Cellular Immune Responses in Systemic Lupus Erythematosus (Part 2 of 3)

1984 ◽  
pp. 116-138
Author(s):  
George C. Tsokos ◽  
James E. Balow
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Immune Responses ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Cellular Immune Responses ◽  
Cellular Immune

scholarly journals Assessing the expression of immunosuppressive cytokines in the newly diagnosed systemic lupus Erythematosus patients: a focus on B cells

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Mitra Abbasifard ◽  
Zahra Kamiab ◽  
Mohammad Hasani ◽  
Amir Rahnama ◽  
Pooya Saeed-Askari ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
B Cells ◽  
Immune Responses ◽  
Lupus Erythematosus ◽  
Healthy Subjects ◽  
Serum Levels ◽  
Newly Diagnosed ◽  
Systemic Lupus ◽  
Moderate Disease ◽  
Immunosuppressive Cytokines

Abstract Background The immunosuppressive effects of regulatory B-cells (Bregs) and their immunosuppressive cytokines on immune responses in autoimmune disorders, mainly systemic lupus erythematosus (SLE), have been recently established. Therefore, the purpose of this article has been the exploration of the expressions of cytokines produced by B cells in newly diagnosed SLE patients. Results The findings demonstrated that the gene expression of IL-10, TGF-β, IL-35, PD-L1, and FasL was significantly up-regulated in SLE patients compared to healthy subjects (P < 0.05). Additionally, the results revealed that serum levels of IL-10, TGF-β, IL-35, PD-L1 were remarkably increased in patients with SLE compared to healthy subjects (P < 0.0001). However, serum levels of IL-10 and TGF-β decreased significantly with increasing SLEDAI score in studied patients (P < 0.05). Conclusion It was concluded that the release of anti-inflammatory cytokines, particularly IL-10 and TGF-β, might inhibit immune responses and autoreactive immune cells in a compensatory manner in SLE patients with mild to moderate disease activity.

Sign in / Sign up

Export Citation Format

Share Document