scholarly journals Long-Term Effects of Deep Brain Stimulation for Essential Tremor with Subjective and Objective Quantification via Mailed-In Questionnaires

2012 ◽  
Vol 90 (6) ◽  
pp. 394-400 ◽  
Author(s):  
Tatiana H. de Oliveira ◽  
Matthew R. Ginsberg ◽  
Scott Cooper ◽  
Amy Nowacki ◽  
Ali Rezai ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Essential Tremor ◽  
Brain Stimulation ◽  
Long Term Effects ◽  
Objective Quantification ◽  
Deep Brain

scholarly journals Longitudinal follow-up with VIM thalamic deep brain stimulation for dystonic or essential tremor

Neurology ◽  
2020 ◽  
Vol 94 (10) ◽  
pp. e1073-e1084 ◽  
Author(s):  
Takashi Tsuboi ◽  
Zakia Jabarkheel ◽  
Pamela R. Zeilman ◽  
Matthew J. Barabas ◽  
Kelly D. Foote ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Essential Tremor ◽  
Brain Stimulation ◽  
Rating Scale ◽  
Statistical Significance ◽  
Ventral Intermediate Nucleus ◽  
Deep Brain

ObjectiveTo assess longitudinal tremor outcomes with ventral intermediate nucleus deep brain stimulation (VIM DBS) in patients with dystonic tremor (DT) and to compare with DBS outcomes in essential tremor (ET).MethodsWe retrospectively investigated VIM DBS outcomes for 163 patients followed at our center diagnosed with either DT or ET. The Fahn-Tolosa-Marin tremor rating scale (TRS) was used to assess change in tremor and activities of daily living (ADL) at 6 months, 1 year, 2–3 years, 4–5 years, and ≥6 years after surgery.ResultsTwenty-six patients with DT and 97 patients with ET were analyzed. Compared to preoperative baseline, there were significant improvements in TRS motor up to 4–5 years (52.2%; p = 0.032) but this did not reach statistical significance at ≥6 years (46.0%, p = 0.063) in DT, which was comparable to the outcomes in ET. While the improvements in the upper extremity tremor, head tremor, and axial tremor were also comparable between DT and ET throughout the follow-up, the ADL improvements in DT were lost at 2–3 years follow-up.ConclusionOverall, tremor control with VIM DBS in DT and ET was comparable and remained sustained at long term likely related to intervention at the final common node in the pathologic tremor network. However, the long-term ADL improvements in DT were not sustained, possibly due to inadequate control of concomitant dystonia symptoms. These findings from a large cohort of DT indicate that VIM targeting is reasonable if the tremor is considerably more disabling than the dystonic features.Classification of evidenceThis study provides Class IV evidence that VIM DBS improves tremor in patients with DT or ET.

Long-term effects of anterior pallidal deep brain stimulation for tourette's syndrome

2019 ◽  
Vol 34 (4) ◽  
pp. 586-588 ◽  
Author(s):  
Marie-Laure Welter ◽  
Jean-Luc Houeto ◽  
Yulia Worbe ◽  
Mamadou Hassimiou Diallo ◽  
Andreas Hartmann ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Long Term Effects ◽  
Pallidal Deep Brain Stimulation ◽  
Deep Brain

Long-term efficacy of deep brain stimulation for essential tremor

Neurology ◽  
2019 ◽  
Vol 92 (12) ◽  
pp. e1378-e1386 ◽  
Author(s):  
Steffen Paschen ◽  
Julia Forstenpointner ◽  
Jos Becktepe ◽  
Sebastian Heinzel ◽  
Helge Hellriegel ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Essential Tremor ◽  
Brain Stimulation ◽  
Rating Scale ◽  
Rebound Effect ◽  
Short Term ◽  
Term Efficacy ◽  
Secondary Outcomes ◽  
Deep Brain

ObjectiveDeep brain stimulation (DBS) of the ventral intermediate thalamic nucleus (Vim) is established for medically refractory severe essential tremor (ET), but long-term efficacy is controversial.MethodsTwenty patients with ET with DBS had standardized video-documented examinations at baseline, in the stimulation-on condition at short term (13.1 ± 1.9 months since surgery, mean ± SEM), and in the stimulator switched on and off (stim-ON/OFF) at long term; all assessments were done between 32 and 120 months (71.9 ± 6.9 months) after implantation. The primary outcome was the Tremor Rating Scale (TRS) blindly assessed by 2 trained movement disorder neurologists. Secondary outcomes were TRS subscores A, B, and C; Archimedes spiral score; and activities of daily living score. At long-term follow-up, tremor was additionally recorded with accelerometry. The rebound effect after switching the stimulator off was assessed for 1 hour in a subgroup.ResultsTremor severity worsened considerably over time in both in the nonstimulated and stimulated conditions. Vim-DBS improved the TRS in the short term and long term significantly. The spiral score and functional measures showed similar improvements. All changes were highly significant. However, the stimulation effect was negatively correlated with time since surgery (ρ = −0.78, p < 0.001). This was also true for the secondary outcomes. Only one-third of the patients had a rebound effect terminated 60 minutes after the stimulator was switched off. Long-term worsening of the TRS was more profound during stim-ON than in the stim-OFF condition, indicating habituation to stimulation.ConclusionVim-DBS loses efficacy over the long term. Efforts are needed to improve the long-term efficacy of Vim-DBS.Classification of evidenceThis study provides Class IV evidence that for patients with medically refractory severe ET, the efficacy of Vim-DBS severely decreases over 10 years.

scholarly journals Long-term Thalamic Deep Brain Stimulation for Essential Tremor: Clinical Outcome and Stimulation Parameters

2016 ◽  
Vol 3 (6) ◽  
pp. 567-572 ◽  
Author(s):  
Pedro M. Rodríguez Cruz ◽  
Antonio Vargas ◽  
Carlos Fernández-Carballal ◽  
Jose Garbizu ◽  
Beatriz De La Casa-Fages ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Clinical Outcome ◽  
Essential Tremor ◽  
Brain Stimulation ◽  
Stimulation Parameters ◽  
Deep Brain

Long-term safety and efficacy of unilateral deep brain stimulation of the thalamus in essential tremor

2001 ◽  
Vol 16 (3) ◽  
pp. 464-468 ◽  
Author(s):  
William C. Koller ◽  
Kelly E. Lyons ◽  
Steven B. Wilkinson ◽  
Alexander I. Troster ◽  
Rajesh Pahwa
Keyword(s):  
Deep Brain Stimulation ◽  
Essential Tremor ◽  
Brain Stimulation ◽  
Safety And Efficacy ◽  
Deep Brain ◽  
Stimulation Of

Long-term effects of pallidal deep brain stimulation in tardive dystonia

Neurology ◽  
2009 ◽  
Vol 73 (1) ◽  
pp. 53-58 ◽  
Author(s):  
D. Gruber ◽  
T. Trottenberg ◽  
A. Kivi ◽  
T. Schoenecker ◽  
U. A. Kopp ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Long Term Effects ◽  
Tardive Dystonia ◽  
Pallidal Deep Brain Stimulation ◽  
Deep Brain

Beyond verbal fluency: Investigating the long-term effects of bilateral subthalamic (STN) deep brain stimulation (DBS) on language function in two cases

Neurocase ◽  
2005 ◽  
Vol 11 (2) ◽  
pp. 93-102 ◽  
Author(s):  
Brooke-mai Whelan ◽  
Bruce E. Murdoch ◽  
Deborah G. Theodoros ◽  
Peter Silburn ◽  
Bruce Hall
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Verbal Fluency ◽  
Language Function ◽  
Long Term Effects ◽  
Deep Brain
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