scholarly journals Multidisciplinary Care of Patients with Intrahepatic Cholangiocarcinoma: Updates in Management

2015 ◽  
Vol 2015 ◽  
pp. 1-14 ◽  
Author(s):  
Kelly J. Lafaro ◽  
David Cosgrove ◽  
Jean-Francois H. Geschwind ◽  
Ihab Kamel ◽  
Joseph M. Herman ◽  
...  
Keyword(s):  
Bile Duct ◽  
Bile Ducts ◽  
Multidisciplinary Care ◽  
Biliary Tree ◽  
The United States ◽  
Gastrointestinal Cancers ◽  
The Past ◽  
Nonsurgical Management ◽  
Duct Epithelium ◽  
Bile Duct Epithelium

Cholangiocarcinoma is a highly fatal primary cancer of the bile ducts which arises from malignant transformation of bile duct epithelium. While being an uncommon malignancy with an annual incidence in the United States of 5000 new cases, the incidence has been increasing over the past 30 years and comprises 3% of all gastrointestinal cancers. Cholangiocarcinoma can be classified into intrahepatic (ICC) and extrahepatic (including hilar and distal bile duct) according to its anatomic location within the biliary tree with respect to the liver. This paper reviews the management of ICC, focusing on the epidemiology, risk factors, diagnosis, and surgical and nonsurgical management.

Observations on oocyst development of Eimeria stiedai in rabbits

2014 ◽  
Vol 59 (3) ◽  
Author(s):  
Stanley Ball ◽  
Micheal Pittilo ◽  
Keith Snow
Keyword(s):  
Bile Duct ◽  
Outer Layer ◽  
Bile Ducts ◽  
Cell Damage ◽  
Parasite Development ◽  
Oocyst Wall ◽  
Duct Epithelium ◽  
Bile Duct Epithelium ◽  
Eimeria Stiedai ◽  
Membrane Cell

AbstractThe formation of the oocyst wall was examined in Eimeria stiedai in the bile duct epithelium of the rabbit and was found to follow the general eimerian pattern. However from the beginning of the formation of the outer layer of the oocyst wall the parasite was surrounded by a rarely reported veil membrane. Cell damage of the bile ducts at the gamogony stage of parasite development is depicted.

scholarly journals Intrabiliary Hepatic Metastasis of Colorectal Carcinoma Mimicking Primary Cholangiocarcinoma: A Case Report and Review of the Literature

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Yimin Dong ◽  
Hitendra Patel ◽  
Charmi Patel
Keyword(s):  
Bile Duct ◽  
Colorectal Carcinoma ◽  
Bile Ducts ◽  
Past History ◽  
Correct Diagnosis ◽  
Liver Parenchyma ◽  
Duct Epithelium ◽  
Metastatic Growth ◽  
Bile Duct Epithelium ◽  
Intrabiliary Growth

Intrabiliary metastasis from colorectal carcinoma (CRC) growing within or invading bile ducts is not a very common pattern. However, accurate diagnosis of metastatic lesions is very important for selection of adjuvant therapy and prognosis. We report a case of 71-year-old male who developed painless jaundice due to hepatobiliary obstruction. MRI demonstrated 1.4 cm intraductal mass at hepatic hilum with severe intrahepatic ductal dilation, consistent with cholangiocarcinoma. ERCP (endoscopic retrograde cholangiopancreatography) showed intraductal segmental biliary stricture. Biopsy from the lesion showed adenocarcinoma favoring primary cholangiocarcinoma due to the papillary morphology and location of the mass. His past history was significant for rectosigmoid carcinoma (pT1N0) ten years ago and liver resection for metastatic CRC four years ago. He subsequently underwent central hepatectomy with resection of common bile duct. Grossly, there was a 1.2 cm intraductal mass at the bifurcation of bile ducts with multiple nodules in liver parenchyma. Microscopic examination revealed intraductal carcinoma with papillary architecture colonizing bile duct epithelium with resultant dilation and tortuosity. Occasional liver parenchymal nodules show classical metastatic pattern resembling CRC. Because of two distinct morphologic patterns and patient’s past history, immunostains were performed. CK7 stained uninvolved bile duct epithelium with no staining in intrabiliary metastatic growth. CK20 and CDX2 were positive, thus confirming intrabiliary growth as metastatic growth from CRC. In summary, findings from our case indicate that intrabiliary growth of metastatic CRC can easily be overlooked with major duct involvement. Pathologic evaluation with use of immunohistochemical stains is very important to achieve correct diagnosis.

