Genetic and Epigenetic Modifications in Systemic Lupus Erythematosus: Challenges to Homeostatic Immune Responses

2016 ◽  
Vol 8 ◽  
pp. 1-6
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Immune Responses ◽  
Lupus Erythematosus ◽  
Epigenetic Modifications ◽  
Systemic Lupus

Comprehensive analysis of epigenetic modifications and immune-cell infiltration in tissues from patients with systemic lupus erythematosus

Epigenomics ◽  
2021 ◽  
Author(s):  
Zhenghao He ◽  
Shihang Zhou ◽  
Ming Yang ◽  
Zhidan Zhao ◽  
Yang Mei ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Dna Methylation ◽  
Lupus Erythematosus ◽  
Immune Cell ◽  
Epigenetic Modifications ◽  
Cell Infiltration ◽  
Immune Cell Infiltration ◽  
Methylation Analysis ◽  
Systemic Lupus ◽  
Dna Methylation Analysis

Aim: To explore potential abnormal epigenetic modifications and immune-cell infiltration in tissues from systemic lupus erythematosus (SLE) patients. Materials & methods: To utilize bioinformatics analysis and ‘wet lab' methods to identify and verify differentially expressed genes in multiple targeted organs in SLE. Results: Seven key genes, IFI44, IFI44L, IFIT1, IFIT3, PLSCR1, RSAD2 and OAS2, which are regulated by epigenetics and may be involved in the pathogenesis of SLE, are identified by combined long noncoding RNA–miRNA–mRNA network analysis and DNA methylation analysis. The results of quantitative reverse transcription PCR, immunohistochemistry and DNA methylation analysis confirmed the potential of these genes as biomarkers. Conclusion: This study reveals the potential mechanisms in SLE from epigenetic modifications and immune-cell infiltration, providing diagnostic biomarkers and therapeutic targets for SLE.

scholarly journals Assessing the expression of immunosuppressive cytokines in the newly diagnosed systemic lupus Erythematosus patients: a focus on B cells

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Mitra Abbasifard ◽  
Zahra Kamiab ◽  
Mohammad Hasani ◽  
Amir Rahnama ◽  
Pooya Saeed-Askari ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
B Cells ◽  
Immune Responses ◽  
Lupus Erythematosus ◽  
Healthy Subjects ◽  
Serum Levels ◽  
Newly Diagnosed ◽  
Systemic Lupus ◽  
Moderate Disease ◽  
Immunosuppressive Cytokines

Abstract Background The immunosuppressive effects of regulatory B-cells (Bregs) and their immunosuppressive cytokines on immune responses in autoimmune disorders, mainly systemic lupus erythematosus (SLE), have been recently established. Therefore, the purpose of this article has been the exploration of the expressions of cytokines produced by B cells in newly diagnosed SLE patients. Results The findings demonstrated that the gene expression of IL-10, TGF-β, IL-35, PD-L1, and FasL was significantly up-regulated in SLE patients compared to healthy subjects (P < 0.05). Additionally, the results revealed that serum levels of IL-10, TGF-β, IL-35, PD-L1 were remarkably increased in patients with SLE compared to healthy subjects (P < 0.0001). However, serum levels of IL-10 and TGF-β decreased significantly with increasing SLEDAI score in studied patients (P < 0.05). Conclusion It was concluded that the release of anti-inflammatory cytokines, particularly IL-10 and TGF-β, might inhibit immune responses and autoreactive immune cells in a compensatory manner in SLE patients with mild to moderate disease activity.

scholarly journals Studies of cell-mediated immune responses to influenza vaccination in systemic lupus erythematosus

2009 ◽  
Vol 60 (8) ◽  
pp. 2438-2447 ◽  
Author(s):  
Albert Holvast ◽  
Sander van Assen ◽  
Aalzen de Haan ◽  
Anke Huckriede ◽  
Cornelis A. Benne ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Immune Responses ◽  
Influenza Vaccination ◽  
Lupus Erythematosus ◽  
Systemic Lupus

scholarly journals Genetics of systemic lupus erythematosus: immune responses and end organ resistance to damage

2014 ◽  
Vol 31 ◽  
pp. 87-96 ◽  
Author(s):  
Chao Dai ◽  
Yun Deng ◽  
Aaron Quinlan ◽  
Felicia Gaskin ◽  
Betty P Tsao ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Immune Responses ◽  
Lupus Erythematosus ◽  
Systemic Lupus

scholarly journals Immune responses to an early lytic cytomegalovirus antigen in systemic lupus erythematosus patients: T-cell responses, cytokine secretions and antibody status

PLoS ONE ◽  
2018 ◽  
Vol 13 (3) ◽  
pp. e0193244 ◽  
Author(s):  
Anette Holck Draborg ◽  
Niclas Stefan Rasmussen ◽  
Janni Lisander Larsen ◽  
Charlotte Sværke Jørgensen ◽  
Noreen Sandhu ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
T Cell ◽  
Immune Responses ◽  
Lupus Erythematosus ◽  
T Cell Responses ◽  
Systemic Lupus ◽  
Cell Responses
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