scholarly journals Resectable Cholangiocarcinoma: Reviewing the Role of Adjuvant Strategies

2016 ◽  
Vol 10 ◽  
pp. CMO.S32821 ◽  
Author(s):  
E. Una Cidon

Cholangiocarcinoma is a very heterogeneous and rare group of neoplasms originating from the perihilar, intra-, or extrahepatic bile duct epithelium. It represents only 3% of gastrointestinal cancers, although their incidence is increasing as its mortality increases. Surgical resection is the only potentially curative option, but unfortunately the resectability rate is low. Overall, these malignancies have got a very poor prognosis with a five-year survival rate of 5–10%. Although the five-year survival rate increases to 25–30% in the cases amenable to surgery, only 10–40% of patients present with resectable disease. Therefore, it is necessary to optimize the benefit of adjuvant strategies after surgery to increase the rate of curability. This study reviewed the role of adjuvant chemotherapy in resectable bile duct cancers.

2015 ◽  
Vol 2015 ◽  
pp. 1-14 ◽  
Author(s):  
Kelly J. Lafaro ◽  
David Cosgrove ◽  
Jean-Francois H. Geschwind ◽  
Ihab Kamel ◽  
Joseph M. Herman ◽  
...  

Cholangiocarcinoma is a highly fatal primary cancer of the bile ducts which arises from malignant transformation of bile duct epithelium. While being an uncommon malignancy with an annual incidence in the United States of 5000 new cases, the incidence has been increasing over the past 30 years and comprises 3% of all gastrointestinal cancers. Cholangiocarcinoma can be classified into intrahepatic (ICC) and extrahepatic (including hilar and distal bile duct) according to its anatomic location within the biliary tree with respect to the liver. This paper reviews the management of ICC, focusing on the epidemiology, risk factors, diagnosis, and surgical and nonsurgical management.


Radiology ◽  
1996 ◽  
Vol 199 (3) ◽  
pp. 861-866 ◽  
Author(s):  
P Montemaggi ◽  
A G Morganti ◽  
R R Dobelbower ◽  
G Brizi ◽  
D Smaniotto ◽  
...  

1992 ◽  
Vol 27 (10) ◽  
pp. 845-851 ◽  
Author(s):  
T. Ohta ◽  
T. Nagakawa ◽  
Y. Tsukioka ◽  
H. Sanada ◽  
I. Miyazaki ◽  
...  

Hepatology ◽  
1998 ◽  
Vol 28 (3) ◽  
pp. 620-623 ◽  
Author(s):  
Koichi Tsuneyama ◽  
Mitsue Yasoshima ◽  
Kenichi Harada ◽  
Katsushi Hiramatsu ◽  
M. Eric Gershwin ◽  
...  

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