scholarly journals Resectable Cholangiocarcinoma: Reviewing the Role of Adjuvant Strategies

2016 ◽  
Vol 10 ◽  
pp. CMO.S32821 ◽  
Author(s):  
E. Una Cidon
Keyword(s):  
Survival Rate ◽  
Bile Duct ◽  
Poor Prognosis ◽  
Extrahepatic Bile Duct ◽  
Gastrointestinal Cancers ◽  
Resectable Disease ◽  
Duct Epithelium ◽  
Bile Duct Epithelium ◽  
Rare Group

Cholangiocarcinoma is a very heterogeneous and rare group of neoplasms originating from the perihilar, intra-, or extrahepatic bile duct epithelium. It represents only 3% of gastrointestinal cancers, although their incidence is increasing as its mortality increases. Surgical resection is the only potentially curative option, but unfortunately the resectability rate is low. Overall, these malignancies have got a very poor prognosis with a five-year survival rate of 5–10%. Although the five-year survival rate increases to 25–30% in the cases amenable to surgery, only 10–40% of patients present with resectable disease. Therefore, it is necessary to optimize the benefit of adjuvant strategies after surgery to increase the rate of curability. This study reviewed the role of adjuvant chemotherapy in resectable bile duct cancers.

Primary Epidermoid Cyst of Biliary Duct Presenting as Choledochal Cyst

2017 ◽  
Vol 25 (7) ◽  
pp. 619-622 ◽  
Author(s):  
Dong Hyang Kwon ◽  
Lynt B. Johnson ◽  
Metin Ozdemirli
Keyword(s):  
Bile Duct ◽  
Choledochal Cyst ◽  
Squamous Metaplasia ◽  
Biliary Tree ◽  
Biliary Duct ◽  
Duct Epithelium ◽  
Duct Systems ◽  
Risk Of Malignancy ◽  
Stratified Squamous Epithelium ◽  
Bile Duct Epithelium

Choledochal cyst is a cystic dilation of the biliary tree that can increase the risk of malignancy in bile ducts and the gallbladder. These are usually lined by bile duct epithelium, which may undergo intestinal and squamous metaplasia. This is the first report of clinically diagnosed type II choledochal cyst that is entirely lined by metaplastic stratified squamous epithelium, unlike most other cysts, which are histologically lined by bile duct epithelium. This observation can potentially explain the underlying pathogenic mechanism of rare reports of squamous cell carcinomas arising in bile duct systems.

scholarly journals Automatic Intrahepatic Biliary Segmentation Based Image Processing Techniques using Magnetic Resonance Images

2020 ◽  
Author(s):  
Mohammad Atallah AL-Oudat ◽  
Mohammad AL Oudat ◽  
Hazem Migdady ◽  
Tariq AL Munaizel ◽  
Mohammad Awni Mahmoud ◽  
...  
Keyword(s):  
Bile Duct ◽  
Magnetic Resonance ◽  
Bile Ducts ◽  
Medical Condition ◽  
Biliary Tree ◽  
Extraction Process ◽  
Magnetic Resonance Images ◽  
Papilla Of Vater ◽  
Feed Forward Neural Network ◽  
Important Indicator

Abstract A set of tubes known as bile ducts connects the liver to an organ below it directly that is called Gallbladder. The dilation of a bile duct is an important indicator regarding any serious issue in the human body. Number of reasons may cause bile duct dilation, such as: stones, tumors which commonly occur due to pancreas or papilla of vater. In this paper, the main contributions are: 1) a novel framework that consists of three phases to be applied on a set of Magnetic Resonance Imaging (MRI) images 2) an extracted set of features with their accurate values that express the condition of the biliary trees from the MRI images. Such dataset can be used in several applications to determine whether a bile duct is dilated or not. The dataset is organized as the following: half of the MRI images are for normal bile ducts, while the other half is for dilated bile ducts. To extract the useful features to diagnose the medical condition of the bile ducts from the MRI images, we implemented and applied the proposed framework that is started by using the enhanced active contour technique without edges in combination with Denoising Convolutional Neural Networks (DnCNN) to perform the segmentation and features extraction process. After that, the output of the segmentation process is the segmented biliary tree that will be used later to extract the needful features to make a diagnostic decision whether there is a dilation or not by comparing the features values of the normal versus the dilated bile ducts. We applied the feed forward neural network with backpropagation training algorithm for classification purposes. According to the experiments, the overall accuracy of the proposed framework was 90.00%. Such approach improves and increases the accuracy of the physicians’ diagnostic decisions which is considered as of significant importance for treatment and cure.

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