor Patients

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0145623 ◽  
Author(s):  
Masa-aki Higuchi ◽  
Dan D. Topiol ◽  
Bilal Ahmed ◽  
Hokuto Morita ◽  
Samuel Carbunaru ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Essential Tremor ◽  
Brain Stimulation ◽  
Surgical Complications ◽  
Screening Model ◽  
Deep Brain

scholarly journals Long-Term Effects of Deep Brain Stimulation for Essential Tremor with Subjective and Objective Quantification via Mailed-In Questionnaires

2012 ◽  
Vol 90 (6) ◽  
pp. 394-400 ◽  
Author(s):  
Tatiana H. de Oliveira ◽  
Matthew R. Ginsberg ◽  
Scott Cooper ◽  
Amy Nowacki ◽  
Ali Rezai ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Essential Tremor ◽  
Brain Stimulation ◽  
Long Term Effects ◽  
Objective Quantification ◽  
Deep Brain

scholarly journals Improved spatial targeting with directionally segmented deep brain stimulation leads for treating essential tremor

2012 ◽  
Vol 9 (4) ◽  
pp. 046005 ◽  
Author(s):  
Maureen Keane ◽  
Steve Deyo ◽  
Aviva Abosch ◽  
Jawad A Bajwa ◽  
Matthew D Johnson
Keyword(s):  
Deep Brain Stimulation ◽  
Essential Tremor ◽  
Brain Stimulation ◽  
Spatial Targeting ◽  
Deep Brain

Deep Brain Stimulation in an Additional Patient With ADCY5-Related Movement Disorder

2016 ◽  
Vol 32 (4) ◽  
pp. 438-439 ◽  
Author(s):  
Inge A. Meijer ◽  
Joan Miravite ◽  
Brian H. Kopell ◽  
Naomi Lubarr
Keyword(s):  
Deep Brain Stimulation ◽  
Movement Disorder ◽  
Brain Stimulation ◽  
Additional Patient ◽  
Deep Brain

scholarly journals Exchange of a Stimulator with a New Conductive Device to Control Tremor Capability in an Essential Tremor Patient Treated by Thalamic Deep Brain Stimulation

2020 ◽  
Vol 79 (1) ◽  
pp. 15-18
Author(s):  
Hiroyuki Aoki ◽  
Hideki Oshima ◽  
Mitsuru Watanabe ◽  
Kazutaka Kobayashi ◽  
Chikashi Fukaya ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Essential Tremor ◽  
Brain Stimulation ◽  
Deep Brain
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